PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Itr_sc000054.1_g00032.1

Organism

Ipomoea trifida

Taxonomic ID

35884

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Convolvulaceae; Ipomoeeae; Ipomoea

Family

E2F/DP

Protein Properties

Length: 442aa MW: 48712.1 Da PI: 4.4543

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Itr_sc000054.1_g00032.1	genome	Kazusa	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	87	1.4e-27	121	186	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l+++se+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Itr_sc000054.1_g00032.1 121 RYDSSLGLLTKKFINLIKHSEDGILDLNNAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 186 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	5.4E-29	119	188	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.2E-34	121	186	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.04E-17	121	184	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.5E-24	123	186	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	3.36E-49	196	302	No hit	No description
SuperFamily	SSF144074	1.12E-33	198	302	No hit	No description
Pfam	PF16421	8.2E-34	201	300	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 442 aa Download sequence Send to blast
MQQQQAIKRQ QLPFTAAKPP FGDYHRFAAD PRMLPPQVPE GIVVKTPPLK RKKETAKYSL 60 VSGELNQGSG YSDANGPLQT PVSGKAQKAS RASKANRSAS QTAGNVGSPS SNNATPVGAC 120 RYDSSLGLLT KKFINLIKHS EDGILDLNNA ADTLEVQKRR IYDITNVLEG IGLIEKKLKN 180 RIQWKGLDVS STGEDESVAS LQAEVENLTM DERRIDEQIR EMQERLRDLS EDENNQRWLF 240 VTEEDIKNIP SFQDETLIAI KAPHGTTLEV PDPDEAVDYL QRRYRIVLRS TMGPIDVYLV 300 SQFEEKYEEI DAAAAPPNNP STSGADNNAT ATLEIEKSGV NEVGRQENET GTIPSDLGTS 360 EDFMGGIMKI VPDVDNGTDY WFMSDYAGIT AIWEDSHLAG LDWSDLITLD EDHTTTNVNT 420 PHAQTSPPTF AELPCATNTT IS

Sequence ? help Back to Top

Protein Sequence Length: 442 aa Download sequence Send to blast

MQQQQAIKRQ QLPFTAAKPP FGDYHRFAAD PRMLPPQVPE GIVVKTPPLK RKKETAKYSL  60
VSGELNQGSG YSDANGPLQT PVSGKAQKAS RASKANRSAS QTAGNVGSPS SNNATPVGAC  120
RYDSSLGLLT KKFINLIKHS EDGILDLNNA ADTLEVQKRR IYDITNVLEG IGLIEKKLKN  180
RIQWKGLDVS STGEDESVAS LQAEVENLTM DERRIDEQIR EMQERLRDLS EDENNQRWLF  240
VTEEDIKNIP SFQDETLIAI KAPHGTTLEV PDPDEAVDYL QRRYRIVLRS TMGPIDVYLV  300
SQFEEKYEEI DAAAAPPNNP STSGADNNAT ATLEIEKSGV NEVGRQENET GTIPSDLGTS  360
EDFMGGIMKI VPDVDNGTDY WFMSDYAGIT AIWEDSHLAG LDWSDLITLD EDHTTTNVNT  420
PHAQTSPPTF AELPCATNTT IS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	8e-25	121	187	7	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_019199609.1	0.0	PREDICTED: transcription factor E2FB-like
Swissprot	Q9FV71	1e-145	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A0V0II58	0.0	A0A0V0II58_SOLCH; Putative transcription factor E2FB-like
STRING	Solyc11g068800.1.1	0.0	(Solanum lycopersicum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1077	24	84

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.2	1e-133	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]