PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KHN19070.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Phaseoleae; Glycine; Soja
Family bHLH
Protein Properties Length: 184aa    MW: 21635.7 Da    PI: 4.6105
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KHN19070.1genomeTCUHKView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH13.80.000114080455
                HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
         HLH  4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55
                ++ e ErrRR+++ s++  Lr+++           +Ka+i+e A+ YI +Lq
  KHN19070.1 40 KNLETERRRREKLSSRLLMLRSIM-----------NKAMIVEDAITYIEKLQ 80
                56689***************9987...........566************99 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000833.83E-83584No hitNo description
SuperFamilySSF474592.36E-113596IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.4E-83599IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003536.6E-54285IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 184 aa     Download sequence    Send to blast
MEYEDEDWLC VTMDEFSLAT ENGCNRKRNF DDDTKEYKSK NLETERRRRE KLSSRLLMLR  60
SIMNKAMIVE DAITYIEKLQ DKVQSLSQEL HQMEATSEET AETKIVEIDA AEDMKNWGIQ  120
EEVIVEEINE NKLWVKIIVE KKRGRFSRLM EALNNFGIEL IDTNLTTTKG AFLITSFIKV  180
ILRL
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
14449ERRRRE
24550RRRREK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Involved in the control of tapetum development. Required for male fertility and pollen differentiation, especially during callose deposition. {ECO:0000269|PubMed:16831835}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapKHN19070.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAP0150384e-50AP015038.1 Vigna angularis var. angularis DNA, chromosome 5, almost complete sequence, cultivar: Shumari.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_003541764.11e-114transcription factor DYT1
RefseqXP_028189699.11e-114transcription factor DYT1-like
SwissprotO819001e-34DYT1_ARATH; Transcription factor DYT1
TrEMBLA0A0B2QCQ21e-129A0A0B2QCQ2_GLYSO; Transcription factor DYSFUNCTIONAL TAPETUM 1
STRINGGLYMA13G32370.21e-114(Glycine max)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF55102948
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G21330.18e-23bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Jiang J,Zhang Z,Cao J
    Pollen wall development: the associated enzymes and metabolic pathways.
    Plant Biol (Stuttg), 2013. 15(2): p. 249-63
    [PMID:23252839]
  3. Qi X, et al.
    Identification of a novel salt tolerance gene in wild soybean by whole-genome sequencing.
    Nat Commun, 2014. 5: p. 4340
    [PMID:25004933]
  4. Qian H, et al.
    Trace concentrations of imazethapyr (IM) affect floral organs development and reproduction in Arabidopsis thaliana: IM-induced inhibition of key genes regulating anther and pollen biosynthesis.
    Ecotoxicology, 2015. 24(1): p. 163-71
    [PMID:25348600]
  5. Shumin Z, et al.
    One novel cis-element is essential for correct DYSFUNCTIONAL TAPETUM 1 (DYT1) expression in Arabidopsis thaliana.
    Plant Cell Rep., 2015. 34(10): p. 1773-80
    [PMID:26134855]
  6. Cui J, et al.
    Feedback Regulation of DYT1 by Interactions with Downstream bHLH Factors Promotes DYT1 Nuclear Localization and Anther Development.
    Plant Cell, 2016. 28(5): p. 1078-93
    [PMID:27113773]
  7. Arkadir D, et al.
    DYT1 dystonia increases risk taking in humans.
    Elife, 2017.
    [PMID:27249418]
  8. Premi E, et al.
    Functional Connectivity Networks in Asymptomatic and Symptomatic DYT1 Carriers.
    Mov. Disord., 2016. 31(11): p. 1739-1743
    [PMID:27453152]
  9. Beauvais G, et al.
    Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis.
    J. Neurosci., 2016. 36(40): p. 10245-10256
    [PMID:27707963]
  10. Richter F,Gerstenberger J,Bauer A,Liang CC,Richter A
    Sensorimotor tests unmask a phenotype in the DYT1 knock-in mouse model of dystonia.
    Behav. Brain Res., 2017. 317: p. 536-541
    [PMID:27769743]
  11. Zhou S, et al.
    Function Identification of the Nucleotides in Key cis-Element of DYSFUNCTIONAL TAPETUM1 (DYT1) Promoter.
    Front Plant Sci, 2017. 8: p. 153
    [PMID:28261229]
  12. Li DD,Xue JS,Zhu J,Yang ZN
    Gene Regulatory Network for Tapetum Development in Arabidopsis thaliana.
    Front Plant Sci, 2017. 8: p. 1559
    [PMID:28955355]
  13. Ponterio G, et al.
    Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia.
    Mov. Disord., 2018. 33(2): p. 310-320
    [PMID:29150865]
  14. György B, et al.
    Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts.
    Sci Rep, 2018. 8(1): p. 2324
    [PMID:29396398]