PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cotton_A_36649_BGI-A2_v1.0
Common NameF383_33501
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family GRF
Protein Properties Length: 311aa    MW: 34991.9 Da    PI: 7.9736
Description GRF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cotton_A_36649_BGI-A2_v1.0genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRC78.65.9e-2568112145
                         WRC   1 daepgrCrRtDGKkWRCsrrvlegkklCErHlhrgrsrsrkskee 45 
                                 d+epgrCrRtDGKkWRCs+++++++k+CErH+hrgr+rsrk++e+
  Cotton_A_36649_BGI-A2_v1.0  68 DPEPGRCRRTDGKKWRCSKDAYPDSKYCERHMHRGRNRSRKPVES 112
                                 79****************************************986 PP

2QLQ64.42.8e-22642137
                         QLQ  1 saFTaaQlqlLksQilAyKyLaanqPvPpeLlqaiqk 37
                                s+FT +Q+q+L++Q+l++Ky++a++PvPp+L+++iqk
  Cotton_A_36649_BGI-A2_v1.0  6 SPFTVSQWQELEHQALIFKYMMAGLPVPPDLVLPIQK 42
                                89*********************************97 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM009511.1E-12642IPR014978Glutamine-Leucine-Glutamine, QLQ
PROSITE profilePS5166624.498742IPR014978Glutamine-Leucine-Glutamine, QLQ
PfamPF088803.4E-16741IPR014978Glutamine-Leucine-Glutamine, QLQ
PROSITE profilePS5166725.76268112IPR014977WRC domain
PfamPF088793.5E-2169111IPR014977WRC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005524Molecular FunctionATP binding
Sequence ? help Back to Top
Protein Sequence    Length: 311 aa     Download sequence    Send to blast
MAIRSSPFTV SQWQELEHQA LIFKYMMAGL PVPPDLVLPI QKSFESISHR FFHHPTMGYC  60
SFYGKKVDPE PGRCRRTDGK KWRCSKDAYP DSKYCERHMH RGRNRSRKPV ESQTMAQSSS  120
TVTSLTVSGN SGGTGSFQCL PLHAFSGTQQ VTASGPNQSH YHIESIPYGI PSKDHRYLEG  180
VKAEVSEASG SNRGFQIDTQ QENAWPVMQS RLSSFPQSKP SGNPSMLQND YPQHLFLSEF  240
NSGEPVKHEG QSLRPFFDEW PKTRDSWSAL EDERSNQTSF STTQLSISIP MASPDFSTTS  300
SRSPHGEFPT E
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that plays a role in the regulation of meristematic function in leaves, stems and inflorescences (PubMed:24532604). Transcription activator that plays a regulatory role in grain development (PubMed:26187814, PubMed:27250747, PubMed:27250749, PubMed:26936408, PubMed:27107174). Positively regulates grain size by promoting cell division and expansion, leading to increased grain length and width (PubMed:26187814, PubMed:27250747, PubMed:27250749, PubMed:26936408, PubMed:27107174). Positively regulates the expression of genes promoting cell proliferation (PubMed:26187814, PubMed:26936408). Activates the expression of expansin genes to promote cell expansion and grain size (PubMed:27250747). May promote grain size by activating brassinosteroid responses (PubMed:27250747). Component of a network formed by the microRNA396 (miRNA396), the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation (Probable). Component of the miRNA396c-GRF4-GIF1 regulatory module that plays an important role in grain size determination (Probable) (PubMed:27250747, PubMed:27250749, PubMed:27107174). {ECO:0000269|PubMed:24532604, ECO:0000269|PubMed:26187814, ECO:0000269|PubMed:26936408, ECO:0000269|PubMed:27107174, ECO:0000269|PubMed:27250747, ECO:0000269|PubMed:27250749, ECO:0000305|PubMed:26187814, ECO:0000305|PubMed:27107174, ECO:0000305|PubMed:27250747, ECO:0000305|PubMed:27250749}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: The microRNA396c negatively regulates GRF4 at the transcriptional level. {ECO:0000269|PubMed:26187814, ECO:0000269|PubMed:26936408, ECO:0000269|PubMed:27107174, ECO:0000269|PubMed:27250747}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017617893.10.0PREDICTED: growth-regulating factor 4-like
SwissprotQ6ZIK56e-87GRF4_ORYSJ; Growth-regulating factor 4
TrEMBLA0A0B0N4370.0A0A0B0N437_GOSAR; Dna double-strand break repair rad50 atpase
STRINGGorai.003G057700.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM143391019
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G13960.17e-46growth-regulating factor 5
Publications ? help Back to Top
  1. Kikuchi S, et al.
    Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice.
    Science, 2003. 301(5631): p. 376-9
    [PMID:12869764]
  2. Kuijt SJ, et al.
    Interaction between the GROWTH-REGULATING FACTOR and KNOTTED1-LIKE HOMEOBOX families of transcription factors.
    Plant Physiol., 2014. 164(4): p. 1952-66
    [PMID:24532604]
  3. Hu J, et al.
    A Rare Allele of GS2 Enhances Grain Size and Grain Yield in Rice.
    Mol Plant, 2015. 8(10): p. 1455-65
    [PMID:26187814]
  4. Sun P, et al.
    OsGRF4 controls grain shape, panicle length and seed shattering in rice.
    J Integr Plant Biol, 2016. 58(10): p. 836-847
    [PMID:26936408]
  5. Li S, et al.
    The OsmiR396c-OsGRF4-OsGIF1 regulatory module determines grain size and yield in rice.
    Plant Biotechnol. J., 2016. 14(11): p. 2134-2146
    [PMID:27107174]
  6. Che R, et al.
    Control of grain size and rice yield by GL2-mediated brassinosteroid responses.
    Nat Plants, 2015. 2: p. 15195
    [PMID:27250747]
  7. Duan P, et al.
    Regulation of OsGRF4 by OsmiR396 controls grain size and yield in rice.
    Nat Plants, 2015. 2: p. 15203
    [PMID:27250749]