PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Cotton_A_38746_BGI-A2_v1.0

Organism

Gossypium arboreum

Taxonomic ID

29729

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium

Family

E2F/DP

Protein Properties

Length: 479aa MW: 52935.2 Da PI: 4.8403

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cotton_A_38746_BGI-A2_v1.0	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	85.4	4.2e-27	157	222	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln +a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Cotton_A_38746_BGI-A2_v1.0 157 RYDSSLGLLTKKFVNLMKHAEDGILDLNRAAETL---EV--QKRRIYDITNVLEGIGLIEKKFKNRIQWKG 222 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	7.2E-29	154	223	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.5E-34	157	222	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	6.26E-17	157	220	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	3.1E-24	159	222	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	9.94E-34	235	339	No hit	No description
CDD	cd14660	3.79E-49	235	339	No hit	No description
Pfam	PF16421	1.0E-33	239	337	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 479 aa Download sequence Send to blast
MSGGAGASDG PTLPYQHPPT ASTTPASTIP PVVPPIRRHL AFASTKPPFV HPDDYHRFSS 60 SKSHGIVADQ EVEAIVVRSP QLKRKSAADK NEVESSQWTS SPGVTSISNS PFQTPVSAKG 120 GRINNRSKTS KANKSMPQTP VSNAGCPSPL TPAGSCRYDS SLGLLTKKFV NLMKHAEDGI 180 LDLNRAAETL EVQKRRIYDI TNVLEGIGLI EKKFKNRIQW KGVGASKPGE TDGDVSVIQE 240 EIENLSMEER RLDDQIREMQ ERLRDLSENE NNQKLLFVTE EDIKGIPCFQ NETLIAIKAP 300 HGTTLEVPDP DEDVDYRQRR YRIILRSTMG PIDVYLVSQF EEKFEEMNGV EPPLSFPLAS 360 SSGSNENQVE LVNTVSIRKE IEPQAQQTHQ ICSDINASQE SVGGMMRIVP SDIDNDADYW 420 LLSDADVSIT DMWKTDCVEW SGVDLLHSDF GMAEVGTPRP ETPPSRMTEV PSSDFKSSR

Sequence ? help Back to Top

Protein Sequence Length: 479 aa Download sequence Send to blast

MSGGAGASDG PTLPYQHPPT ASTTPASTIP PVVPPIRRHL AFASTKPPFV HPDDYHRFSS  60
SKSHGIVADQ EVEAIVVRSP QLKRKSAADK NEVESSQWTS SPGVTSISNS PFQTPVSAKG  120
GRINNRSKTS KANKSMPQTP VSNAGCPSPL TPAGSCRYDS SLGLLTKKFV NLMKHAEDGI  180
LDLNRAAETL EVQKRRIYDI TNVLEGIGLI EKKFKNRIQW KGVGASKPGE TDGDVSVIQE  240
EIENLSMEER RLDDQIREMQ ERLRDLSENE NNQKLLFVTE EDIKGIPCFQ NETLIAIKAP  300
HGTTLEVPDP DEDVDYRQRR YRIILRSTMG PIDVYLVSQF EEKFEEMNGV EPPLSFPLAS  360
SSGSNENQVE LVNTVSIRKE IEPQAQQTHQ ICSDINASQE SVGGMMRIVP SDIDNDADYW  420
LLSDADVSIT DMWKTDCVEW SGVDLLHSDF GMAEVGTPRP ETPPSRMTEV PSSDFKSSR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-25	152	224	2	75	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_017629499.1	0.0	PREDICTED: transcription factor E2FA-like
Swissprot	Q9FNY0	1e-179	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A2P5Y1W5	0.0	A0A2P5Y1W5_GOSBA; Uncharacterized protein
STRING	Gorai.007G366600.1	0.0	(Gossypium raimondii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM808	28	121

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-179	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]