PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID WALNUT_00020862-RA
Organism
Juglans regia
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fagales; Juglandaceae; Juglans
Family E2F/DP
Protein Properties Length: 465aa    MW: 51778.7 Da    PI: 4.5956
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
WALNUT_00020862-RAgenomeJHUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.12.7e-27146211171
             E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                         r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  WALNUT_00020862-RA 146 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 211
                         6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.9E-29143213IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.3E-34146211IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.36E-17146209IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.0E-24148211IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440741.2E-34223328No hitNo description
CDDcd146601.24E-49225328No hitNo description
PfamPF164212.0E-34227326IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 465 aa     Download sequence    Send to blast
MSGSRTPTPS RPSPPEQIIQ QQQPLRRQLP FSSFKPPFGT PADYHRFADP PRGATDHEAE  60
AIVVKSPQLK RKSDTTDYEA DSVDRMAGPG FTEVVNSPLQ TPASVKGGKA NKTSRLSKCS  120
KSGPHTPVSN VGSPSGNNLT SAGPCRYDSS LGLLTKKFIN LIKHAEDGIL DLNKAAETLE  180
VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK GLDVSRPGEV DENYSSLQAE VENLSLQERK  240
LDEQIREMQD RLRDLSEDEN NQKWLFVTEE DIKGLPCFQN ETLIAIKAPH GTTLEVPDPD  300
EAVDYPQRRY RIVLRSTMGP IDVYLVSQFE EKFEEINDVE VPPNLPSSSG FDENLANTMV  360
TEECRGKEIE MHGQDAHRMC SDLNASNDFV SGIMKIVPSE VDSDADYWLL SDADVSITDI  420
WRTEQWNDFS TFQDDYTMAN ISTPQPQTPP SGATEGPPAA NPTKS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-25144212574PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018848381.10.0PREDICTED: transcription factor E2FB
SwissprotQ9FV711e-159E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A2I4GWU70.0A0A2I4GWU7_JUGRE; transcription factor E2FB
STRINGXP_006424133.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.31e-162E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]