PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

HL.SW.v1.0.G014475.1

Organism

Humulus lupulus

Taxonomic ID

3486

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus

Family

E2F/DP

Protein Properties

Length: 304aa MW: 34206.6 Da PI: 8.7321

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
HL.SW.v1.0.G014475.1	genome	HOPBASE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	58.4	1.2e-18	18	89	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliek......kekneirwkg 71 rkeksL++l+++fl+l++++ g + l+e+a++L v +rRR YD++N+Le +++ + k+kn+++wkg HL.SW.v1.0.G014475.1 18 RKEKSLGVLCSNFLRLYNREGVGSIGLDEAASQL---GV--ERRRMYDVVNILEIIGVSSHnlvvarKAKNQYTWKG 89 79***************999********.....***********9997555555555******98 PP
2	E2F_TDP	47.1	3.9e-15	102	177	3	69
E2F_TDP 3 eksLrl.ltqkflklleksee.givtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirw 69 e++L+ ++ + ++ +s++ + + l+++ak L + ++k+RR+YDi+NVL+++nliek + k+++rw HL.SW.v1.0.G014475.1 102 EEGLKEnFSAS---VCCSSSRmDLILLENAAKGLPGDaddptALRTKVRRLYDIANVLSSMNLIEKirhpdSGKPAYRW 177 56665414555...77777777**********777*9999*****************999999***9 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	7.0E-21	16	90	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.3E-22	18	89	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.9E-10	18	87	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.4E-15	19	89	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SMART	SM01372	7.1E-9	100	179	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	3.2E-11	109	178	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.72E-8	115	178	IPR011991	Winged helix-turn-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	3.4E-11	142	178	IPR011991	Winged helix-turn-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 304 aa Download sequence Send to blast
MSSFMFMESD SRPNVYCRKE KSLGVLCSNF LRLYNREGVG SIGLDEAASQ LGVERRRMYD 60 VVNILEIIGV SSHNLVVARK AKNQYTWKGV GEIPRALEQL KEEGLKENFS ASVCCSSSRM 120 DLILLENAAK GLPGDADDPT ALRTKVRRLY DIANVLSSMN LIEKIRHPDS GKPAYRWLYW 180 GGKTKNEIDT SDTNQPKKRV FGADITNYNS KRKRGDTAED CKSNQEKSKQ TIANSTELEQ 240 NECDDEEVKQ HPKYASKGIV FGPFAPISLP MEGDAANKRV RQVQDWESLA STYRPQYRNQ 300 GTF*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	9e-15	18	113	4	97	Transcription factor E2F8
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	196	213	KKRVFGADITNYNSKRKR

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15308755}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_024018493.1	1e-137	E2F transcription factor-like E2FF
Swissprot	Q8RWL0	2e-74	E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBL	A0A2P5DRU5	1e-164	A0A2P5DRU5_TREOI; E2F Family
STRING	XP_010091943.1	1e-135	(Morus notabilis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF21774	3	4

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G01330.1	8e-77	DP-E2F-like protein 3

Publications ? help Back to Top
Dohmann EM, et al. The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability. Development, 2008. 135(11): p. 2013-22 [PMID:18434413]