PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

HL.SW.v1.0.G021378.1

Organism

Humulus lupulus

Taxonomic ID

3486

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus

Family

bHLH

Protein Properties

Length: 383aa MW: 41476.2 Da PI: 8.2927

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
HL.SW.v1.0.G021378.1	genome	HOPBASE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	40.5	4.7e-13	141	184	8	55
HHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 8 rErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 Er RR+++++ f++L llP++ +K +K++i+ +Av+YI++Lq HL.SW.v1.0.G021378.1 141 TERERRKKMRNMFANLHALLPQL----PPKADKSTIVDEAVNYIRNLQ 184 6*******************6....39****************9 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF47459	1.44E-15	132	194	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	13.789	133	183	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	5.1E-15	137	195	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	3.14E-13	138	188	No hit	No description
SMART	SM00353	4.7E-9	141	189	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	3.7E-10	141	184	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF55021	2.75E-5	283	334	No hit	No description
Gene3D	G3DSA:3.30.70.260	4.4E-4	284	334	No hit	No description
CDD	cd04873	9.42E-5	288	326	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009793	Biological Process	embryo development ending in seed dormancy
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 383 aa Download sequence Send to blast
MSQGGTVLLM GTETSFLQWD EKHTWLLPNT FSNSDNYSSG VAAAAADESC EKNKIAASNS 60 DSGGGHKATP VKELGLLSNN NKKRSRGTNV GVCNNKKGKK TSTTTTEDDQ PVKEGKGNGD 120 GSVSGSGSGG GESDHEIHIW TERERRKKMR NMFANLHALL PQLPPKADKS TIVDEAVNYI 180 RNLQQTLHKL QKQKLEKLQA GATNNLANTF TNNIGEPSIN NTTNNPQPKL VYDSREAYLA 240 DQGTCNELVS IGNNNNNNNN TNSLLPVLFQ TWTSSNVVLN ICGEEAHISV CSPKKPGLFT 300 SICYVLEKHK ISIISAQLSS DSNRIMYMIH AHASSIGTTK NKTLYREHVV GSKSSVQPRT 360 STDHNQHVLG IGCTEDNVIG IE*

Sequence ? help Back to Top

Protein Sequence Length: 383 aa Download sequence Send to blast

MSQGGTVLLM GTETSFLQWD EKHTWLLPNT FSNSDNYSSG VAAAAADESC EKNKIAASNS  60
DSGGGHKATP VKELGLLSNN NKKRSRGTNV GVCNNKKGKK TSTTTTEDDQ PVKEGKGNGD  120
GSVSGSGSGG GESDHEIHIW TERERRKKMR NMFANLHALL PQLPPKADKS TIVDEAVNYI  180
RNLQQTLHKL QKQKLEKLQA GATNNLANTF TNNIGEPSIN NTTNNPQPKL VYDSREAYLA  240
DQGTCNELVS IGNNNNNNNN TNSLLPVLFQ TWTSSNVVLN ICGEEAHISV CSPKKPGLFT  300
SICYVLEKHK ISIISAQLSS DSNRIMYMIH AHASSIGTTK NKTLYREHVV GSKSSVQPRT  360
STDHNQHVLG IGCTEDNVIG IE*

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that controls embryo growth (PubMed:18567831, PubMed:18849529, PubMed:23318634). Regulates endosperm breakdown and embryonic epidermal development. Regulates the expression of SBT2.4/ALE1 (PubMed:18849529, PubMed:23318634). Involved in embryonic cuticle formation upstream of SBT2.4/ALE1 (PubMed:23318634). Does not seem to be a general regulator of endosperm patterning. May control specific signaling pathways that coordinate embryo invasion and breakdown of surrounding endosperm tissues (PubMed:18849529). Required for the production the embryo sheath, an extracuticular endosperm-derived structure at the surface of the embryo. Acts upstream of KRS (PubMed:28696222). {ECO:0000269\|PubMed:18567831, ECO:0000269\|PubMed:18849529, ECO:0000269\|PubMed:23318634, ECO:0000269\|PubMed:28696222}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023922279.1	2e-91	transcription factor bHLH95
Swissprot	Q9FXA3	3e-52	BH095_ARATH; Transcription factor bHLH95
TrEMBL	A0A2P5E923	1e-136	A0A2P5E923_TREOI; Basic helix-loop-helix transcription factor
STRING	XP_010107919.1	1e-89	(Morus notabilis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF4773	33	58

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G49770.1	2e-40	bHLH family protein

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Zhang Y, et al. Reduced function of the RNA-binding protein FPA rescues a T-DNA insertion mutant in the Arabidopsis ZHOUPI gene by promoting transcriptional read-through. Plant Mol. Biol., 2016. 91(4-5): p. 549-61 [PMID:27164978] Fourquin C, et al. Mechanical stress mediated by both endosperm softening and embryo growth underlies endosperm elimination in Arabidopsis seeds. Development, 2016. 143(18): p. 3300-5 [PMID:27287798] Du Q,Wang H Retarded Embryo Development 1 (RED1) regulates embryo development, seed maturation and plant growth in Arabidopsis. J Genet Genomics, 2016. 43(7): p. 439-49 [PMID:27477025] Moussu S, et al. ZHOUPI and KERBEROS Mediate Embryo/Endosperm Separation by Promoting the Formation of an Extracuticular Sheath at the Embryo Surface. Plant Cell, 2017. 29(7): p. 1642-1656 [PMID:28696222]