PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KHN36247.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Phaseoleae; Glycine; Soja
Family AP2
Protein Properties Length: 494aa    MW: 54848.6 Da    PI: 8.1738
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KHN36247.1genomeTCUHKView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP253.46.2e-17143192155
         AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkr.krfslgkfgtaeeAakaaiaarkkleg 55 
                 s+y+GV++++++grW+++I+d      + k+++lg f+ta  Aa+a+++a+ k++g
  KHN36247.1 143 SQYRGVTFYRRTGRWESHIWD------CgKQVYLGGFDTAHAAARAYDRAAIKFRG 192
                 78*******************......55************************997 PP

2AP243.86.2e-14235285155
         AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                 s+y+GV+ +k  grW+A+   +     +k+++lg f+t+ eAa+a+++a+ k +g
  KHN36247.1 235 SKYRGVTLHK-CGRWEARMGQF--L-GKKYVYLGLFDTEIEAARAYDKAAIKCNG 285
                 89********.7******5553..2.26**********99**********99776 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541719.15E-16143201IPR016177DNA-binding domain
PfamPF008475.7E-9143192IPR001471AP2/ERF domain
CDDcd000183.11E-11144201No hitNo description
PROSITE profilePS5103217.596144200IPR001471AP2/ERF domain
SMARTSM003807.9E-32144206IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.105.4E-17144200IPR001471AP2/ERF domain
CDDcd000185.15E-25235295No hitNo description
PfamPF008471.3E-9235285IPR001471AP2/ERF domain
SuperFamilySSF541715.69E-17235295IPR016177DNA-binding domain
PROSITE profilePS5103215.461236293IPR001471AP2/ERF domain
SMARTSM003803.4E-31236299IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.102.2E-16236293IPR001471AP2/ERF domain
PRINTSPR003674.6E-6237248IPR001471AP2/ERF domain
PRINTSPR003674.6E-6275295IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010073Biological Processmeristem maintenance
GO:0010093Biological Processspecification of floral organ identity
GO:0048316Biological Processseed development
GO:0048481Biological Processplant ovule development
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 494 aa     Download sequence    Send to blast
MWDLNDSPDQ RKDYESEGCS SSLYDDKGKR VASVSNSSSS AVVVEDGSEE EDSERGGSRT  60
LDNKKTNKIF GFSVAHDDSD HPPVTHQFFP VEDSEAAAAG SSFPRAHWVG VKFCQSETPG  120
AGKAVKVSEP MKKSRRGPRS RSSQYRGVTF YRRTGRWESH IWDCGKQVYL GGFDTAHAAA  180
RAYDRAAIKF RGVEADINFN IEDYEEDLKQ MTNLTKEEFV HVLRRQSTGF PRGSSKYRGV  240
TLHKCGRWEA RMGQFLGKKY VYLGLFDTEI EAARAYDKAA IKCNGKEAVT NFDPSIYDGE  300
LNSESSGGVA ADHNLDLSLG NLISKHSNSQ SSRNHFPNSA TDQHMPPESN WQSGGSKPKL  360
VNILPKPCGR SNMEAYGQGE SETLRLLSQT HLQSPTTKEM HRYGPYRSPA EPQMPHNFAH  420
HLHQPSFHVP SSSSNRGRIG SDLSLSMSDQ QQWQQAGPPH LLATAAASSG FPQQIRPSQG  480
WLQKNGFHSL MRPS
Functional Description ? help Back to Top
Source Description
UniProtProbable transcriptional activator that promotes early floral meristem identity (PubMed:7919989). Is required subsequently for the transition of an inflorescence meristem into a floral meristem (PubMed:1675158). Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes (PubMed:1675158, PubMed:23034631). Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and SEUSS (PubMed:1675158). Directly represses AGAMOUS by recruiting the transcriptional corepressor TOPLESS and the histone deacetylase HDA19 (PubMed:23034631). It is also required during seed development (PubMed:1675158). {ECO:0000269|PubMed:1675158, ECO:0000269|PubMed:23034631, ECO:0000269|PubMed:7919989}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapKHN36247.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Negatively regulated by the C class floral homeotic protein AGAMOUS in stamens and carpels. MicroRNA 172 (miRNA172) negatively regulates APETALA2 at the translational level and may modulate its expression pattern. Seems not to be influenced by jasmonate and Alternaria brassicicola. {ECO:0000269|PubMed:12805630, ECO:0000269|PubMed:12893888, ECO:0000269|PubMed:14555699}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC1708600.0AC170860.16 Glycine max cultivar Williams 82 clone gmw1-57d24, complete sequence.
GenBankKF2208340.0KF220834.1 Glycine max cultivar Williams 82K clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208350.0KF220835.1 Glycine max cultivar Sowon clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208360.0KF220836.1 Glycine max cultivar Pureun clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208370.0KF220837.1 Glycine max cultivar Kwangkyo clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208380.0KF220838.1 Glycine max cultivar Ilpumgeomjeong clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208390.0KF220839.1 Glycine max cultivar Seoritae clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208400.0KF220840.1 Glycine max cultivar PI96983 clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208410.0KF220841.1 Glycine max cultivar Haman clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208430.0KF220843.1 Glycine max cultivar Hwangkeum clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208440.0KF220844.1 Glycine soja cultivar IT162825 clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208450.0KF220845.1 Glycine soja cultivar IT178480 clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208460.0KF220846.1 Glycine soja cultivar IT182869 clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208480.0KF220848.1 Glycine soja cultivar IT182848 clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
GenBankKF2208490.0KF220849.1 Glycine soja cultivar IT182932 clone 2f5r integrase-type DNA-binding superfamily protein (Glyma01g39520) gene, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_003517312.10.0floral homeotic protein APETALA 2 isoform X2
RefseqXP_028243790.10.0floral homeotic protein APETALA 2-like isoform X2
SwissprotP479271e-139AP2_ARATH; Floral homeotic protein APETALA 2
TrEMBLA0A445M5380.0A0A445M538_GLYSO; Floral homeotic protein APETALA 2 isoform B
TrEMBLI1J9890.0I1J989_SOYBN; Uncharacterized protein
STRINGGLYMA01G39520.30.0(Glycine max)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF37843463
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G36920.21e-132AP2 family protein
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Thamilarasan SK,Park JI,Jung HJ,Nou IS
    Genome-wide analysis of the distribution of AP2/ERF transcription factors reveals duplication and CBFs genes elucidate their potential function in Brassica oleracea.
    BMC Genomics, 2014. 15: p. 422
    [PMID:24888752]
  3. Qi X, et al.
    Identification of a novel salt tolerance gene in wild soybean by whole-genome sequencing.
    Nat Commun, 2014. 5: p. 4340
    [PMID:25004933]
  4. Zhang GB,Yi HY,Gong JM
    The Arabidopsis ethylene/jasmonic acid-NRT signaling module coordinates nitrate reallocation and the trade-off between growth and environmental adaptation.
    Plant Cell, 2014. 26(10): p. 3984-98
    [PMID:25326291]
  5. Ranocha P,Francoz E,Burlat V,Dunand C
    Expression of PRX36, PMEI6 and SBT1.7 is controlled by complex transcription factor regulatory networks for proper seed coat mucilage extrusion.
    Plant Signal Behav, 2014. 9(11): p. e977734
    [PMID:25531128]
  6. Djemal R,Khoudi H
    Isolation and molecular characterization of a novel WIN1/SHN1 ethylene-responsive transcription factor TdSHN1 from durum wheat (Triticum turgidum. L. subsp. durum).
    Protoplasma, 2015. 252(6): p. 1461-73
    [PMID:25687296]
  7. Kazan K
    Diverse roles of jasmonates and ethylene in abiotic stress tolerance.
    Trends Plant Sci., 2015. 20(4): p. 219-29
    [PMID:25731753]
  8. Prunet N, et al.
    SQUINT promotes stem cell homeostasis and floral meristem termination in Arabidopsis through APETALA2 and CLAVATA signalling.
    J. Exp. Bot., 2015. 66(21): p. 6905-16
    [PMID:26269626]
  9. Xie W, et al.
    Exploring potential new floral organ morphogenesis genes of Arabidopsis thaliana using systems biology approach.
    Front Plant Sci, 2015. 6: p. 829
    [PMID:26528302]
  10. Zumajo-Cardona C,Pabón-Mora N
    Evolution of the APETALA2 Gene Lineage in Seed Plants.
    Mol. Biol. Evol., 2016. 33(7): p. 1818-32
    [PMID:27030733]
  11. Zhao Y, et al.
    An alternative strategy for targeted gene replacement in plants using a dual-sgRNA/Cas9 design.
    Sci Rep, 2016. 6: p. 23890
    [PMID:27033976]
  12. Gao R,Liu P,Irwanto N,Loh R,Wong SM
    Upregulation of LINC-AP2 is negatively correlated with AP2 gene expression with Turnip crinkle virus infection in Arabidopsis thaliana.
    Plant Cell Rep., 2016. 35(11): p. 2257-2267
    [PMID:27473526]
  13. Huang Z, et al.
    APETALA2 antagonizes the transcriptional activity of AGAMOUS in regulating floral stem cells in Arabidopsis thaliana.
    New Phytol., 2017. 215(3): p. 1197-1209
    [PMID:27604611]
  14. Dory M, et al.
    Kinase-Associated Phosphoisoform Assay: a novel candidate-based method to detect specific kinase-substrate phosphorylation interactions in vivo.
    BMC Plant Biol., 2016. 16(1): p. 204
    [PMID:27655033]
  15. Wang P, et al.
    Expansion and Functional Divergence of AP2 Group Genes in Spermatophytes Determined by Molecular Evolution and Arabidopsis Mutant Analysis.
    Front Plant Sci, 2016. 7: p. 1383
    [PMID:27703459]
  16. Sharma P, et al.
    Promoter Trapping and Deletion Analysis Show Arabidopsis thaliana APETALA2 Gene Promoter Is Bidirectional and Functions as a Pollen- and Ovule-Specific Promoter in the Reverse Orientation.
    Appl. Biochem. Biotechnol., 2017. 182(4): p. 1591-1604
    [PMID:28130768]
  17. Kihira M, et al.
    Arabidopsis thaliana FLO2 is Involved in Efficiency of Photoassimilate Translocation, Which is Associated with Leaf Growth and Aging, Yield of Seeds and Seed Quality.
    Plant Cell Physiol., 2017. 58(3): p. 440-450
    [PMID:28158741]
  18. Balanzà V, et al.
    Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway.
    Nat Commun, 2018. 9(1): p. 565
    [PMID:29422669]
  19. Dotto M,Gómez MS,Soto MS,Casati P
    UV-B radiation delays flowering time through changes in the PRC2 complex activity and miR156 levels in Arabidopsis thaliana.
    Plant Cell Environ., 2018. 41(6): p. 1394-1406
    [PMID:29447428]
  20. Song C,Lee J,Kim T,Hong JC,Lim CO
    VOZ1, a transcriptional repressor of DREB2C, mediates heat stress responses in Arabidopsis.
    Planta, 2018. 247(6): p. 1439-1448
    [PMID:29536220]