PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Gh_D05G1981

Organism

Gossypium hirsutum

Taxonomic ID

3635

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium

Family

MYB

Protein Properties

Length: 264aa MW: 28529.1 Da PI: 8.3453

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Gh_D05G1981	genome	NAU-NBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	54.3	3.1e-17	31	76	1	47
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqky 47 +g+W++ Ede l ++v+ +G+++W++I++ ++ gR++k+c++rw + Gh_D05G1981 31 KGPWSPGEDEALQRLVHTYGPKNWSLISKSIP-GRSGKSCRLRWCNQ 76 79****************************.*********985 PP
2	Myb_DNA-binding	36.2	1.4e-11	85	117	3	37
SS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-H CS Myb_DNA-binding 3 rWTteEdellvdavkqlGggtWktIartmgkgRtl 37 ++T+eEd+ +++a++q+G++ W+ Iar ++ gRt+ Gh_D05G1981 85 PFTPEEDDTIIQAHAQFGNK-WAIIARLLN-GRTP 117 89****************.*****.*7 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	23.917	26	81	IPR017930	Myb domain
SuperFamily	SSF46689	6.74E-28	28	118	IPR009057	Homeodomain-like
SMART	SM00717	9.5E-16	30	79	IPR001005	SANT/Myb domain
Pfam	PF00249	3.1E-17	31	76	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	1.8E-25	32	90	IPR009057	Homeodomain-like
CDD	cd00167	1.84E-15	33	75	No hit	No description
PROSITE profile	PS51294	9.767	82	126	IPR017930	Myb domain
SMART	SM00717	0.017	82	121	IPR001005	SANT/Myb domain
Pfam	PF00249	1.1E-9	85	117	IPR001005	SANT/Myb domain
CDD	cd00167	1.05E-7	85	117	No hit	No description
Gene3D	G3DSA:1.10.10.60	1.3E-12	91	117	IPR009057	Homeodomain-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 264 aa Download sequence Send to blast
MPGHNSQVTT TTSTSHTSPL PIYVKDLDRI KGPWSPGEDE ALQRLVHTYG PKNWSLISKS 60 IPGRSGKSCR LRWCNQLSPE VQHRPFTPEE DDTIIQAHAQ FGNKWAIIAR LLNGRTPIKR 120 SASLGAANNV SGPCLNLGTP SGSDLSDSSL PAASPGYRPL ARTGSSKHVE TASSTTNPPT 180 ILSLSLPGFD PCENSDSGPR SDPIPSPTQV PVTTVTGHPT AGLVVGMQNG ELGMEKQFFS 240 NEFLTVIQEM IKTEVRNYMF GKFH

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1gv2_A	3e-29	30	116	3	89	MYB PROTO-ONCOGENE PROTEIN
1h88_C	1e-28	30	116	6	143	MYB PROTO-ONCOGENE PROTEIN
1h89_C	1e-28	30	116	6	143	MYB PROTO-ONCOGENE PROTEIN
1mse_C	3e-29	30	116	3	89	C-Myb DNA-Binding Domain
1msf_C	3e-29	30	116	3	89	C-Myb DNA-Binding Domain
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Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed during very late stages of embryogenesis. Later, its expression follows a development dependent gradient in successive leaves. {ECO:0000269\|PubMed:9678577}.
Uniprot	TISSUE SPECIFICITY: Expressed in roots, stems, leaves, inflorescence, and flowers (including stamen, floral nectar, carpel, petal and sepal), mostly in vasculatures and stomata. {ECO:0000269\|PubMed:18162593, ECO:0000269\|PubMed:9678577}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor (PubMed:23067202, PubMed:23603962). Represses the expression of protein phosphatases 2C in response to abscisic acid (ABA). Confers resistance to abiotic stresses dependent of ABA (PubMed:18162593, PubMed:9678577). In response to auxin, activates the transcription of the auxin-responsive gene IAA19. The IAA19 transcription activation by MYB44 is enhanced by direct interaction between MYB44 and PYL8 (PubMed:24894996). Transcriptional activator of WRKY70 by direct binding to its promoter region, especially at 5'-TAACNG-3' and 5'-CNGTTA-3' symmetric motifs (PubMed:23067202, PubMed:23603962). Activates salicylic acid (SA)- mediated defenses and subsequent resistance to biotrophic pathogen P.syringae pv. tomato DC3000, but represses jasmonic acid (JA)-mediated defenses responses against the necrotrophic pathogen A.brassicicola (PubMed:23067202). {ECO:0000269\|PubMed:18162593, ECO:0000269\|PubMed:23067202, ECO:0000269\|PubMed:23603962, ECO:0000269\|PubMed:24894996, ECO:0000269\|PubMed:9678577}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By drought, cold, high salinity, cadmium (CdCl(2)), salicylic acid (SA), jasmonate (JA), ethylene, gibberellic acid (GA), and ABA (PubMed:16463103, PubMed:18162593, PubMed:23067202). The induction by JA is COI1-dependent (PubMed:23067202). {ECO:0000269\|PubMed:16463103, ECO:0000269\|PubMed:18162593, ECO:0000269\|PubMed:23067202}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_012446268.1	1e-164	PREDICTED: transcription factor MYB44-like
Swissprot	Q9FDW1	4e-67	MYB44_ARATH; Transcription factor MYB44
TrEMBL	A0A0D2URN5	1e-173	A0A0D2URN5_GOSRA; Uncharacterized protein
STRING	Gorai.009G215900.1	1e-174	(Gossypium raimondii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM677	28	135

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G67300.1	3e-61	myb domain protein r1

Publications ? help Back to Top
Li C,Chang PP,Ghebremariam KM,Qin L,Liang Y Overexpression of tomato SpMPK3 gene in Arabidopsis enhances the osmotic tolerance. Biochem. Biophys. Res. Commun., 2014. 443(2): p. 357-62 [PMID:24275141] Jaradat MR,Feurtado JA,Huang D,Lu Y,Cutler AJ Multiple roles of the transcription factor AtMYBR1/AtMYB44 in ABA signaling, stress responses, and leaf senescence. BMC Plant Biol., 2013. 13: p. 192 [PMID:24286353] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Li D, et al. Arabidopsis ABA receptor RCAR1/PYL9 interacts with an R2R3-type MYB transcription factor, AtMYB44. Int J Mol Sci, 2014. 15(5): p. 8473-90 [PMID:24828206] Xu DB, et al. A G-protein β subunit, AGB1, negatively regulates the ABA response and drought tolerance by down-regulating AtMPK6-related pathway in Arabidopsis. PLoS ONE, 2015. 10(1): p. e0116385 [PMID:25635681] Hieno A, et al. Possible Involvement of MYB44-Mediated Stomatal Regulation in Systemic Resistance Induced by Penicillium simplicissimum GP17-2 in Arabidopsis. Microbes Environ., 2016. 31(2): p. 154-9 [PMID:27301421] Zhao Q, et al. AtMYB44 Positively Regulates the Enhanced Elongation of Primary Roots Induced by N-3-Oxo-Hexanoyl-Homoserine Lactone in Arabidopsis thaliana. Mol. Plant Microbe Interact., 2016. 29(10): p. 774-785 [PMID:27604593] Song L, et al. A transcription factor hierarchy defines an environmental stress response network. Science, 2017. [PMID:27811239] Nguyen NH,Cheong JJ H2A.Z-containing nucleosomes are evicted to activate AtMYB44 transcription in response to salt stress. Biochem. Biophys. Res. Commun., 2018. 499(4): p. 1039-1043 [PMID:29649476] Nguyen NH,Cheong JJ AtMYB44 interacts with TOPLESS-RELATED corepressors to suppress protein phosphatase 2C gene transcription. Biochem. Biophys. Res. Commun., 2018. 507(1-4): p. 437-442 [PMID:30448055]