PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Gh_A07G0115

Organism

Gossypium hirsutum

Taxonomic ID

3635

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium

Family

HSF

Protein Properties

Length: 344aa MW: 39907 Da PI: 6.2578

Description

HSF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Gh_A07G0115	genome	NAU-NBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HSF_DNA-bind	112.4	3e-35	84	175	2	102
HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXXXXXX CS HSF_DNA-bind 2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkellekik 98 Fl+k++e++ed++++ ++sws+ nsfvv+d +++++++LpkyFkh+nf+SFvRQLn+YgF+k+++++ weF+++ F+ g+k+ll++ik Gh_A07G0115 84 FLRKTFEMVEDPKTDPIVSWSSGRNSFVVWDCHRLSENLLPKYFKHKNFSSFVRQLNTYGFRKIDSDR---------WEFANEGFQGGRKHLLKNIK 171 9**************************************************************999.........****************** PP XXXX CS HSF_DNA-bind 99 rkks 102 r+++ Gh_A07G0115 172 RRSR 175 *986 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00415	4.8E-56	80	173	IPR000232	Heat shock factor (HSF)-type, DNA-binding
Gene3D	G3DSA:1.10.10.10	2.9E-37	80	173	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.86E-33	80	173	IPR011991	Winged helix-turn-helix DNA-binding domain
PRINTS	PR00056	1.7E-18	84	107	IPR000232	Heat shock factor (HSF)-type, DNA-binding
Pfam	PF00447	6.5E-31	84	173	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	1.7E-18	122	134	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PROSITE pattern	PS00434	0	123	147	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	1.7E-18	135	147	IPR000232	Heat shock factor (HSF)-type, DNA-binding

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 344 aa Download sequence Send to blast
MVAWEHGNGG GELSYTTGFL NEPTGKGDQT ESSIVKEEPD EEMRLFDDMI NGVGDWNNGW 60 PSASLPDVLP KPMEGLNDLG PPPFLRKTFE MVEDPKTDPI VSWSSGRNSF VVWDCHRLSE 120 NLLPKYFKHK NFSSFVRQLN TYGFRKIDSD RWEFANEGFQ GGRKHLLKNI KRRSRYNKQQ 180 QQGGVICIDN STNSRVGLEA DVEVLKQDHN SLQMDVSKLR QKQDNSNHRL SIVEERIHFA 240 DCKQRRMCSF LAKMIKYPNF IQQLLHKGKE LDHGKKFNKR RRLLETQVTT NPIEEPMDPI 300 QDEEFLVSMD DRVVPEMSRN EEVDVNDSKI YVELEQLVNW KPCS

Sequence ? help Back to Top

Protein Sequence Length: 344 aa Download sequence Send to blast

MVAWEHGNGG GELSYTTGFL NEPTGKGDQT ESSIVKEEPD EEMRLFDDMI NGVGDWNNGW  60
PSASLPDVLP KPMEGLNDLG PPPFLRKTFE MVEDPKTDPI VSWSSGRNSF VVWDCHRLSE  120
NLLPKYFKHK NFSSFVRQLN TYGFRKIDSD RWEFANEGFQ GGRKHLLKNI KRRSRYNKQQ  180
QQGGVICIDN STNSRVGLEA DVEVLKQDHN SLQMDVSKLR QKQDNSNHRL SIVEERIHFA  240
DCKQRRMCSF LAKMIKYPNF IQQLLHKGKE LDHGKKFNKR RRLLETQVTT NPIEEPMDPI  300
QDEEFLVSMD DRVVPEMSRN EEVDVNDSKI YVELEQLVNW KPCS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
2ldu_A	5e-22	82	173	18	120	Heat shock factor protein 1
5d5u_B	6e-22	82	173	27	129	Heat shock factor protein 1
5d5v_B	6e-22	82	173	27	129	Heat shock factor protein 1
5d5v_D	6e-22	82	173	27	129	Heat shock factor protein 1
5hdg_A	5e-22	82	173	8	110	Heat shock factor protein 1
5hdn_A	5e-22	82	173	8	110	Heat shock factor protein 1
5hdn_B	5e-22	82	173	8	110	Heat shock factor protein 1
5hdn_C	5e-22	82	173	8	110	Heat shock factor protein 1
5hdn_D	5e-22	82	173	8	110	Heat shock factor protein 1
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	166	172	LKNIKRR
2	278	282	KRRRL

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
Ghi.11692	0.0	root

Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress responses. Seems to be involved in other environmental stress responses. Activates ascorbate peroxidase 2 (APX2) in addition to several heat shock protein (HSPs). {ECO:0000269\|PubMed:16649111, ECO:0000269\|PubMed:17059409, ECO:0000269\|PubMed:17085506}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By heat stress, high light and hydrogen peroxide (H(2)O(2)). {ECO:0000269\|PubMed:16649111, ECO:0000269\|PubMed:17059409, ECO:0000269\|PubMed:17085506}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	KJ683909	0.0	KJ683909.1 Gossypium hirsutum heat shock transcription factor (HSF1) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_017625745.1	0.0	PREDICTED: heat stress transcription factor A-2-like
Swissprot	O80982	3e-81	HSFA2_ARATH; Heat stress transcription factor A-2
TrEMBL	A0A2P5WG79	0.0	A0A2P5WG79_GOSBA; Uncharacterized protein
STRING	Gorai.001G012700.1	0.0	(Gossypium raimondii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM7498	19	40

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G26150.1	1e-83	heat shock transcription factor A2

Publications ? help Back to Top
Liu HC,Charng YY Common and distinct functions of Arabidopsis class A1 and A2 heat shock factors in diverse abiotic stress responses and development. Plant Physiol., 2013. 163(1): p. 276-90 [PMID:23832625] Jung HS, et al. Subset of heat-shock transcription factors required for the early response of Arabidopsis to excess light. Proc. Natl. Acad. Sci. U.S.A., 2013. 110(35): p. 14474-9 [PMID:23918368] Chauhan H,Khurana N,Agarwal P,Khurana JP,Khurana P A seed preferential heat shock transcription factor from wheat provides abiotic stress tolerance and yield enhancement in transgenic Arabidopsis under heat stress environment. PLoS ONE, 2013. 8(11): p. e79577 [PMID:24265778] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Weng M, et al. Histone chaperone ASF1 is involved in gene transcription activation in response to heat stress in Arabidopsis thaliana. Plant Cell Environ., 2014. 37(9): p. 2128-38 [PMID:24548003] Jang YH, et al. A homolog of splicing factor SF1 is essential for development and is involved in the alternative splicing of pre-mRNA in Arabidopsis thaliana. Plant J., 2014. 78(4): p. 591-603 [PMID:24580679] Stief A, et al. Arabidopsis miR156 Regulates Tolerance to Recurring Environmental Stress through SPL Transcription Factors. Plant Cell, 2014. 26(4): p. 1792-1807 [PMID:24769482] Dobrá J, et al. The impact of heat stress targeting on the hormonal and transcriptomic response in Arabidopsis. Plant Sci., 2015. 231: p. 52-61 [PMID:25575991] Yamauchi Y,Kunishima M,Mizutani M,Sugimoto Y Reactive short-chain leaf volatiles act as powerful inducers of abiotic stress-related gene expression. Sci Rep, 2015. 5: p. 8030 [PMID:25619826] Shi H, et al. Melatonin induces class A1 heat-shock factors (HSFA1s) and their possible involvement of thermotolerance in Arabidopsis. J. Pineal Res., 2015. 58(3): p. 335-42 [PMID:25711624] Mueller SP,Krause DM,Mueller MJ,Fekete A Accumulation of extra-chloroplastic triacylglycerols in Arabidopsis seedlings during heat acclimation. J. Exp. Bot., 2015. 66(15): p. 4517-26 [PMID:25977236] Nie S,Yue H,Xing D A Potential Role for Mitochondrial Produced Reactive Oxygen Species in Salicylic Acid-Mediated Plant Acquired Thermotolerance. Plant Physiol., 2016. [PMID:26099269] Nguyen AH, et al. Loss of Arabidopsis 5'-3' Exoribonuclease AtXRN4 Function Enhances Heat Stress Tolerance of Plants Subjected to Severe Heat Stress. Plant Cell Physiol., 2015. 56(9): p. 1762-72 [PMID:26136597] Hu Z, et al. Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis. Plant J., 2015. 84(6): p. 1178-91 [PMID:26576681] Lämke J,Brzezinka K,Bäurle I HSFA2 orchestrates transcriptional dynamics after heat stress in Arabidopsis thaliana. Transcription, 2016. 7(4): p. 111-4 [PMID:27383578] Wang X,Huang W,Liu J,Yang Z,Huang B Molecular regulation and physiological functions of a novel FaHsfA2c cloned from tall fescue conferring plant tolerance to heat stress. Plant Biotechnol. J., 2017. 15(2): p. 237-248 [PMID:27500592] Chen ST,He NY,Chen JH,Guo FQ Identification of core subunits of photosystem II as action sites of HSP21, which is activated by the GUN5-mediated retrograde pathway in Arabidopsis. Plant J., 2017. 89(6): p. 1106-1118 [PMID:27943531] Kataoka R,Takahashi M,Suzuki N Coordination between bZIP28 and HSFA2 in the regulation of heat response signals in Arabidopsis. Plant Signal Behav, 2017. 12(11): p. e1376159 [PMID:28873003] Wang X,Zhuang L,Shi Y,Huang B Up-Regulation of HSFA2c and HSPs by ABA Contributing to Improved Heat Tolerance in Tall Fescue and Arabidopsis. Int J Mol Sci, 2018. [PMID:28914758] Llamas E,Pulido P,Rodriguez-Concepcion M Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis. PLoS Genet., 2017. 13(9): p. e1007022 [PMID:28937985] Li X, et al. Plastid Translation Elongation Factor Tu Is Prone to Heat-Induced Aggregation Despite Its Critical Role in Plant Heat Tolerance. Plant Physiol., 2018. 176(4): p. 3027-3045 [PMID:29444814]