PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lus10021298

Organism

Linum usitatissimum

Taxonomic ID

4006

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum

Family

E2F/DP

Protein Properties

Length: 493aa MW: 54687.6 Da PI: 4.9818

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Lus10021298	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	85.6	3.7e-27	173	237	1	70
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 r+++sL+llt+kf++l++ +e+gi++ln++a++L dv ++RRiYDi+NVLe+++liek+ kn+irwk Lus10021298 173 RYDSSLGLLTKKFVNLIKDAEDGIIDLNKAAETL---DV--QKRRIYDITNVLEGIGLIEKTLKNRIRWK 237 6899****************************.....****************************8 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	9.5E-28	170	239	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.45E-17	173	236	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.7E-33	173	238	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	8.0E-24	175	237	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	4.97E-32	251	355	No hit	No description
CDD	cd14660	3.23E-47	252	355	No hit	No description
Pfam	PF16421	3.9E-33	254	353	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 493 aa Download sequence Send to blast
MSDGAPASSH PPLPSAPSSG PILPPPRRHL AFVSMKPPFV APDDYHRFNS PAVSKVADQE 60 AEAIVVRAPV TLKRKLDDNG IESSKWTSSP GKTDASSSPY HTPVSAKGRT NNKPKSTKGN 120 KSVPRVPMLN PGETLQLSLC VLVFFLPSTF EIVWFSYLVC CSPSTLTPAG SCRYDSSLGL 180 LTKKFVNLIK DAEDGIIDLN KAAETLDVQK RRIYDITNVL EGIGLIEKTL KNRIRWKSVD 240 SSNSGNPDGN YSLLQAEIKK LSLEEQNLDN QIREMQERIR SFSEDENNQK WLFVTEDDIK 300 SLPCFMNETL IAIKAPHGTT MEVPDPDEAV DYPQRRYRII LRSTMGPIDV YLVSQFEENY 360 EEANDAGPSS VANASSSSSS VNPQMEMFPK QGTQNAVEPP PVQDLHHMFS DLNPSEEFVR 420 GMMKIVPTDA DNELDYWLRS DIADVSITDM WRTDSSFPEF YPSPSTPPRP AQFGMADVHT 480 PRPQTPPSRV VE*

Sequence ? help Back to Top

Protein Sequence Length: 493 aa Download sequence Send to blast

MSDGAPASSH PPLPSAPSSG PILPPPRRHL AFVSMKPPFV APDDYHRFNS PAVSKVADQE  60
AEAIVVRAPV TLKRKLDDNG IESSKWTSSP GKTDASSSPY HTPVSAKGRT NNKPKSTKGN  120
KSVPRVPMLN PGETLQLSLC VLVFFLPSTF EIVWFSYLVC CSPSTLTPAG SCRYDSSLGL  180
LTKKFVNLIK DAEDGIIDLN KAAETLDVQK RRIYDITNVL EGIGLIEKTL KNRIRWKSVD  240
SSNSGNPDGN YSLLQAEIKK LSLEEQNLDN QIREMQERIR SFSEDENNQK WLFVTEDDIK  300
SLPCFMNETL IAIKAPHGTT MEVPDPDEAV DYPQRRYRII LRSTMGPIDV YLVSQFEENY  360
EEANDAGPSS VANASSSSSS VNPQMEMFPK QGTQNAVEPP PVQDLHHMFS DLNPSEEFVR  420
GMMKIVPTDA DNELDYWLRS DIADVSITDM WRTDSSFPEF YPSPSTPPRP AQFGMADVHT  480
PRPQTPPSRV VE*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-22	168	239	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Lus10021298

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_012074348.1	0.0	transcription factor E2FA
Swissprot	Q9FNY0	1e-146	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A067KIS9	0.0	A0A067KIS9_JATCU; Uncharacterized protein
STRING	Lus10021298	0.0	(Linum usitatissimum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-143	E2F transcription factor 3

Link Out ? help Back to Top
Phytozome	Lus10021298

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]