PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lsa005399

Organism

Lactuca sativa

Taxonomic ID

4236

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca

Family

ARR-B

Protein Properties

Length: 437aa MW: 48910.1 Da PI: 5.2039

Description

ARR-B family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
gnl\|UG\|Lsa#S58687962	PU_ref	Unigene	View CDS
PUT-187a-Lactuca_sativa-36813	PU_unref	plantGDB	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	G2-like	91.9	5.5e-29	218	271	1	55
G2-like 1 kprlrWtpeLHerFveaveqLGGsekAtPktilelmkvkgLtlehvkSHLQkYRl 55 kpr++W+ eLH++Fv av+qL G++kA+Pk+ilelm+v+gLt+e+v+SHLQkYRl Lsa005399 218 KPRVVWSVELHQQFVAAVNQL-GIDKAVPKRILELMNVPGLTRENVASHLQKYRL 271 79*****************.******************************8 PP
2	Response_reg	76	1.4e-25	30	138	1	109
EEEESSSHHHHHHHHHHHHHTTCEEEEEESSHHHHHHHHHHHH..ESEEEEESSCTTSEHHHHHHHHHHHTTTSEEEEEESTTTHHHHHHHHHTTES CS Response_reg 1 vlivdDeplvrellrqalekegyeevaeaddgeealellkekd..pDlillDiempgmdGlellkeireeepklpiivvtahgeeedalealkaGak 95 vl+vdD+p+ +++l+++l++ +y e++ + +e l ll+e++ +D++l D+ mp+mdG++ll++i e +lp+i+++a ++++ + + + Ga Lsa005399 30 VLVVDDDPTCLMILEKMLKNCNY-EATICNRAEIGLSLLRENKngHDIVLSDVHMPDMDGFKLLEHIGLEM-DLPVIMMSADDSNSVVMKGVTHGAC 124 89*******************.***********998889******************6654.8******************** PP EEEESS--HHHHHH CS Response_reg 96 dflsKpfdpeelvk 109 d+l Kp+ +e+l++ Lsa005399 125 DYLIKPVRIEALRN 138 *********987 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PIRSF	PIRSF036392	2.6E-160	11	423	IPR017053	Response regulator B-type, plant
Gene3D	G3DSA:3.40.50.2300	5.1E-41	27	151	No hit	No description
SuperFamily	SSF52172	5.83E-35	27	151	IPR011006	CheY-like superfamily
SMART	SM00448	2.4E-29	28	140	IPR001789	Signal transduction response regulator, receiver domain
PROSITE profile	PS50110	40.599	29	144	IPR001789	Signal transduction response regulator, receiver domain
Pfam	PF00072	9.9E-22	30	138	IPR001789	Signal transduction response regulator, receiver domain
CDD	cd00156	5.29E-27	31	143	No hit	No description
PROSITE profile	PS51294	10.59	215	274	IPR017930	Myb domain
SuperFamily	SSF46689	4.48E-20	216	275	IPR009057	Homeodomain-like
Gene3D	G3DSA:1.10.10.60	2.0E-30	217	276	IPR009057	Homeodomain-like
TIGRFAMs	TIGR01557	5.9E-25	218	271	IPR006447	Myb domain, plants
Pfam	PF00249	1.1E-7	220	270	IPR001005	SANT/Myb domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000160	Biological Process	phosphorelay signal transduction system
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 437 aa Download sequence Send to blast
MMLGSSCASW KPAGAGAGTV PDQFPAGLRV LVVDDDPTCL MILEKMLKNC NYEATICNRA 60 EIGLSLLREN KNGHDIVLSD VHMPDMDGFK LLEHIGLEMD LPVIMMSADD SNSVVMKGVT 120 HGACDYLIKP VRIEALRNIW QHVVRKRKHE WKDFEPEASP DVAAADAADQ HQKVPEDIDY 180 SSSANEERNW KNSKRKKDDE DEAEADAEER DESSSLKKPR VVWSVELHQQ FVAAVNQLGI 240 DKAVPKRILE LMNVPGLTRE NVASHLQKYR LYLRRLSSSQ HLGSTFLGSP DGGFASMTSF 300 TAGQFQSAVL ARSNNTKSPI SVPMMDQRNI FNFENPKLLH GIPTNMEPKQ FVGLQQSQQQ 360 QQLSYNNQIL IPVGGQTRSN GNRQPGNYRN DDLLQYPEQF NQDDLLTAIL KQQQQEAFGL 420 PENEFGFNGH GLDDLPV

Sequence ? help Back to Top

Protein Sequence Length: 437 aa Download sequence Send to blast

MMLGSSCASW KPAGAGAGTV PDQFPAGLRV LVVDDDPTCL MILEKMLKNC NYEATICNRA  60
EIGLSLLREN KNGHDIVLSD VHMPDMDGFK LLEHIGLEMD LPVIMMSADD SNSVVMKGVT  120
HGACDYLIKP VRIEALRNIW QHVVRKRKHE WKDFEPEASP DVAAADAADQ HQKVPEDIDY  180
SSSANEERNW KNSKRKKDDE DEAEADAEER DESSSLKKPR VVWSVELHQQ FVAAVNQLGI  240
DKAVPKRILE LMNVPGLTRE NVASHLQKYR LYLRRLSSSQ HLGSTFLGSP DGGFASMTSF  300
TAGQFQSAVL ARSNNTKSPI SVPMMDQRNI FNFENPKLLH GIPTNMEPKQ FVGLQQSQQQ  360
QQLSYNNQIL IPVGGQTRSN GNRQPGNYRN DDLLQYPEQF NQDDLLTAIL KQQQQEAFGL  420
PENEFGFNGH GLDDLPV

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1irz_A	9e-22	214	277	1	64	ARR10-B
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Regulates SHY2 by binding to its promoter (PubMed:19039136). Involved in the root-meristem size determination through the regulation of cell differentiation (PubMed:17363254). {ECO:0000269\|PubMed:11574878, ECO:0000269\|PubMed:11691951, ECO:0000269\|PubMed:17363254, ECO:0000269\|PubMed:19039136}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Down-regulated by gibberellin. {ECO:0000269\|PubMed:20605455}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023747092.1	0.0	two-component response regulator ARR2-like isoform X1
Swissprot	Q940D0	1e-139	ARR1_ARATH; Two-component response regulator ARR1
TrEMBL	A0A2J6JLT7	0.0	A0A2J6JLT7_LACSA; Two-component response regulator
STRING	Solyc05g054390.2.1	1e-163	(Solanum lycopersicum)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G16857.1	1e-130	response regulator 1

Publications ? help Back to Top
Bürkle L,Meyer S,Dortay H,Lehrach H,Heyl A In vitro recombination cloning of entire cDNA libraries in Arabidopsis thaliana and its application to the yeast two-hybrid system. Funct. Integr. Genomics, 2005. 5(3): p. 175-83 [PMID:15714319] Moubayidin L, et al. Spatial coordination between stem cell activity and cell differentiation in the root meristem. Dev. Cell, 2013. 26(4): p. 405-15 [PMID:23987513] Takahashi N, et al. Cytokinins control endocycle onset by promoting the expression of an APC/C activator in Arabidopsis roots. Curr. Biol., 2013. 23(18): p. 1812-7 [PMID:24035544] Kurepa J,Li Y,Perry SE,Smalle JA Ectopic expression of the phosphomimic mutant version of Arabidopsis response regulator 1 promotes a constitutive cytokinin response phenotype. BMC Plant Biol., 2014. 14: p. 28 [PMID:24423196] Cortleven A, et al. A novel protective function for cytokinin in the light stress response is mediated by the Arabidopsis histidine kinase2 and Arabidopsis histidine kinase3 receptors. Plant Physiol., 2014. 164(3): p. 1470-83 [PMID:24424319] Marín-de la Rosa N, et al. Genome Wide Binding Site Analysis Reveals Transcriptional Coactivation of Cytokinin-Responsive Genes by DELLA Proteins. PLoS Genet., 2015. 11(7): p. e1005337 [PMID:26134422] D'Alessandro S,Golin S,Hardtke CS,Lo Schiavo F,Zottini M The co-chaperone p23 controls root development through the modulation of auxin distribution in the Arabidopsis root meristem. J. Exp. Bot., 2015. 66(16): p. 5113-22 [PMID:26163704] Jiang L, et al. Strigolactones spatially influence lateral root development through the cytokinin signaling network. J. Exp. Bot., 2016. 67(1): p. 379-89 [PMID:26519957] Moubayidin L, et al. A SCARECROW-based regulatory circuit controls Arabidopsis thaliana meristem size from the root endodermis. Planta, 2016. 243(5): p. 1159-68 [PMID:26848984] Muraro D, et al. A multi-scale model of the interplay between cell signalling and hormone transport in specifying the root meristem of Arabidopsis thaliana. J. Theor. Biol., 2016. 404: p. 182-205 [PMID:27157127] Cortleven A, et al. Cytokinin Regulates the Etioplast-Chloroplast Transition through the Two-Component Signaling System and Activation of Chloroplast-Related Genes. Plant Physiol., 2016. 172(1): p. 464-78 [PMID:27388681] Kobayashi K, et al. Shoot Removal Induces Chloroplast Development in Roots via Cytokinin Signaling. Plant Physiol., 2017. 173(4): p. 2340-2355 [PMID:28193764] Zhang TQ, et al. A Two-Step Model for de Novo Activation of WUSCHEL during Plant Shoot Regeneration. Plant Cell, 2017. 29(5): p. 1073-1087 [PMID:28389585] Kushwah S,Laxmi A The interaction between glucose and cytokinin signaling in controlling Arabidopsis thaliana seedling root growth and development. Plant Signal Behav, 2017. 12(5): p. e1312241 [PMID:28467152] Meng WJ, et al. Type-B ARABIDOPSIS RESPONSE REGULATORs Specify the Shoot Stem Cell Niche by Dual Regulation of WUSCHEL. Plant Cell, 2017. 29(6): p. 1357-1372 [PMID:28576846] Kobayashi K,Iwase A Simultaneous but spatially different regulation of non-photosynthetic callus formation and photosynthetic root development after shoot removal. Plant Signal Behav, 2017. 12(6): p. e1338999 [PMID:28594268] Liu B,De Storme N,Geelen D Cold interferes with male meiotic cytokinesis in Arabidopsis thaliana independently of the AHK2/3-AHP2/3/5 cytokinin signaling module. Cell Biol. Int., 2017. 41(8): p. 879-889 [PMID:28618065] Zhang F,May A,Irish VF Type-B ARABIDOPSIS RESPONSE REGULATORs Directly Activate WUSCHEL. Trends Plant Sci., 2017. 22(10): p. 815-817 [PMID:28886911] Yan Z, et al. Type B Response Regulators Act As Central Integrators in Transcriptional Control of the Auxin Biosynthesis Enzyme TAA1. Plant Physiol., 2017. 175(3): p. 1438-1454 [PMID:28931628] Rong XF, et al. Type-B ARRs Control Carpel Regeneration Through Mediating AGAMOUS Expression in Arabidopsis. Plant Cell Physiol., 2018. 59(4): p. 756-764 [PMID:29186581] Bustillo-Avendaño E, et al. Regulation of Hormonal Control, Cell Reprogramming, and Patterning during De Novo Root Organogenesis. Plant Physiol., 2018. 176(2): p. 1709-1727 [PMID:29233938] Waldie T,Leyser O Cytokinin Targets Auxin Transport to Promote Shoot Branching. Plant Physiol., 2018. 177(2): p. 803-818 [PMID:29717021]