PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID HL.SW.v1.0.G030613.1
Organism
Humulus lupulus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus
Family bHLH
Protein Properties Length: 432aa    MW: 48076.9 Da    PI: 7.2237
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
HL.SW.v1.0.G030613.1genomeHOPBASEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH30.37.5e-10266313455
                           HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                   HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                           +h+ +Er RR++i +++  L++l+P +    +k   Ka +L + ++Y++sLq
  HL.SW.v1.0.G030613.1 266 SHSLAERVRREKISERMKYLQDLVPGC----DKITGKAGMLDEIINYVQSLQ 313
                           8*************************9....899*****************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS512575123No hitNo description
SuperFamilySSF474597.98E-17260331IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000837.57E-10260317No hitNo description
PROSITE profilePS5088815.637262312IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.104.1E-17262329IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.5E-7266313IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.9E-9268318IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006351Biological Processtranscription, DNA-templated
GO:0009637Biological Processresponse to blue light
GO:0009911Biological Processpositive regulation of flower development
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 432 aa     Download sequence    Send to blast
MTSRTFPEML HCLSAPGNLA GSCTEFTVLE RQRARLKWQQ EECPHQQLQQ STYFSGSELG  60
GVYFQAHDDQ LHNIQEDSFK DLTVNRSVKP DQGFKNGWHE PDKINMPLFG IGSLSSSCGF  120
VSGTTNNPSP GIQMNGAISR TYSCPPKVAM GTATEELKAK ETVSPLEKLI SASGKQSFKK  180
RKTDKLQNSK IVEEDHESRD KRVKGSAEEG DSKITEQNST KNVSSNANNR DQSSSGDNSK  240
ENSKASEVQK PDYIHVRARR GQATDSHSLA ERVRREKISE RMKYLQDLVP GCDKITGKAG  300
MLDEIINYVQ SLQRQVEFLS MKLAAVNPRL DFNIDDLFAK EMFPTSTAGF ETLGMSAEMS  360
NSAYLQFNNQ GQQVVSSSGL EMAMNFPDMA CLRRTISAPI SIPEQFIDAS RYNVNTSIPS  420
HIYCIKKYDL F*
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that binds DNA to G box 5'-CACGTG-3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light. {ECO:0000269|PubMed:18988809, ECO:0000269|PubMed:24130508}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Accumulates strongly in response to blue light due to reduced preventing 26S proteasome-mediated degradation in an ADO1/ZTL and ADO2/LKP2 dependent manner, but levels decrease in the absence of blue light via 26S proteasome degradation (at protein level). {ECO:0000269|PubMed:24101505}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024030235.11e-170transcription factor bHLH63 isoform X1
SwissprotQ8GY612e-62BH063_ARATH; Transcription factor bHLH63
TrEMBLA0A2P5EKJ10.0A0A2P5EKJ1_TREOI; Basic helix-loop-helix transcription factor
STRINGXP_010088933.11e-165(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36183463
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G34530.17e-65cryptochrome-interacting basic-helix-loop-helix 1
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Yang D,Zhao W,Meng Y,Li H,Liu B
    A CIB1-LIKE transcription factor GmCIL10 from soybean positively regulates plant flowering.
    Sci China Life Sci, 2015. 58(3): p. 261-9
    [PMID:25651969]
  3. Katsura Y, et al.
    An optogenetic system for interrogating the temporal dynamics of Akt.
    Sci Rep, 2015. 5: p. 14589
    [PMID:26423353]
  4. Taslimi A, et al.
    Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase.
    Nat. Chem. Biol., 2016. 12(6): p. 425-30
    [PMID:27065233]
  5. Liu Q, et al.
    The Blue Light-Dependent Polyubiquitination and Degradation of Arabidopsis Cryptochrome2 Requires Multiple E3 Ubiquitin Ligases.
    Plant Cell Physiol., 2016. 57(10): p. 2175-2186
    [PMID:27516416]
  6. Pathak GP, et al.
    Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2.
    Nucleic Acids Res., 2017. 45(20): p. e167
    [PMID:28431041]
  7. Duan L, et al.
    Understanding CRY2 interactions for optical control of intracellular signaling.
    Nat Commun, 2017. 8(1): p. 547
    [PMID:28916751]
  8. Quejada JR, et al.
    Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1.
    Nucleic Acids Res., 2017. 45(20): p. e172
    [PMID:29040770]
  9. Liu Y, et al.
    CIB1 and CO interact to mediate CRY2-dependent regulation of flowering.
    EMBO Rep., 2019.
    [PMID:30126927]