PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_D05G0105
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family bZIP
Protein Properties Length: 345aa    MW: 39453.1 Da    PI: 7.7052
Description bZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_D05G0105genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1bZIP_127.75.9e-09747444
                 XCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       bZIP_1  4 lkrerrkqkNReAArrsRqRKkaeieeLeekvkeLeaeNka 44
                  k  rr+++NReAAr+sR+R ka++++Le     L++  ++
  Gh_D05G0105  7 QKTLRRLAQNREAARKSRLRTKAYVQQLESSRLRLTELEQE 47
                 6889*************************876666665554 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.20.5.1701.1E-6251No hitNo description
SMARTSM003382.6E-7475IPR004827Basic-leucine zipper domain
PfamPF077161.6E-7554IPR004827Basic-leucine zipper domain
PROSITE profilePS502178.91650IPR004827Basic-leucine zipper domain
CDDcd147086.50E-22860No hitNo description
SuperFamilySSF579593.69E-6851No hitNo description
PROSITE patternPS0003601126IPR004827Basic-leucine zipper domain
SuperFamilySSF512068.08E-24122240IPR018490Cyclic nucleotide-binding-like
Gene3DG3DSA:1.10.287.6301.4E-7122180No hitNo description
Gene3DG3DSA:2.60.120.101.8E-8181240IPR014710RmlC-like jelly roll fold
CDDcd000382.15E-7194240No hitNo description
PROSITE profilePS5004210.506194240IPR000595Cyclic nucleotide-binding domain
SMARTSM002482200265294IPR002110Ankyrin repeat
SuperFamilySSF484034.35E-20270344IPR020683Ankyrin repeat-containing domain
PfamPF127961.4E-11272344IPR020683Ankyrin repeat-containing domain
Gene3DG3DSA:1.25.40.206.4E-19273344IPR020683Ankyrin repeat-containing domain
CDDcd002042.35E-20273344No hitNo description
PROSITE profilePS5029722.888273345IPR020683Ankyrin repeat-containing domain
SMARTSM002481.0E-5298327IPR002110Ankyrin repeat
PROSITE profilePS5008813.865298330IPR002110Ankyrin repeat
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 345 aa     Download sequence    Send to blast
MSKSSDQKTL RRLAQNREAA RKSRLRTKAY VQQLESSRLR LTELEQELQR AQQQGIFIAS  60
GLSGDHGHTV AGNAALAFDM EYEDIHAVNM REMIFIMIYV SFDMILGAYL ISNMTALIVK  120
GSKTEKFRDK MADIIKYMNR NKLERDLRNQ IKGHLRLQYE STYTEAAVLQ DIPISIRAKI  180
SQSLYLPYIE NASLFKECSS EFINQIIIRL HEEFFLPGEA IMEQGNVVDQ LYFVCHGVLE  240
GKESNLRVRQ LELDISFHIR RQEAELALRM NGAAYNGDFY QLKSLIRAGA DPNKTDCDGR  300
SPLHLAASKG YEDITSFLIR HPVDINLKDK FGNTPLLESI KNGHD
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5kba_A2e-162643451394Designed protein ANK1C2
5kba_B2e-162643451394Designed protein ANK1C2
5kba_C2e-162643451394Designed protein ANK1C2
5kba_D2e-162643451394Designed protein ANK1C2
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Ghi.252551e-102boll| ovule
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in guard cell-containing tissues, in root epidermal cells and in root hairs. Detected in vascular cells of the root and shoot. {ECO:0000269|PubMed:11113445, ECO:0000269|PubMed:11728473}.
Functional Description ? help Back to Top
Source Description
UniProtMajor selective outward-rectifying potassium channel of the guard cell membrane. Involved in regulation of stomatal movements according to the water status. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by depolarization. Conductance of the channel is modulated in a potassium-dependent fashion. May interact with the cytoskeleton or with regulatory proteins. {ECO:0000269|PubMed:12671068}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated under drought, salt stress and cold conditions. Induced by abscisic acid (ABA) treatment in roots and shoots but not in guard cells. {ECO:0000269|PubMed:14596925}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015389400.11e-157potassium channel SKOR-like isoform X3
SwissprotQ94A761e-116GORK_ARATH; Potassium channel GORK
TrEMBLA0A2P5QIM50.0A0A2P5QIM5_GOSBA; Uncharacterized protein
STRINGXP_010108959.11e-133(Morus notabilis)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G06960.29e-19OCS-element binding factor 5
Publications ? help Back to Top
  1. Ache P, et al.
    GORK, a delayed outward rectifier expressed in guard cells of Arabidopsis thaliana, is a K(+)-selective, K(+)-sensing ion channel.
    FEBS Lett., 2000. 486(2): p. 93-8
    [PMID:11113445]
  2. Mäser P, et al.
    Phylogenetic relationships within cation transporter families of Arabidopsis.
    Plant Physiol., 2001. 126(4): p. 1646-67
    [PMID:11500563]
  3. Ivashikina N, et al.
    K(+) channel profile and electrical properties of Arabidopsis root hairs.
    FEBS Lett., 2001. 508(3): p. 463-9
    [PMID:11728473]
  4. Moshelion M, et al.
    Diurnal and circadian regulation of putative potassium channels in a leaf moving organ.
    Plant Physiol., 2002. 128(2): p. 634-42
    [PMID:11842166]
  5. Reintanz B, et al.
    AtKC1, a silent Arabidopsis potassium channel alpha -subunit modulates root hair K+ influx.
    Proc. Natl. Acad. Sci. U.S.A., 2002. 99(6): p. 4079-84
    [PMID:11904452]
  6. Hosy E, et al.
    The Arabidopsis outward K+ channel GORK is involved in regulation of stomatal movements and plant transpiration.
    Proc. Natl. Acad. Sci. U.S.A., 2003. 100(9): p. 5549-54
    [PMID:12671068]
  7. Deeken R, et al.
    Tumour development in Arabidopsis thaliana involves the Shaker-like K+ channels AKT1 and AKT2/3.
    Plant J., 2003. 34(6): p. 778-87
    [PMID:12795698]
  8. Becker D, et al.
    Regulation of the ABA-sensitive Arabidopsis potassium channel gene GORK in response to water stress.
    FEBS Lett., 2003. 554(1-2): p. 119-26
    [PMID:14596925]
  9. Suhita D,Raghavendra AS,Kwak JM,Vavasseur A
    Cytoplasmic alkalization precedes reactive oxygen species production during methyl jasmonate- and abscisic acid-induced stomatal closure.
    Plant Physiol., 2004. 134(4): p. 1536-45
    [PMID:15064385]
  10. Wienkoop S, et al.
    Cell-specific protein profiling in Arabidopsis thaliana trichomes: identification of trichome-located proteins involved in sulfur metabolism and detoxification.
    Phytochemistry, 2004. 65(11): p. 1641-9
    [PMID:15276459]
  11. Dreyer I, et al.
    Assembly of plant Shaker-like K(out) channels requires two distinct sites of the channel alpha-subunit.
    Biophys. J., 2004. 87(2): p. 858-72
    [PMID:15298894]
  12. Sirichandra C,Wasilewska A,Vlad F,Valon C,Leung J
    The guard cell as a single-cell model towards understanding drought tolerance and abscisic acid action.
    J. Exp. Bot., 2009. 60(5): p. 1439-63
    [PMID:19181866]
  13. Demidchik V, et al.
    Arabidopsis root K+-efflux conductance activated by hydroxyl radicals: single-channel properties, genetic basis and involvement in stress-induced cell death.
    J. Cell. Sci., 2010. 123(Pt 9): p. 1468-79
    [PMID:20375061]
  14. Meyer S, et al.
    AtALMT12 represents an R-type anion channel required for stomatal movement in Arabidopsis guard cells.
    Plant J., 2010. 63(6): p. 1054-62
    [PMID:20626656]
  15. Jeanguenin L, et al.
    AtKC1 is a general modulator of Arabidopsis inward Shaker channel activity.
    Plant J., 2011. 67(4): p. 570-82
    [PMID:21518051]
  16. Tran D, et al.
    Post-transcriptional regulation of GORK channels by superoxide anion contributes to increases in outward-rectifying K⁺ currents.
    New Phytol., 2013. 198(4): p. 1039-48
    [PMID:23517047]
  17. Jayakannan M,Bose J,Babourina O,Rengel Z,Shabala S
    Salicylic acid improves salinity tolerance in Arabidopsis by restoring membrane potential and preventing salt-induced K+ loss via a GORK channel.
    J. Exp. Bot., 2013. 64(8): p. 2255-68
    [PMID:23580750]
  18. Eisenach C,Papanatsiou M,Hillert EK,Blatt MR
    Clustering of the K+ channel GORK of Arabidopsis parallels its gating by extracellular K+.
    Plant J., 2014. 78(2): p. 203-14
    [PMID:24517091]
  19. Demidchik V
    Mechanisms and physiological roles of K+ efflux from root cells.
    J. Plant Physiol., 2014. 171(9): p. 696-707
    [PMID:24685330]
  20. Xie Y, et al.
    Reactive Oxygen Species-Dependent Nitric Oxide Production Contributes to Hydrogen-Promoted Stomatal Closure in Arabidopsis.
    Plant Physiol., 2014. 165(2): p. 759-773
    [PMID:24733882]
  21. Planes MD, et al.
    A mechanism of growth inhibition by abscisic acid in germinating seeds of Arabidopsis thaliana based on inhibition of plasma membrane H+-ATPase and decreased cytosolic pH, K+, and anions.
    J. Exp. Bot., 2015. 66(3): p. 813-25
    [PMID:25371509]
  22. Lefoulon C, et al.
    The Arabidopsis AtPP2CA Protein Phosphatase Inhibits the GORK K+ Efflux Channel and Exerts a Dominant Suppressive Effect on Phosphomimetic-activating Mutations.
    J. Biol. Chem., 2016. 291(12): p. 6521-33
    [PMID:26801610]
  23. Li J, et al.
    Functional identification of a GORK potassium channel from the ancient desert shrub Ammopiptanthus mongolicus (Maxim.) Cheng f.
    Plant Cell Rep., 2016. 35(4): p. 803-15
    [PMID:26804987]
  24. Shi WL, et al.
    Cellular and molecular insight into the inhibition of primary root growth of Arabidopsis induced by peptaibols, a class of linear peptide antibiotics mainly produced by Trichoderma spp.
    J. Exp. Bot., 2016. 67(8): p. 2191-205
    [PMID:26850879]
  25. Wang F, et al.
    Revealing the roles of GORK channels and NADPH oxidase in acclimation to hypoxia in Arabidopsis.
    J. Exp. Bot., 2017. 68(12): p. 3191-3204
    [PMID:28338729]
  26. Corratgé-Faillie C, et al.
    The Arabidopsis guard cell outward potassium channel GORK is regulated by CPK33.
    FEBS Lett., 2017. 591(13): p. 1982-1992
    [PMID:28543075]
  27. Rajarammohan S,Pradhan AK,Pental D,Kaur J
    Genome-wide association mapping in Arabidopsis identifies novel genes underlying quantitative disease resistance to Alternaria brassicae.
    Mol. Plant Pathol., 2018. 19(7): p. 1719-1732
    [PMID:29271603]
  28. Isner JC,Begum A,Nuehse T,Hetherington AM,Maathuis FJM
    KIN7 Kinase Regulates the Vacuolar TPK1 K+ Channel during Stomatal Closure.
    Curr. Biol., 2018. 28(3): p. 466-472.e4
    [PMID:29395926]
  29. van Kleeff PJM, et al.
    The Arabidopsis GORK K+-channel is phosphorylated by calcium-dependent protein kinase 21 (CPK21), which in turn is activated by 14-3-3 proteins.
    Plant Physiol. Biochem., 2018. 125: p. 219-231
    [PMID:29475088]
  30. Cuin TA,Dreyer I,Michard E
    The Role of Potassium Channels in Arabidopsis thaliana Long Distance Electrical Signalling: AKT2 Modulates Tissue Excitability While GORK Shapes Action Potentials.
    Int J Mol Sci, 2018.
    [PMID:29561764]