PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000125184
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family HD-ZIP
Protein Properties Length: 679aa    MW: 75532.5 Da    PI: 5.8443
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000125184genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox60.33.1e-192276256
                   T--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
       Homeobox  2 rkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                   +k +++t+eq+++Lee F+ + +p+ ++r++L ++lgL+ +q+k+WFqN+R++ k
  MDP0000125184 22 KKYHRHTNEQIQRLEEXFKHCAHPDDSQRQQLGRELGLEPKQIKFWFQNKRTQTK 76
                   78999**********************************************9987 PP
2START139.92.6e-441914132206
                    HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEEEEE CS
          START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv.....dsgealrasgvvdmvlallveellddkeqWdetla....kaetlev 84 
                    +a +a++elvk+ + +ep+Wvks       +n+  + ++f++++       ++e +++sgvv+  +a+lv  +ld++ +W e ++    ka+t+ev
  MDP0000125184 191 IAASALEELVKLFQIDEPLWVKSTaygrYFLNRGNYDKIFPRTNQfktssARIESSKDSGVVTISAATLVDMFLDSN-KWEELFPtivtKAKTIEV 285
                    678899******************999988899999999988877899999**************************.******99999******* PP

                    ECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE-- CS
          START  85 issg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwvehvdlk 173
                    ++sg      g l lm+ ++  lsplv  Rdf+f+Ry++q + g+wv vdvS   +++   ss+  R+ +lpSg+li+++ ng skvtw+ehv+++
  MDP0000125184 286 LESGmignrsGCLLLMYEQMHILSPLVLpRDFYFLRYCQQIELGTWVXVDVSHKFPKES--SSNQSRSWRLPSGCLIKDMTNGCSKVTWIEHVEVD 379
                    **************************966*********************888887775..6899999**************************** PP

                    SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
          START 174 grlp.hwllrslvksglaegaktwvatlqrqcek 206
                    +++  h l+r l  s++a ga +w  tl+r ce+
  MDP0000125184 380 DKTQtHRLYRDLXCSSVAYGAERWIITLKRMCER 413
                    *9998***************************96 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.602.3E-20980IPR009057Homeodomain-like
SuperFamilySSF466891.09E-171178IPR009057Homeodomain-like
PROSITE profilePS5007116.7791878IPR001356Homeobox domain
SMARTSM003891.7E-162082IPR001356Homeobox domain
PfamPF000469.1E-172276IPR001356Homeobox domain
CDDcd000869.02E-172279No hitNo description
PROSITE profilePS5084845.333181416IPR002913START domain
SuperFamilySSF559611.1E-31182414No hitNo description
CDDcd088751.59E-104185412No hitNo description
SMARTSM002347.5E-31190413IPR002913START domain
PfamPF018528.1E-37191413IPR002913START domain
Gene3DG3DSA:3.30.530.201.6E-8246377IPR023393START-like domain
SuperFamilySSF559616.87E-15441642No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003677Molecular FunctionDNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 679 aa     Download sequence    Send to blast
MELSGNGGAS SDEASNSRRG NKKYHRHTNE QIQRLEEXFK HCAHPDDSQR QQLGRELGLE  60
PKQIKFWFQN KRTQTKAQSE RADNTILRQD NERIQCENYA MREALKNVSC PTCGGPPFGE  120
EERQINLQSL QLENAYLKEE AIGSTLDLSP GCSINQGIIG SPPLDLNLTS PTFSYQLQEI  180
PEMEKTLMAD IAASALEELV KLFQIDEPLW VKSTAYGRYF LNRGNYDKIF PRTNQFKTSS  240
ARIESSKDSG VVTISAATLV DMFLDSNKWE ELFPTIVTKA KTIEVLESGM IGNRSGCLLL  300
MYEQMHILSP LVLPRDFYFL RYCQQIELGT WVXVDVSHKF PKESSSNQSR SWRLPSGCLI  360
KDMTNGCSKV TWIEHVEVDD KTQTHRLYRD LXCSSVAYGA ERWIITLKRM CERFDCLMDE  420
VESTCEFGGG KSSLIPLVXS PEGKRSVMKL SQRMVKNFCG MLSMAGKLDF PQLSEVNNSG  480
VRVSVRKSAE SGQPHGMIVS VATSLWLPLP SETVXNFFRD EKNRVQWDVL SNGNPVHEIA  540
NISTGTHPGN CISVIRPFIP TENNMLMLQE SYTDPLGSLF VYAPVDVPAL NVAVSGEDSS  600
NIPILPSGFV ISGDGRAEVT GDSGHSTAGG SLLTVAFQIL VSSPSTSKQM NMESVATVNT  660
LISSTVQKIK VALNCSSLD
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: During embryo development, expressed in all cells at the 4- and 16-cell embryo stages. Expression is restricted to the protoderm from the globular stage onward. {ECO:0000269|PubMed:25564655}.
UniprotTISSUE SPECIFICITY: Expressed in apical meristems and young epidermal tissue including trichomes and stipules. Expressed in lateral root tips, the L1 layer of apical inflorescence meristems and early flower primordia, carpel and petal epidermis, stigma papillae, ovule primordia, nucellus and embryo. {ECO:0000269|PubMed:16778018}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028964478.10.0homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A251PUX60.0A0A251PUX6_PRUPE; Uncharacterized protein
STRINGXP_008348615.10.0(Malus domestica)
STRINGXP_008358175.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF10263398
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]