PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lus10023392

Organism

Linum usitatissimum

Taxonomic ID

4006

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum

Family

LSD

Protein Properties

Length: 182aa MW: 18816.6 Da PI: 8.3222

Description

LSD family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Lus10023392	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-LSD1	37.9	2.8e-12	7	30	1	24
zf-LSD1 1 CggCrtlLsYPrGApsVRCalCdt 24 C+gCr +L YPrGA++V+CalC+t Lus10023392 7 CSGCRSVLLYPRGASNVCCALCNT 30 ***********************8 PP
2	zf-LSD1	49.6	6.4e-16	46	70	1	25
zf-LSD1 1 CggCrtlLsYPrGApsVRCalCdtV 25 CggCrtlL+Y+rGA+sVRC++C+tV Lus10023392 46 CGGCRTLLMYTRGATSVRCSCCHTV 70 ************************9 PP
3	zf-LSD1	40.6	4.1e-13	84	108	1	25
zf-LSD1 1 CggCrtlLsYPrGApsVRCalCdtV 25 Cg+Crt+L YP GApsV+Ca+C+ V Lus10023392 84 CGNCRTMLVYPEGAPSVKCAVCHYV 108 **********************987 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
TIGRFAMs	TIGR01053	2.0E-12	4	34	IPR005735	Zinc finger, LSD1-type
Pfam	PF06943	1.8E-10	7	30	IPR005735	Zinc finger, LSD1-type
SuperFamily	SSF48695	6.56E-5	21	107	IPR011031	Multihaem cytochrome
TIGRFAMs	TIGR01053	1.0E-17	43	72	IPR005735	Zinc finger, LSD1-type
Pfam	PF06943	2.7E-13	46	70	IPR005735	Zinc finger, LSD1-type
Gene3D	G3DSA:3.30.40.10	9.9E-4	60	110	IPR013083	Zinc finger, RING/FYVE/PHD-type
TIGRFAMs	TIGR01053	2.7E-13	81	109	IPR005735	Zinc finger, LSD1-type
Pfam	PF06943	7.1E-13	84	108	IPR005735	Zinc finger, LSD1-type

Sequence ? help Back to Top
Protein Sequence Length: 182 aa Download sequence Send to blast
MQSQLVCSGC RSVLLYPRGA SNVCCALCNT LTAVPAPGLE LAQIICGGCR TLLMYTRGAT 60 SVRCSCCHTV NLAPVSSQIA HINCGNCRTM LVYPEGAPSV KCAVCHYVTD AGMGNGRVQP 120 PVNRPNSAGS AVSYTASSYP PQSPSSQTSQ TQTVVVENPM SVNESGKLVS NVVVGVTTDK 180 K*

Functional Description ? help Back to Top
Source	Description
UniProt	Negative regulator of reactive oxygen-induced cell death, cold stress-induced cell death, pathogen-induced hypersensitive response (HR), basal disease resistance. May be involved in the induction of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death. Antagonizes the function of BZIP10, a positive regulator of cell death, by interacting in the cytoplasm and preventing its nuclear localization. Controls lysigenous aerenchyma in hypocotyls under root hypoxia. Required for leaf acclimation in response to excess excitation energy. {ECO:0000269\|PubMed:10550898, ECO:0000269\|PubMed:11595797, ECO:0000269\|PubMed:11844114, ECO:0000269\|PubMed:12732715, ECO:0000269\|PubMed:15347794, ECO:0000269\|PubMed:16957775, ECO:0000269\|PubMed:18055613, ECO:0000269\|PubMed:18790826, ECO:0000269\|PubMed:20456049, ECO:0000269\|PubMed:21097903}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Lus10023392

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By methyl viologen. {ECO:0000269\|PubMed:20456049}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_012075549.1	5e-93	protein LSD1 isoform X1
Refseq	XP_022714636.1	8e-93	vacuolar protein sorting-associated protein 2 homolog 2-like
Swissprot	P94077	8e-69	LSD1_ARATH; Protein LSD1
TrEMBL	A0A067KSR6	1e-91	A0A067KSR6_JATCU; Uncharacterized protein
STRING	Lus10023392	1e-127	(Linum usitatissimum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF4027	33	61

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G20380.7	1e-69	LSD family protein

Link Out ? help Back to Top
Phytozome	Lus10023392

Publications ? help Back to Top
Spedaletti V, et al. Characterization of a lysine-specific histone demethylase from Arabidopsis thaliana. Biochemistry, 2008. 47(17): p. 4936-47 [PMID:18393445] Szechyńska-Hebda M,Czarnocka W,Hebda M,Bernacki MJ,Karpiński S PAD4, LSD1 and EDS1 regulate drought tolerance, plant biomass production, and cell wall properties. Plant Cell Rep., 2016. 35(3): p. 527-39 [PMID:26754794] Czarnocka W, et al. The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator. Plant Cell Environ., 2017. 40(11): p. 2644-2662 [PMID:28555890] Bernacki MJ, et al. LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana. Physiol Plant, 2019. 165(2): p. 369-382 [PMID:30461017]