PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_D12G2590
Common NameHOX3
Organism
Gossypium hirsutum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family HD-ZIP
Protein Properties Length: 711aa    MW: 78166.6 Da    PI: 6.7556
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_D12G2590genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox65.29e-212681156
                 TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
     Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                 +++ +++t++q+++Le++F+++++p++++r +L+++lgL  rq+k+WFqNrR+++k
  Gh_D12G2590 26 KKPYHRHTAHQIQRLESMFKECPHPDEKQRLHLSRELGLAPRQIKFWFQNRRTQMK 81
                 78999************************************************998 PP
2START174.37.7e-552254462205
                  HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS........SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEEEEE CS
        START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv.......dsgealrasgvvdmvlallveellddkeqWdetla....kaetlev 84 
                  +a  a++el+++ + +ep+W ks     + +n + + ++f++ ++        ++ea+r+sgvv+m+   lv  ++d++ +W e ++     a+t+ev
  Gh_D12G2590 225 IAANAMEELLRLLQTNEPLWIKSTndgkDVLNLESYERIFPKPNNthfkspnIRVEASRDSGVVIMNGLALVDMFMDSN-KWVELFPtivsIAKTIEV 321
                  67889*******************998888888888888887777899***99**************************.******999999****** PP

                  ECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--SS CS
        START  85 issg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwvehvdlkgr 175
                  is+g      g lqlm+ elq+lsplvp R+f+++Ry++q ++g w+iv vS d +q+ ++     R+++lpSg+li++++ng+skvtw+e+v+ +++
  Gh_D12G2590 322 ISPGmlgthsGSLQLMYEELQVLSPLVPtREFYTLRYCQQIEQGLWAIVNVSYDLPQFASQ----CRSHRLPSGCLIQDMPNGYSKVTWLERVEIEDK 415
                  **********************************************************987....********************************* PP

                  XX.HHHHHHHHHHHHHHHHHHHHHHTXXXXX CS
        START 176 lp.hwllrslvksglaegaktwvatlqrqce 205
                  +p h l+r lv+sg a+ga +w+ tlqr ce
  Gh_D12G2590 416 TPiHRLYRDLVHSGSAFGAERWLTTLQRMCE 446
                  ****************************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466891.34E-201183IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.601.7E-221177IPR009057Homeodomain-like
PROSITE profilePS5007117.752383IPR001356Homeobox domain
SMARTSM003892.3E-192587IPR001356Homeobox domain
CDDcd000866.13E-192684No hitNo description
PfamPF000462.2E-182681IPR001356Homeobox domain
PROSITE patternPS0002705881IPR017970Homeobox, conserved site
PROSITE profilePS5084851.9215450IPR002913START domain
SuperFamilySSF559612.2E-38216448No hitNo description
CDDcd088752.89E-119219446No hitNo description
SMARTSM002341.3E-44224447IPR002913START domain
PfamPF018527.9E-48225446IPR002913START domain
Gene3DG3DSA:3.30.530.209.8E-8279417IPR023393START-like domain
SuperFamilySSF559613.57E-22468703No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 711 aa     Download sequence    Send to blast
MDCGSGGVGA SGSGGDHDSS DLSRRKKPYH RHTAHQIQRL ESMFKECPHP DEKQRLHLSR  60
ELGLAPRQIK FWFQNRRTQM KAQHERADNS ALRAENDKIR CENIAIREAL KNVICPSCGG  120
PPVTEDSYFD DQKMRMENAQ LKEELDRVSS IAAKYIGRPI SQLPPVQPVH ISSLDIRMAS  180
FDGYGVGAGP SLDLDLLPGS SSSMPNLPFQ PVVISDMDKS LMSDIAANAM EELLRLLQTN  240
EPLWIKSTND GKDVLNLESY ERIFPKPNNT HFKSPNIRVE ASRDSGVVIM NGLALVDMFM  300
DSNKWVELFP TIVSIAKTIE VISPGMLGTH SGSLQLMYEE LQVLSPLVPT REFYTLRYCQ  360
QIEQGLWAIV NVSYDLPQFA SQCRSHRLPS GCLIQDMPNG YSKVTWLERV EIEDKTPIHR  420
LYRDLVHSGS AFGAERWLTT LQRMCEWFAC LRVSSTSTRD LGGVIPSPEG RRSMMKLAQR  480
MVNNFCTSVG TSNSHRSTTL SGSNEIGVRV TVHKSSDPGQ PNGIVLSAAT TFWLPVSPQN  540
VFNFFKDERT RPQWDVLSSG NAVQEVAHIA NGSHPGNCIS VLRAFNTSHN NMLILQESCI  600
DSSGSLVVYC PVDLPAINVA MSGEDPSYIP LLPSGFTITP DGHLEQGDGA STSSSTGHGR  660
SSGGSLITVA FQILVSSLPS AKLNLDSVTT VNNLIGTTVQ QIKAALNGPS S
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Ghi.164600.0boll| ovule
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO518722860.0
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: During embryo development, expressed in all cells at the 4- and 16-cell embryo stages. Expression is restricted to the protoderm from the globular stage onward. {ECO:0000269|PubMed:25564655}.
UniprotTISSUE SPECIFICITY: Expressed in apical meristems and young epidermal tissue including trichomes and stipules. Expressed in lateral root tips, the L1 layer of apical inflorescence meristems and early flower primordia, carpel and petal epidermis, stigma papillae, ovule primordia, nucellus and embryo. {ECO:0000269|PubMed:16778018}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKJ5958480.0KJ595848.1 Gossypium hirsutum homeodomain protein HOX3-D (HOX3) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001313868.10.0homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A060A4X50.0A0A060A4X5_GOSHI; Homeodomain protein HOX3-D
STRINGGorai.008G293300.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM30042665
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]