PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID HL.SW.v1.0.G005787.1
Organism
Humulus lupulus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus
Family HD-ZIP
Protein Properties Length: 723aa    MW: 78927.6 Da    PI: 6.781
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
HL.SW.v1.0.G005787.1genomeHOPBASEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox63.62.9e-203085156
                          TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
              Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                          +++ +++t++q++ Le++F+++++p++++r +L+++lgL  rq+k+WFqNrR+++k
  HL.SW.v1.0.G005787.1 30 KKRYHRHTAHQIQKLESMFKECPHPDEKQRLQLSRELGLAPRQIKFWFQNRRTQMK 85
                          678899***********************************************998 PP
2START185.92.1e-582324582206
                           HHHHHHHHHHHHHHHC-TT-EEEE.....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S.. CS
                 START   2 laeeaaqelvkkalaeepgWvkss.....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetla.. 77 
                           +a  a++el+++ + +ep+W+ks+     + +n d + ++f+++++       ++ea+r+ gvv+m+   lv  ++d   +W   ++  
  HL.SW.v1.0.G005787.1 232 IATNAMEELLRLLQTNEPLWMKSAsgdgrDVLNLDSYDRIFPRANShmknpnLRIEASRDAGVVIMNGLALVDMFMDPI-KWVDLFPti 319
                           56789*******************9*999999**********9999***********************9999999999.999999999 PP

                           ..EEEEEEEECTT.......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEE CS
                 START  78 ..kaetlevissg.......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliep 156
                              a tlevissg       g+lqlm+ elq+lsplvp R+f+f+Ry++q ++g w+ivdvS d +++++  ++  R+++lpSg+li++
  HL.SW.v1.0.G005787.1 320 vsMARTLEVISSGmlgnshsGTLQLMYGELQVLSPLVPtREFYFLRYCQQIEQGLWAIVDVSYDFPRDNQ-FANQCRSHRLPSGCLIQD 407
                           9899*****************************************************************9.8***************** PP

                           ECTCEEEEEEEE-EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
                 START 157 ksnghskvtwvehvdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                           ++ng+skvtwveh++ ++++p h l+r lv+sgla+ga +w+atlqr ce+
  HL.SW.v1.0.G005787.1 408 MPNGYSKVTWVEHIEIEDKTPtHRLYRDLVHSGLAFGAERWLATLQRMCER 458
                           *************************************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466891.42E-201387IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.601.2E-222089IPR009057Homeodomain-like
PROSITE profilePS5007118.0742787IPR001356Homeobox domain
SMARTSM003892.3E-192891IPR001356Homeobox domain
CDDcd000864.29E-192988No hitNo description
PfamPF000467.5E-183085IPR001356Homeobox domain
PROSITE patternPS0002706285IPR017970Homeobox, conserved site
PROSITE profilePS5084852.219222461IPR002913START domain
SuperFamilySSF559611.37E-37223459No hitNo description
CDDcd088753.62E-120226457No hitNo description
SMARTSM002343.7E-53231458IPR002913START domain
PfamPF018521.8E-50232458IPR002913START domain
Gene3DG3DSA:3.30.530.205.9E-8301456IPR023393START-like domain
SuperFamilySSF559611.29E-25479714No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 723 aa     Download sequence    Send to blast
MEYASGGGGG SGGGGGGGGD NDASNAQRRK KRYHRHTAHQ IQKLESMFKE CPHPDEKQRL  60
QLSRELGLAP RQIKFWFQNR RTQMKAQHER ADNCALRAEN DKIRCENIAI REALKNVICP  120
SCGGPPINED SYFDDQKLRM ENAQLKEELD RVSSIAAKYI GRPISQLPPV QPIHISSLDL  180
SMASFAPQGM GMGVGGPSLD LDLLPGSSST MPVMPYQPPG ISDMDKSLMS DIATNAMEEL  240
LRLLQTNEPL WMKSASGDGR DVLNLDSYDR IFPRANSHMK NPNLRIEASR DAGVVIMNGL  300
ALVDMFMDPI KWVDLFPTIV SMARTLEVIS SGMLGNSHSG TLQLMYGELQ VLSPLVPTRE  360
FYFLRYCQQI EQGLWAIVDV SYDFPRDNQF ANQCRSHRLP SGCLIQDMPN GYSKVTWVEH  420
IEIEDKTPTH RLYRDLVHSG LAFGAERWLA TLQRMCERFA CLMVSGSSTR DLGGVIPSPD  480
GKKSMMKLAQ RMVNHFCASI STSNGHRWTT LSGLNEVGVR VTVHKSTDPG QPNGVVLSAA  540
TTIWLPVSPQ DVFNFFKDER TRSQWDVLSN GNAVQEVAHI ANGSHHGNCI SVLRAFNTSQ  600
NNMLILQESC IDSSGSMVVY CPVDLPAINI AMSGEDPSYI PLLPSGFTIS PDGRGSQGGG  660
DGASTSAAAS GQSGGSLITV AFQILVSSLP SAKLNLESVN TVNNLIGNTV QQIKASLNCP  720
NS*
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAM4671703e-39AM467170.2 Vitis vinifera contig VV78X070764.5, whole genome shotgun sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010099679.10.0homeobox-leucine zipper protein HDG11
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A2P5B2950.0A0A2P5B295_TREOI; Octamer-binding transcription factor
STRINGXP_010099679.10.0(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF10263398
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]