PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MLOC_67050.3
Organism
Hordeum vulgare
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum
Family E2F/DP
Protein Properties Length: 219aa    MW: 24418.5 Da    PI: 5.0499
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MLOC_67050.3genomeIBSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.72e-231681171
       E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                  rk+ksL+ll+++f++l+ + + ++v l+++a++L    v  +rRRiYDi+NVLe+++++ +++kn+++w+g
  MLOC_67050.3 16 RKQKSLGLLCSNFVALYDRDDVETVGLDDAARRL---GV--ERRRIYDIVNVLESVGILVRRAKNRYTWIG 81
                  79****************9999************...**..****************************98 PP
2E2F_TDP28.42.8e-09161203138
       E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....d 38 
                   rkeksL+lltq+f+kl+ + e ++v+l+e+a+ L+ e     +
  MLOC_67050.3 161 RKEKSLGLLTQNFVKLFLTMEVETVSLDEAARLLLGErhaesN 203
                   79********************************998655444 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.5E-261282IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.17E-171580IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.6E-291681IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.4E-211781IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.2E-7159195IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013720.0042161208IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 219 aa     Download sequence    Send to blast
GSGAAARACR HHSYSRKQKS LGLLCSNFVA LYDRDDVETV GLDDAARRLG VERRRIYDIV  60
NVLESVGILV RRAKNRYTWI GFEGVPAALK ELKERTLREM SGLAPPPEEP SATNVSDDED  120
EDDKLGDADG DADSEKLSQS LDNASDKPDA PMCPLRSVDH RKEKSLGLLT QNFVKLFLTM  180
EVETVSLDEA ARLLLGERHA ESNMRSQYLH FLYFMGSMA
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-28152083199Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapMLOC_67050.3
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK3753580.0AK375358.1 Hordeum vulgare subsp. vulgare mRNA for predicted protein, complete cds, clone: NIASHv3092B12.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_003564010.11e-125E2F transcription factor-like E2FE
SwissprotQ8LSZ49e-58E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLF2EGT11e-145F2EGT1_HORVV; Predicted protein
STRINGMLOC_67050.11e-147(Hordeum vulgare)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.18e-60DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]