PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_A09G0927
Organism
Gossypium hirsutum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family E2F/DP
Protein Properties Length: 492aa    MW: 54729.2 Da    PI: 4.4342
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_A09G0927genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP66.82.8e-21153236771
      E2F_TDP   7 rlltqkflkllekseegivtlnevakeLvse.......................dvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  +llt+kf++l++++e+gi++ln++a++L  e                       +v  ++RRiYDi+NVLe+++l ekk kn+i+wkg
  Gh_A09G0927 153 GLLTRKFINLIKQAEDGILDLNKAADTL--EvtvsllgqtiqsynpilngflflQV--QKRRIYDITNVLEGIGLREKKLKNRIQWKG 236
                  589*************************..668*******************9888..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM013722.8E-19147236IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.45E-10153237IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.104.3E-21153238IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023198.6E-18153236IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.50E-48247353No hitNo description
SuperFamilySSF1440741.83E-34248353No hitNo description
PfamPF164212.8E-34252351IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 492 aa     Download sequence    Send to blast
MSASQEPLNQ PLRLQNQQLP FSMKPPFMSP GGDYHHFAST ESRRLADQKG DAIVVQSPRK  60
SDVADREVES GDWARPPGYT EVIGSPLQTP VSGKGGKAQK ASRLTKNSRS GPQIPASNLG  120
SPGNNVTPTG PCRYDSSLVN SKTDIMFSEF NPGLLTRKFI NLIKQAEDGI LDLNKAADTL  180
EVTVSLLGQT IQSYNPILNG FLFLQVQKRR IYDITNVLEG IGLREKKLKN RIQWKGLDVS  240
RPGEIDENVT TLQAEVENLS IEERCLDEQI REMQERLRNL SEDENNQKWL FVTEEDIKSL  300
SCFQNETLIA IKAPHGTTLE VPDPDEAVDY SQRRYRIVLR SSMGPIDVYL VSQFEEKFEE  360
IQGADPPPNF PSTSGLNENP ATTMVPEESR GKEIEMQWQD DNKMCSDLNA SQDFVSGIMK  420
IVPSDVDCDA DYWLLSDPSI SIIDMWRTES LIEWSELGTL NEGYGMATVS STCPQTPTSN  480
ATEAPSANST GK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5tuv_B2e-192443535111Transcription factor E2F5
5tuv_E2e-192443535111Transcription factor E2F5
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant at the G1/S transition. Lower but constant level in the following phases. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:16514015}.
UniprotTISSUE SPECIFICITY: Expressed in proliferating cells and several differentiated tissues. Detected in inflorescence and shoot apical meristems, cotyledonary vascular tissues, leaf primordia, young leaves, base of trichomes, central cylinder and elongation zone of roots, lateral root primordia, flowers, pistils of immature flowers and pollen grains. {ECO:0000269|PubMed:16514015}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016669043.10.0PREDICTED: transcription factor E2FB-like
SwissprotQ9FV711e-152E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A1U8HYL50.0A0A1U8HYL5_GOSHI; transcription factor E2FB-like
STRINGGorai.006G114300.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-155E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]