PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Itr_sc000784.1_g00004.1

Organism

Ipomoea trifida

Taxonomic ID

35884

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Convolvulaceae; Ipomoeeae; Ipomoea

Family

E2F/DP

Protein Properties

Length: 505aa MW: 55196.2 Da PI: 4.8607

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Itr_sc000784.1_g00004.1	genome	Kazusa	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.6	1.9e-27	182	247	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+g+++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Itr_sc000784.1_g00004.1 182 RYDSSLGLLTKKFINLIKHAEDGMIDLNNAADAL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 247 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	5.2E-29	181	249	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	4.62E-17	182	245	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.3E-34	182	247	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.9E-24	184	247	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	8.89E-32	261	364	No hit	No description
CDD	cd14660	7.19E-46	263	364	No hit	No description
Pfam	PF16421	5.3E-32	263	362	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 505 aa Download sequence Send to blast
MSGTPTRAAA PPPAPSNAPP ANGVSGAQIP RPTRRHLAFA SMKPPFVPPE DYHRFSTPGA 60 DVGLAAGNNH QPEAIIVKSP ALEGGTQTIT TYSFIMCRNV FYWCVQPMKR KGRAASCEAE 120 SSEWSASPGY TDMVNSPLQT PVSVKGGKAY GRSKTTKNNR SGPPTPVSNA ACPSPLTPVG 180 CRYDSSLGLL TKKFINLIKH AEDGMIDLNN AADALEVQKR RIYDITNVLE GIGLIEKKLK 240 NRIQWKGVDA SRPGDVDTDA TILRAEVENL SMEEQRLDGR IREMQEKLRG LSEDENDKRW 300 LFVTEEDIKT IPCFQNETLI AIKAPHGTTL EVPEPDEAVD YPQRRYRIIL RSTMGPIDVY 360 LVSQFEEKFE EMTGVEPSMS VPLASSSGSN DNPSTDRSTV TNNLPGNGSL AHDSQMSCDL 420 GASLEFNGGM MKIVPSDADN NTDYWLQSDP IPGLSLTEMW KTDGDIDWCM ENMLNEFGIS 480 EISTPRPQTP SAVADVPPAV NMPPR

Sequence ? help Back to Top

Protein Sequence Length: 505 aa Download sequence Send to blast

MSGTPTRAAA PPPAPSNAPP ANGVSGAQIP RPTRRHLAFA SMKPPFVPPE DYHRFSTPGA  60
DVGLAAGNNH QPEAIIVKSP ALEGGTQTIT TYSFIMCRNV FYWCVQPMKR KGRAASCEAE  120
SSEWSASPGY TDMVNSPLQT PVSVKGGKAY GRSKTTKNNR SGPPTPVSNA ACPSPLTPVG  180
CRYDSSLGLL TKKFINLIKH AEDGMIDLNN AADALEVQKR RIYDITNVLE GIGLIEKKLK  240
NRIQWKGVDA SRPGDVDTDA TILRAEVENL SMEEQRLDGR IREMQEKLRG LSEDENDKRW  300
LFVTEEDIKT IPCFQNETLI AIKAPHGTTL EVPEPDEAVD YPQRRYRIIL RSTMGPIDVY  360
LVSQFEEKFE EMTGVEPSMS VPLASSSGSN DNPSTDRSTV TNNLPGNGSL AHDSQMSCDL  420
GASLEFNGGM MKIVPSDADN NTDYWLQSDP IPGLSLTEMW KTDGDIDWCM ENMLNEFGIS  480
EISTPRPQTP SAVADVPPAV NMPPR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-23	175	248	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_019176266.1	0.0	PREDICTED: transcription factor E2FA-like
Swissprot	Q9FNY0	1e-148	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A484LT20	0.0	A0A484LT20_9ASTE; Uncharacterized protein
STRING	PGSC0003DMT400042347	0.0	(Solanum tuberosum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1077	24	84

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-150	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]