PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

MLOC_70470.2

Organism

Hordeum vulgare

Taxonomic ID

4513

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum

Family

E2F/DP

Protein Properties

Length: 349aa MW: 39335 Da PI: 4.3887

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MLOC_70470.2	genome	IBSC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	78.6	5.6e-25	44	103	7	71
E2F_TDP 7 rlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 +llt+kf++ll+++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liek+ kn+irwkg MLOC_70470.2 44 GLLTKKFINLLKQAEDGILDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWKG 103 79************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM01372	6.4E-28	42	103	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.72E-16	43	104	IPR011991	Winged helix-turn-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	1.9E-25	44	105	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	2.5E-22	44	103	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	5.06E-47	113	219	No hit	No description
SuperFamily	SSF144074	4.45E-33	116	219	No hit	No description
Pfam	PF16421	1.4E-32	118	217	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 349 aa Download sequence Send to blast
MAISLTPHSY VPCRLGSFRI WLHLNLCSML LCTATYIYPD PSSGLLTKKF INLLKQAEDG 60 ILDLNNAAET LEVQKRRIYD ITNVLEGIGL IEKTLKNRIR WKGLDDSGVE LDNGLSGLQT 120 EVENLNLQEQ ALDERISDMR EKLRGLTEDE NSQRWLYVTE DDIKGLPCFQ NETLIAIKAP 180 HGTTLEVPDP DEAGDYLQRR YRIVLRSTLG PIDVYLVSQF DDGFENLGGA ATPPRHTNVP 240 EHGPCEDLHA TYATQSSKSI NVEYNIQHRQ NTPQDPTSND YGGMTRIIPS DVNTDADYWL 300 LTEGDVSITD MWETAPEVQW DTAVFLPEDV SSPHAHHSPR MEVPSMDQP

Sequence ? help Back to Top

Protein Sequence Length: 349 aa Download sequence Send to blast

MAISLTPHSY VPCRLGSFRI WLHLNLCSML LCTATYIYPD PSSGLLTKKF INLLKQAEDG  60
ILDLNNAAET LEVQKRRIYD ITNVLEGIGL IEKTLKNRIR WKGLDDSGVE LDNGLSGLQT  120
EVENLNLQEQ ALDERISDMR EKLRGLTEDE NSQRWLYVTE DDIKGLPCFQ NETLIAIKAP  180
HGTTLEVPDP DEAGDYLQRR YRIVLRSTLG PIDVYLVSQF DDGFENLGGA ATPPRHTNVP  240
EHGPCEDLHA TYATQSSKSI NVEYNIQHRQ NTPQDPTSND YGGMTRIIPS DVNTDADYWL  300
LTEGDVSITD MWETAPEVQW DTAVFLPEDV SSPHAHHSPR MEVPSMDQP

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	1e-21	40	104	9	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	MLOC_70470.2

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK366396	0.0	AK366396.1 Hordeum vulgare subsp. vulgare mRNA for predicted protein, complete cds, clone: NIASHv2042K03.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_020183251.1	0.0	transcription factor E2FA-like isoform X1
Swissprot	Q9FNY0	1e-101	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A446VDW3	0.0	A0A446VDW3_TRITD; Uncharacterized protein
STRING	MLOC_70470.2	0.0	(Hordeum vulgare)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP625	37	148

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-106	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]