PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Cotton_A_30259_BGI-A2_v1.0

Organism

Gossypium arboreum

Taxonomic ID

29729

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium

Family

E2F/DP

Protein Properties

Length: 351aa MW: 38308.6 Da PI: 4.3925

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cotton_A_30259_BGI-A2_v1.0	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	87	1.4e-27	111	176	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Cotton_A_30259_BGI-A2_v1.0 111 RYDSSLGLLTRKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 176 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	2.4E-29	108	178	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.09E-17	111	174	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	9.9E-35	111	176	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.1E-24	113	176	IPR003316	E2F/DP family, winged-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 351 aa Download sequence Send to blast
MKPPFMSPGG DYHHFASTES RRLADQKGDA IVVQSPRKSD VADREVESGD WARPPGYTEV 60 IGSPLQTPVS GKGGKAQKAS RLTKNSRSGP QIPASNLGSP GNNVTPTGPC RYDSSLGLLT 120 RKFINLIKQA EDGILDLNKA ADTLEVQKRR IYDITNVLEG IGLIEKKLKN RIQWKGLDVS 180 RPGEIDENVT TLQAEVENLS IEERCLDEQI SQFEEKFEEI QGADPPPNFP STSGLNENPA 240 TTMVPEESRG KEIEMQGQDD NKMCSDLNAS QDFVSGIMKI VPSDVDCDAD YWLLSDPSIS 300 IIDMWRTESL IEWSELGTLN EGYGMATVSS TCPQTPTSNA TEAPSANSTG K

Sequence ? help Back to Top

Protein Sequence Length: 351 aa Download sequence Send to blast

MKPPFMSPGG DYHHFASTES RRLADQKGDA IVVQSPRKSD VADREVESGD WARPPGYTEV  60
IGSPLQTPVS GKGGKAQKAS RLTKNSRSGP QIPASNLGSP GNNVTPTGPC RYDSSLGLLT  120
RKFINLIKQA EDGILDLNKA ADTLEVQKRR IYDITNVLEG IGLIEKKLKN RIQWKGLDVS  180
RPGEIDENVT TLQAEVENLS IEERCLDEQI SQFEEKFEEI QGADPPPNFP STSGLNENPA  240
TTMVPEESRG KEIEMQGQDD NKMCSDLNAS QDFVSGIMKI VPSDVDCDAD YWLLSDPSIS  300
IIDMWRTESL IEWSELGTLN EGYGMATVSS TCPQTPTSNA TEAPSANSTG K

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-27	106	177	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_012485148.1	0.0	PREDICTED: transcription factor E2FB-like isoform X7
Swissprot	Q9FV71	2e-79	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A1R3J2P0	1e-156	A0A1R3J2P0_COCAP; Uncharacterized protein
STRING	Gorai.006G114300.1	1e-147	(Gossypium raimondii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM808	28	121

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	6e-82	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]