PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_A10G2221
Organism
Gossypium hirsutum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family MIKC_MADS
Protein Properties Length: 246aa    MW: 28368.1 Da    PI: 9.6487
Description MIKC_MADS family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_A10G2221genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1SRF-TF98.92e-312473150
                 S---SHHHHHHHHHHHHHHHHHHHHHHHHHHT-EEEEEEE-TTSEEEEEE CS
       SRF-TF  1 krienksnrqvtfskRrngilKKAeELSvLCdaevaviifsstgklyeys 50
                 krien++nrqvtf+kRrng+lKKA+ELSvLCdaeva+i+fs++g+lyey+
  Gh_A10G2221 24 KRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALIVFSNRGRLYEYA 73
                 79***********************************************8 PP
2K-box115.54.9e-38911874100
        K-box   4 ssgksleeakaeslqqelakLkkeienLqreqRhllGedLesLslkeLqqLeqqLekslkkiRskKnellleqieelqkkekelqeenkaLrkklee 100
                  s++ s++e +a+ +qqe++kL+++i+nLq+++Rh+lGe+++ L +keL++Le++Lek++++iRskKnell+++ie++qkke +l+++n+ Lr+k++e
  Gh_A10G2221  91 SNTGSVAEVNAQFYQQEADKLRNQIRNLQNTNRHMLGESVGGLPMKELKSLETRLEKGISRIRSKKNELLFAEIEYMQKKEIDLHNNNQLLRAKIAE 187
                  3344499***************************************************************************************986 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM004322.3E-421675IPR002100Transcription factor, MADS-box
PROSITE profilePS5006634.0761676IPR002100Transcription factor, MADS-box
CDDcd002656.89E-461791No hitNo description
SuperFamilySSF554554.45E-3417105IPR002100Transcription factor, MADS-box
PRINTSPR004046.1E-331838IPR002100Transcription factor, MADS-box
PROSITE patternPS0035001872IPR002100Transcription factor, MADS-box
PfamPF003191.2E-262572IPR002100Transcription factor, MADS-box
PRINTSPR004046.1E-333853IPR002100Transcription factor, MADS-box
PRINTSPR004046.1E-335374IPR002100Transcription factor, MADS-box
PfamPF014863.2E-28100185IPR002487Transcription factor, K-box
PROSITE profilePS5129715.144101191IPR002487Transcription factor, K-box
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009414Biological Processresponse to water deprivation
GO:0090376Biological Processseed trichome differentiation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 246 aa     Download sequence    Send to blast
MVYPNESLED SPQKKMGRGK IEIKRIENTT NRQVTFCKRR NGLLKKAYEL SVLCDAEVAL  60
IVFSNRGRLY EYANNSVKAT IERYKKASDS SNTGSVAEVN AQFYQQEADK LRNQIRNLQN  120
TNRHMLGESV GGLPMKELKS LETRLEKGIS RIRSKKNELL FAEIEYMQKK EIDLHNNNQL  180
LRAKIAENER KQESMNLMPG GSSNNFEAIH SQPYDSRNYF QVDALQPAAN YYNPQQQQDQ  240
IVLQLV
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1tqe_P4e-211689174Myocyte-specific enhancer factor 2B
1tqe_Q4e-211689174Myocyte-specific enhancer factor 2B
1tqe_R4e-211689174Myocyte-specific enhancer factor 2B
1tqe_S4e-211689174Myocyte-specific enhancer factor 2B
6c9l_A4e-211689174Myocyte-specific enhancer factor 2B
6c9l_B4e-211689174Myocyte-specific enhancer factor 2B
6c9l_C4e-211689174Myocyte-specific enhancer factor 2B
6c9l_D4e-211689174Myocyte-specific enhancer factor 2B
6c9l_E4e-211689174Myocyte-specific enhancer factor 2B
6c9l_F4e-211689174Myocyte-specific enhancer factor 2B
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Ghi.169040.0boll| ovule
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Detected early in the floral meristem but mostly expressed in stamen and carpel primordia. {ECO:0000269|PubMed:1675158}.
UniprotTISSUE SPECIFICITY: Flower. Preferentially expressed in stamen and carpel and weakly in petal. Undetected in leaves and roots.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor involved in regulating genes that determines stamen and carpel development in wild-type flowers. {ECO:0000250}.
UniProtProbable transcription factor involved in the control of organ identity during the early development of flowers. Is required for normal development of stamens and carpels in the wild-type flower. Plays a role in maintaining the determinacy of the floral meristem. Acts as C class cadastral protein by repressing the A class floral homeotic genes like APETALA1. Forms a heterodimer via the K-box domain with either SEPALATTA1/AGL2, SEPALATTA2/AGL4, SEPALLATA3/AGL9 or AGL6 that could be involved in genes regulation during floral meristem development. Controls AHL21/GIK, a multifunctional chromatin modifier in reproductive organ patterning and differentiation (PubMed:19956801). Induces microsporogenesis through the activation of SPL/NZZ (PubMed:15254538). {ECO:0000269|PubMed:15254538, ECO:0000269|PubMed:19956801}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Negatively regulated by the A class floral homeotic protein APETALA2 and by other repressors like LEUNIG, SEUSS, SAP or CURLY LEAF. Positively regulated by both LEAFY and APETALA1. Repressed by silencing mediated by polycomb group (PcG) protein complex containing EMF1 and EMF2. Up-regulated by HUA2. {ECO:0000269|PubMed:10198637, ECO:0000269|PubMed:11058164, ECO:0000269|PubMed:1675158, ECO:0000269|PubMed:17794879, ECO:0000269|PubMed:18281509, ECO:0000269|PubMed:19783648, ECO:0000269|PubMed:9783581}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankEF1905470.0EF190547.1 Gossypium hirsutum MADS-box protein MADS4 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001314176.10.0floral homeotic protein AGAMOUS-like
RefseqXP_016711292.10.0PREDICTED: floral homeotic protein AGAMOUS-like isoform X3
RefseqXP_016711293.10.0PREDICTED: floral homeotic protein AGAMOUS-like isoform X3
RefseqXP_017646544.10.0PREDICTED: floral homeotic protein AGAMOUS-like isoform X5
RefseqXP_017646545.10.0PREDICTED: floral homeotic protein AGAMOUS-like isoform X5
SwissprotP178391e-123AG_ARATH; Floral homeotic protein AGAMOUS
SwissprotQ408721e-123AG_PANGI; Floral homeotic protein AGAMOUS
TrEMBLA2IBU90.0A2IBU9_GOSHI; MADS-box protein MADS4
STRINGGorai.011G035500.11e-178(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM61812237
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G18960.11e-121MIKC_MADS family protein
Publications ? help Back to Top
  1. Lightfoot DJ,Malone KM,Timmis JN,Orford SJ
    Evidence for alternative splicing of MADS-box transcripts in developing cotton fibre cells.
    Mol. Genet. Genomics, 2008. 279(1): p. 75-85
    [PMID:17943315]
  2. Huang Z, et al.
    APETALA2 antagonizes the transcriptional activity of AGAMOUS in regulating floral stem cells in Arabidopsis thaliana.
    New Phytol., 2017. 215(3): p. 1197-1209
    [PMID:27604611]
  3. Rong XF, et al.
    Type-B ARRs Control Carpel Regeneration Through Mediating AGAMOUS Expression in Arabidopsis.
    Plant Cell Physiol., 2018. 59(4): p. 756-764
    [PMID:29186581]
  4. Uemura A, et al.
    Regulation of floral meristem activity through the interaction of AGAMOUS, SUPERMAN, and CLAVATA3 in Arabidopsis.
    Plant Reprod, 2018. 31(1): p. 89-105
    [PMID:29218596]