PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

KHN43750.1

Organism

Glycine soja

Taxonomic ID

3848

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Phaseoleae; Glycine; Soja

Family

bHLH

Protein Properties

Length: 371aa MW: 42162.5 Da PI: 5.1072

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
KHN43750.1	genome	TCUHK	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	38.3	2.5e-12	166	217	1	55
CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +r++h ++Er+RR+++N+ + Lr+l+P + + ++ + a+i A+e++++L+ KHN43750.1 166 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 217 79**************************...9***************9995 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
CDD	cd00083	4.14E-12	164	221	No hit	No description
Gene3D	G3DSA:4.10.280.10	1.2E-13	164	220	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	1.7E-16	165	231	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	15.428	165	216	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	1.1E-9	166	217	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	3.4E-9	171	222	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd04873	0.00468	297	361	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0055114	Biological Process	oxidation-reduction process
GO:0032440	Molecular Function	2-alkenal reductase [NAD(P)] activity
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 371 aa Download sequence Send to blast
MPQTTPPHGF YGATSAATTS YDKLSFADVM QFADFGPKLA LNQAKNCEES AIDPVYFLKF 60 PVLNNKMEED QQNMMMNNDD PDGDEAENHH HDERFNNLVS VEDKEGMMVR EDEETTRVSD 120 DNNSVQIRFL GHEEPQQKNN CAVQENKNGK RKRPRTVKTS EEVESQRMTH IAVERNRRKQ 180 MNEHLRVLRS LMPGSYVQRG DQASIIGGAI EFVRELEQLL QCLESQKRRR LLGEAQARQV 240 GDPSLATQQQ PPFFPPLPIP NEQMKLVEME TGLHEETAES KSCLADVEVK LLGFDAMIKI 300 LSRRRPGQLI KTIAALEDLQ LIILHTNITT IEQTVLYSFN VKVASDSRFT AEDIASSVQQ 360 IFNFIHANTS M

Sequence ? help Back to Top

Protein Sequence Length: 371 aa Download sequence Send to blast

MPQTTPPHGF YGATSAATTS YDKLSFADVM QFADFGPKLA LNQAKNCEES AIDPVYFLKF  60
PVLNNKMEED QQNMMMNNDD PDGDEAENHH HDERFNNLVS VEDKEGMMVR EDEETTRVSD  120
DNNSVQIRFL GHEEPQQKNN CAVQENKNGK RKRPRTVKTS EEVESQRMTH IAVERNRRKQ  180
MNEHLRVLRS LMPGSYVQRG DQASIIGGAI EFVRELEQLL QCLESQKRRR LLGEAQARQV  240
GDPSLATQQQ PPFFPPLPIP NEQMKLVEME TGLHEETAES KSCLADVEVK LLGFDAMIKI  300
LSRRRPGQLI KTIAALEDLQ LIILHTNITT IEQTVLYSFN VKVASDSRFT AEDIASSVQQ  360
IFNFIHANTS M

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	166	177	RMTHIAVERNRR
2	226	230	KRRRL

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269\|PubMed:17088607, ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267, ECO:0000269\|PubMed:24571519, ECO:0000269\|PubMed:24654956}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	KHN43750.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269\|PubMed:22442411}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AP015043	1e-159	AP015043.1 Vigna angularis var. angularis DNA, chromosome 10, almost complete sequence, cultivar: Shumari.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006573288.1	0.0	transcription factor FAMA
Refseq	XP_028234426.1	0.0	transcription factor FAMA-like
Swissprot	Q56YJ8	1e-145	FAMA_ARATH; Transcription factor FAMA
TrEMBL	A0A0B2SFI8	0.0	A0A0B2SFI8_GLYSO; Transcription factor FAMA
STRING	GLYMA01G23230.1	0.0	(Glycine max)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF10489	33	40

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G24140.1	1e-130	bHLH family protein

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Qi X, et al. Identification of a novel salt tolerance gene in wild soybean by whole-genome sequencing. Nat Commun, 2014. 5: p. 4340 [PMID:25004933] Matos JL, et al. Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] Chen L, et al. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] Li X,Yang R,Chen H The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]