PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_A12G0259
Organism
Gossypium hirsutum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family bHLH
Protein Properties Length: 448aa    MW: 49668.2 Da    PI: 6.3587
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_A12G0259genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH30.66e-10227274455
                  HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
          HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                  +h+ +Er RR++i +++  L++l+P +    +k   Ka +L + ++Y++sLq
  Gh_A12G0259 227 SHSLAERVRREKISERMKYLQDLVPGC----NKITGKAGMLDEIINYVQSLQ 274
                  8**************************....999*****************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF474593.4E-15221280IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000833.38E-10221278No hitNo description
Gene3DG3DSA:4.10.280.101.1E-15221278IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.618223273IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.4E-7227274IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.9E-9229279IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 448 aa     Download sequence    Send to blast
MNRALAETLT VLDRQRARVK WQQESYFSEL SGVFSNQTST HVHGFQGDLI SDESVLDDLV  60
MTRQVKPDPH LETSWPELGK VDMAGMGFGP CGYSNGPSFD MNYAISRTFS CPPAVAATIA  120
KEATEVKGKE SIVSENMGSA VARESSKKRK ADKLHNLKVA ADDDSKKTKA CGEEGEESKI  180
TRPPNTNKSS TKQEPSADTS KENSKLTEVQ KPDYIHVRAR RSQATDSHSL AERVRREKIS  240
ERMKYLQDLV PGCNKITGKA GMLDEIINYV QSLQRQVEVK TFTIFIFFIY FVSSSVLIVH  300
NLQFLSMKLA AVNPRLDFDI DNLFAKDVFP PCITNFPTVG ISSEMANPSY LHFNPVQQVV  360
ACSGVEMGLN SPDIALRRTI SAPESTILDA SFLDTSCFTQ IQPSPTWDVE LQNVYNVAFE  420
HGRSTTPFPS QPFAAAGSIE ASHLKMEM
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed constitutively in roots, leaves, and stems. {ECO:0000269|PubMed:12679534}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that binds DNA to G box 5'-CACGTG-3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light. {ECO:0000269|PubMed:18988809, ECO:0000269|PubMed:24130508}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Accumulates strongly in response to blue light due to reduced preventing 26S proteasome-mediated degradation in an ADO1/ZTL and ADO2/LKP2 dependent manner, but levels decrease in the absence of blue light via 26S proteasome degradation (at protein level). {ECO:0000269|PubMed:24101505}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017635198.10.0PREDICTED: transcription factor HBI1-like isoform X1
SwissprotQ8GY613e-59BH063_ARATH; Transcription factor bHLH63
TrEMBLA0A0B0MUS10.0A0A0B0MUS1_GOSAR; Transcription factor bHLH63-like protein
STRINGGorai.008G029300.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM59472543
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G34530.11e-61cryptochrome-interacting basic-helix-loop-helix 1
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Yang D,Zhao W,Meng Y,Li H,Liu B
    A CIB1-LIKE transcription factor GmCIL10 from soybean positively regulates plant flowering.
    Sci China Life Sci, 2015. 58(3): p. 261-9
    [PMID:25651969]
  3. Katsura Y, et al.
    An optogenetic system for interrogating the temporal dynamics of Akt.
    Sci Rep, 2015. 5: p. 14589
    [PMID:26423353]
  4. Taslimi A, et al.
    Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase.
    Nat. Chem. Biol., 2016. 12(6): p. 425-30
    [PMID:27065233]
  5. Liu Q, et al.
    The Blue Light-Dependent Polyubiquitination and Degradation of Arabidopsis Cryptochrome2 Requires Multiple E3 Ubiquitin Ligases.
    Plant Cell Physiol., 2016. 57(10): p. 2175-2186
    [PMID:27516416]
  6. Pathak GP, et al.
    Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2.
    Nucleic Acids Res., 2017. 45(20): p. e167
    [PMID:28431041]
  7. Duan L, et al.
    Understanding CRY2 interactions for optical control of intracellular signaling.
    Nat Commun, 2017. 8(1): p. 547
    [PMID:28916751]
  8. Quejada JR, et al.
    Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1.
    Nucleic Acids Res., 2017. 45(20): p. e172
    [PMID:29040770]
  9. Liu Y, et al.
    CIB1 and CO interact to mediate CRY2-dependent regulation of flowering.
    EMBO Rep., 2019.
    [PMID:30126927]