PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lsa011706

Organism

Lactuca sativa

Taxonomic ID

4236

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca

Family

ARR-B

Protein Properties

Length: 585aa MW: 64208.9 Da PI: 6.1721

Description

ARR-B family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
gnl\|UG\|Lsa#S58693698	PU_ref	Unigene	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	G2-like	87.8	1e-27	215	268	1	55
G2-like 1 kprlrWtpeLHerFveaveqLGGsekAtPktilelmkvkgLtlehvkSHLQkYRl 55 kpr++W eLH++Fv av+qL G++kA+Pk+il+lm+v+g+t+e+v+SHLQkYRl Lsa011706 215 KPRVVWCVELHQQFVAAVNQL-GIDKAVPKKILDLMNVPGITRENVASHLQKYRL 268 79*****************.******************************8 PP
2	Response_reg	79.4	1.2e-26	29	137	1	109
EEEESSSHHHHHHHHHHHHHTTCEEEEEESSHHHHHHHHHHHH..ESEEEEESSCTTSEHHHHHHHHHHHTTTSEEEEEESTTTHHHHHHHHHTTES CS Response_reg 1 vlivdDeplvrellrqalekegyeevaeaddgeealellkekd..pDlillDiempgmdGlellkeireeepklpiivvtahgeeedalealkaGak 95 vl+vdD+p+ +++l+++l++ +y ev+ + +e al ll+e++ +D+++ D+ mp+mdG++ll +i e +lp+i+++a ++++ + + + Ga Lsa011706 29 VLVVDDDPTCLMILEKMLRNCKY-EVTKCNRAEVALSLLRENKngFDVVISDVHMPDMDGFKLLVHIGLEM-DLPVIMMSADDSKSVVMKGVTHGAC 123 89*******************.***********999999******************6654.8******************** PP EEEESS--HHHHHH CS Response_reg 96 dflsKpfdpeelvk 109 d+l Kp+ +e+l++ Lsa011706 124 DYLIKPVRIEALRN 137 *********987 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PIRSF	PIRSF036392	1.6E-165	6	579	IPR017053	Response regulator B-type, plant
SuperFamily	SSF52172	1.04E-35	26	149	IPR011006	CheY-like superfamily
Gene3D	G3DSA:3.40.50.2300	3.2E-42	26	163	No hit	No description
SMART	SM00448	5.9E-30	27	139	IPR001789	Signal transduction response regulator, receiver domain
PROSITE profile	PS50110	41.645	28	143	IPR001789	Signal transduction response regulator, receiver domain
Pfam	PF00072	9.1E-24	29	137	IPR001789	Signal transduction response regulator, receiver domain
CDD	cd00156	5.25E-27	30	142	No hit	No description
SuperFamily	SSF46689	8.96E-19	213	272	IPR009057	Homeodomain-like
Gene3D	G3DSA:1.10.10.60	6.1E-29	214	273	IPR009057	Homeodomain-like
TIGRFAMs	TIGR01557	1.4E-23	215	268	IPR006447	Myb domain, plants

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000160	Biological Process	phosphorelay signal transduction system
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 585 aa Download sequence Send to blast
MPSSSSVSRN STAGGDSNVP DQFPAGLRVL VVDDDPTCLM ILEKMLRNCK YEVTKCNRAE 60 VALSLLRENK NGFDVVISDV HMPDMDGFKL LVHIGLEMDL PVIMMSADDS KSVVMKGVTH 120 GACDYLIKPV RIEALRNIWQ HVVRKKKREW KDIDTSASLD DVDRKEEKQA EDPDYSSSAN 180 EGHNWKNTKR RKDDEDEGEG EGEGEERDDS SSLKKPRVVW CVELHQQFVA AVNQLGIDKA 240 VPKKILDLMN VPGITRENVA SHLQKYRLYL RRLSGSHQSG GNTPSFFSTP DAGYGSISTL 300 SDLEIQALAA SGQLGQLGQL PGQSLATLQA AALGRSGYSK SPISVPLIDQ RNIFSFENPQ 360 SRYGQVQNRQ GHNGNITRPM NLLHGIPTTM EPKQLVGMQG SFAGLTSQGL IPMTGQSQNH 420 GSRQPVLPGQ VVSSPGNHVT ESTGNRFQLR GNLGIPSYGL VNNGNQIQTR PLQGADLTFD 480 PSHHMNKNMH GGLNVLQHNN YDSGQKIGGN KVIFSTGEGS GTHVVDDSSM LKAEKVNYKS 540 TFCPEEYSQD DLLTAMFTQQ QQQEGIGQGE NELGLDWYSL DNLPV

Sequence ? help Back to Top

Protein Sequence Length: 585 aa Download sequence Send to blast

MPSSSSVSRN STAGGDSNVP DQFPAGLRVL VVDDDPTCLM ILEKMLRNCK YEVTKCNRAE  60
VALSLLRENK NGFDVVISDV HMPDMDGFKL LVHIGLEMDL PVIMMSADDS KSVVMKGVTH  120
GACDYLIKPV RIEALRNIWQ HVVRKKKREW KDIDTSASLD DVDRKEEKQA EDPDYSSSAN  180
EGHNWKNTKR RKDDEDEGEG EGEGEERDDS SSLKKPRVVW CVELHQQFVA AVNQLGIDKA  240
VPKKILDLMN VPGITRENVA SHLQKYRLYL RRLSGSHQSG GNTPSFFSTP DAGYGSISTL  300
SDLEIQALAA SGQLGQLGQL PGQSLATLQA AALGRSGYSK SPISVPLIDQ RNIFSFENPQ  360
SRYGQVQNRQ GHNGNITRPM NLLHGIPTTM EPKQLVGMQG SFAGLTSQGL IPMTGQSQNH  420
GSRQPVLPGQ VVSSPGNHVT ESTGNRFQLR GNLGIPSYGL VNNGNQIQTR PLQGADLTFD  480
PSHHMNKNMH GGLNVLQHNN YDSGQKIGGN KVIFSTGEGS GTHVVDDSSM LKAEKVNYKS  540
TFCPEEYSQD DLLTAMFTQQ QQQEGIGQGE NELGLDWYSL DNLPV

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1irz_A	1e-22	211	274	1	64	ARR10-B
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Regulates SHY2 by binding to its promoter (PubMed:19039136). Involved in the root-meristem size determination through the regulation of cell differentiation (PubMed:17363254). {ECO:0000269\|PubMed:11574878, ECO:0000269\|PubMed:11691951, ECO:0000269\|PubMed:17363254, ECO:0000269\|PubMed:19039136}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Down-regulated by gibberellin. {ECO:0000269\|PubMed:20605455}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023765654.1	0.0	two-component response regulator ARR1-like
Swissprot	Q940D0	1e-163	ARR1_ARATH; Two-component response regulator ARR1
TrEMBL	A0A2J6LAC3	0.0	A0A2J6LAC3_LACSA; Two-component response regulator
STRING	XP_004295112.1	0.0	(Fragaria vesca)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G16857.1	1e-148	response regulator 1

Publications ? help Back to Top
Bürkle L,Meyer S,Dortay H,Lehrach H,Heyl A In vitro recombination cloning of entire cDNA libraries in Arabidopsis thaliana and its application to the yeast two-hybrid system. Funct. Integr. Genomics, 2005. 5(3): p. 175-83 [PMID:15714319] Moubayidin L, et al. Spatial coordination between stem cell activity and cell differentiation in the root meristem. Dev. Cell, 2013. 26(4): p. 405-15 [PMID:23987513] Takahashi N, et al. Cytokinins control endocycle onset by promoting the expression of an APC/C activator in Arabidopsis roots. Curr. Biol., 2013. 23(18): p. 1812-7 [PMID:24035544] Kurepa J,Li Y,Perry SE,Smalle JA Ectopic expression of the phosphomimic mutant version of Arabidopsis response regulator 1 promotes a constitutive cytokinin response phenotype. BMC Plant Biol., 2014. 14: p. 28 [PMID:24423196] Cortleven A, et al. A novel protective function for cytokinin in the light stress response is mediated by the Arabidopsis histidine kinase2 and Arabidopsis histidine kinase3 receptors. Plant Physiol., 2014. 164(3): p. 1470-83 [PMID:24424319] Marín-de la Rosa N, et al. Genome Wide Binding Site Analysis Reveals Transcriptional Coactivation of Cytokinin-Responsive Genes by DELLA Proteins. PLoS Genet., 2015. 11(7): p. e1005337 [PMID:26134422] D'Alessandro S,Golin S,Hardtke CS,Lo Schiavo F,Zottini M The co-chaperone p23 controls root development through the modulation of auxin distribution in the Arabidopsis root meristem. J. Exp. Bot., 2015. 66(16): p. 5113-22 [PMID:26163704] Jiang L, et al. Strigolactones spatially influence lateral root development through the cytokinin signaling network. J. Exp. Bot., 2016. 67(1): p. 379-89 [PMID:26519957] Moubayidin L, et al. A SCARECROW-based regulatory circuit controls Arabidopsis thaliana meristem size from the root endodermis. Planta, 2016. 243(5): p. 1159-68 [PMID:26848984] Muraro D, et al. A multi-scale model of the interplay between cell signalling and hormone transport in specifying the root meristem of Arabidopsis thaliana. J. Theor. Biol., 2016. 404: p. 182-205 [PMID:27157127] Cortleven A, et al. Cytokinin Regulates the Etioplast-Chloroplast Transition through the Two-Component Signaling System and Activation of Chloroplast-Related Genes. Plant Physiol., 2016. 172(1): p. 464-78 [PMID:27388681] Kobayashi K, et al. Shoot Removal Induces Chloroplast Development in Roots via Cytokinin Signaling. Plant Physiol., 2017. 173(4): p. 2340-2355 [PMID:28193764] Zhang TQ, et al. A Two-Step Model for de Novo Activation of WUSCHEL during Plant Shoot Regeneration. Plant Cell, 2017. 29(5): p. 1073-1087 [PMID:28389585] Kushwah S,Laxmi A The interaction between glucose and cytokinin signaling in controlling Arabidopsis thaliana seedling root growth and development. Plant Signal Behav, 2017. 12(5): p. e1312241 [PMID:28467152] Meng WJ, et al. Type-B ARABIDOPSIS RESPONSE REGULATORs Specify the Shoot Stem Cell Niche by Dual Regulation of WUSCHEL. Plant Cell, 2017. 29(6): p. 1357-1372 [PMID:28576846] Kobayashi K,Iwase A Simultaneous but spatially different regulation of non-photosynthetic callus formation and photosynthetic root development after shoot removal. Plant Signal Behav, 2017. 12(6): p. e1338999 [PMID:28594268] Liu B,De Storme N,Geelen D Cold interferes with male meiotic cytokinesis in Arabidopsis thaliana independently of the AHK2/3-AHP2/3/5 cytokinin signaling module. Cell Biol. Int., 2017. 41(8): p. 879-889 [PMID:28618065] Zhang F,May A,Irish VF Type-B ARABIDOPSIS RESPONSE REGULATORs Directly Activate WUSCHEL. Trends Plant Sci., 2017. 22(10): p. 815-817 [PMID:28886911] Yan Z, et al. Type B Response Regulators Act As Central Integrators in Transcriptional Control of the Auxin Biosynthesis Enzyme TAA1. Plant Physiol., 2017. 175(3): p. 1438-1454 [PMID:28931628] Rong XF, et al. Type-B ARRs Control Carpel Regeneration Through Mediating AGAMOUS Expression in Arabidopsis. Plant Cell Physiol., 2018. 59(4): p. 756-764 [PMID:29186581] Bustillo-Avendaño E, et al. Regulation of Hormonal Control, Cell Reprogramming, and Patterning during De Novo Root Organogenesis. Plant Physiol., 2018. 176(2): p. 1709-1727 [PMID:29233938] Waldie T,Leyser O Cytokinin Targets Auxin Transport to Promote Shoot Branching. Plant Physiol., 2018. 177(2): p. 803-818 [PMID:29717021]