PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Han005414

Organism

Helianthus annuus

Taxonomic ID

4232

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Heliantheae alliance; Heliantheae; Helianthus

Family

C2H2

Protein Properties

Length: 272aa MW: 31494.2 Da PI: 8.3791

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
gnl\|UG\|Han#S48349872	PU_ref	Unigene	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	12.5	0.00045	47	69	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 y C+ C + +rk +L+rH++++ Han005414 47 YFCEFCLTFMKRKQQLQRHMKKC 69 78*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51726	73.682	13	272	IPR002717	Histone acetyltransferase domain, MYST-type
SuperFamily	SSF55729	2.61E-109	16	268	IPR016181	Acyl-CoA N-acyltransferase
Gene3D	G3DSA:3.30.60.60	1.3E-24	18	70	No hit	No description
Gene3D	G3DSA:3.40.630.30	1.4E-73	72	215	IPR016181	Acyl-CoA N-acyltransferase
Pfam	PF01853	1.7E-83	74	251	IPR002717	Histone acetyltransferase domain, MYST-type
CDD	cd04301	0.00212	125	183	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0016747	Molecular Function	transferase activity, transferring acyl groups other than amino-acyl groups

Sequence ? help Back to Top
Protein Sequence Length: 272 aa Download sequence Send to blast
LDAASLREHE EFTKVKNIAT IELGRYEIET WYFSPFPPEY NDCLNLYFCE FCLTFMKRKQ 60 QLQRHMKKCD LKHPPGDEIY RSGTLSMFEV DGKKNKVYGQ NLCYLAKLFL DHKTLYYDVD 120 LFLFYVLCEC DDRGCHMVGY FSKEKHSEES YNLACILTLP PYQRKGYGKF LIAFSYELSK 180 KEGKVGTPER PLSDLGLLSY RGYWTRVLLD ILKKHKGNIS IKELSDMTAI RAGDILATLQ 240 ALELIXYRKG QHVICADPKG VDRHLKAAGR GG

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4dnc_A	1e-117	9	268	1	260	Histone acetyltransferase KAT8
4dnc_B	1e-117	9	268	1	260	Histone acetyltransferase KAT8
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Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed in cotyledons, leaves, stems, roots and, at higher levels in developing flowers, particularly in the anthers and gynoecia (PubMed:19040736). Constitutively expressed in all tissues, predominantly in shoot apical meristem (PubMed:23273925). {ECO:0000269\|PubMed:19040736, ECO:0000269\|PubMed:23273925}.

Functional Description ? help Back to Top
Source	Description
UniProt	Histone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269\|PubMed:17877703, ECO:0000269\|PubMed:19040736, ECO:0000269\|PubMed:22170978, ECO:0000269\|PubMed:23273925}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269\|PubMed:22170978}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_022018813.1	0.0	histone acetyltransferase of the MYST family 2 isoform X2
Swissprot	Q9FLF7	0.0	MYST1_ARATH; Histone acetyltransferase of the MYST family 1
TrEMBL	A0A251VFE6	0.0	A0A251VFE6_HELAN; Histone acetyltransferase
STRING	GLYMA04G16180.1	0.0	(Glycine max)
STRING	Lus10001302	0.0	(Linum usitatissimum)
STRING	XP_006434100.1	0.0	(Citrus clementina)

Publications ? help Back to Top
Latrasse D, et al. The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis. BMC Plant Biol., 2008. 8: p. 121 [PMID:19040736] Campi M,D'Andrea L,Emiliani J,Casati P Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA. Plant Physiol., 2012. 158(2): p. 981-95 [PMID:22170978] Bari A,Orazova S,Ivashchenko A miR156- and miR171-binding sites in the protein-coding sequences of several plant genes. Biomed Res Int, 2013. 2013: p. 307145 [PMID:23936788] Xu Y, et al. Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes. Nucleic Acids Res., 2014. 42(17): p. 10960-74 [PMID:25183522] Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB 3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana. J Mol Model, 2016. 22(11): p. 256 [PMID:27709438] Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis. Front Plant Sci, 2017. 8: p. 1179 [PMID:28740501]