PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID HL.SW.v1.0.G016897.1
Organism
Humulus lupulus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus
Family C2H2
Protein Properties Length: 456aa    MW: 51745.8 Da    PI: 6.4743
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
HL.SW.v1.0.G016897.1genomeHOPBASEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H211.10.0012160182323
                           ET..TTTEEESSHHHHHHHHHHT CS
               zf-C2H2   3 Cp..dCgksFsrksnLkrHirtH 23 
                           C+   Cgk+F +   L++H   H
  HL.SW.v1.0.G016897.1 160 CSyeSCGKTFIDAGALRKHSHIH 182
                           77779**************7766 PP
2zf-C2H216.13.1e-05187211123
                           EEET..TTTEEESSHHHHHHHHHHT CS
               zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                           y+C+   Cgk F ++s LkrH   H
  HL.SW.v1.0.G016897.1 187 YVCHyeGCGKKFLDSSKLKRHFLIH 211
                           9********************8877 PP
3zf-C2H221.36.8e-07217241123
                           EEET..TTTEEESSHHHHHHHHHHT CS
               zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                           ++Cp   Cgk Fs   nL++H++tH
  HL.SW.v1.0.G016897.1 217 FVCPheGCGKAFSLDFNLRSHMKTH 241
                           89**********************9 PP
4zf-C2H217.21.4e-05247271123
                           EEET..TTTEEESSHHHHHHHHHHT CS
               zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                           + Cp  dCgk++ + + Lk+Hi++H
  HL.SW.v1.0.G016897.1 247 HICPypDCGKRYAHEYKLKNHISSH 271
                           679999******************6 PP
5zf-C2H215.26.3e-05312337123
                           EEET..TTTEEESSHHHHHHHHHH.T CS
               zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                           y Cp   C+k + + + Lk H+r+ H
  HL.SW.v1.0.G016897.1 312 YACPyeGCDKAYIHEYKLKLHLRReH 337
                           89*********************999 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.160.603.6E-12153184IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015711.032158187IPR007087Zinc finger, C2H2
SMARTSM003550.037158182IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280160182IPR007087Zinc finger, C2H2
SuperFamilySSF576673.95E-8161211No hitNo description
Gene3DG3DSA:3.30.160.603.0E-14185207IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.0024187211IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015713.921187216IPR007087Zinc finger, C2H2
PROSITE patternPS000280189211IPR007087Zinc finger, C2H2
SuperFamilySSF576674.48E-13201244No hitNo description
Gene3DG3DSA:3.30.160.604.7E-20208241IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003553.1E-4217241IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015712.695217246IPR007087Zinc finger, C2H2
PROSITE patternPS000280219241IPR007087Zinc finger, C2H2
SuperFamilySSF576675.96E-8232272No hitNo description
Gene3DG3DSA:3.30.160.607.2E-9242273IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.0045247271IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.203247276IPR007087Zinc finger, C2H2
PROSITE patternPS000280249272IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.603.4E-9307335IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576671.55E-5307335No hitNo description
SMARTSM003550.0038312337IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.138312342IPR007087Zinc finger, C2H2
PROSITE patternPS000280314337IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045892Biological Processnegative regulation of transcription, DNA-templated
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 456 aa     Download sequence    Send to blast
METHFNHNLF ERRPILRSKA PAGSSTVALF LFEHVEMEIG KRVYGDKCGC RLAVKEIFGS  60
QKGQLKWSDV FCSHKVGGLS PSWVPVFKLE ILIQWEDDNS FDVEVSLQNG VPQDVVATGG  120
KCFLYKWVTE DTLKSLKEKA KEPEVPEPEP EPTTEVLFLC SYESCGKTFI DAGALRKHSH  180
IHGERQYVCH YEGCGKKFLD SSKLKRHFLI HTGERDFVCP HEGCGKAFSL DFNLRSHMKT  240
HSQENYHICP YPDCGKRYAH EYKLKNHISS HHEKSGTVDV TKYTPTPPPE KPARTPKPAA  300
GVYGSASSDR PYACPYEGCD KAYIHEYKLK LHLRREHPGH TSDENVENPA INAAHEIDEG  360
SDQDAYGGNR VHNGKSQKQN RPKPSVKLPP AKIAQRKGST PPPARVNIVK KPWPVKEEVY  420
EEDSEETEED RDNVEDGWRY AEHNEDDDEE TEYED*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ubd_C2e-331512712119PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtDual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269|PubMed:22508367, ECO:0000269|PubMed:24451981, ECO:0000269|PubMed:26961720}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269|PubMed:26961720}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010087411.10.0zinc finger transcription factor YY1
SwissprotQ2V3L31e-144YY1_ARATH; Zinc finger transcription factor YY1
TrEMBLA0A2P5BJ160.0A0A2P5BJ16_PARAD; TFIIH C1-like domain containing protein
STRINGXP_010087411.10.0(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF56493354
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G06634.11e-131C2H2 family protein
Publications ? help Back to Top
  1. Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H
    The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4.
    DNA Res., 2001. 8(6): p. 285-90
    [PMID:11853315]
  2. Li T,Wu XY,Li H,Song JH,Liu JY
    A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network.
    Mol Plant, 2016. 9(5): p. 650-661
    [PMID:26961720]
  3. Wu XY,Li T
    A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response.
    Front Plant Sci, 2017. 8: p. 323
    [PMID:28348572]