PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Cotton_A_20638_BGI-A2_v1.0

Organism

Gossypium arboreum

Taxonomic ID

29729

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium

Family

NAC

Protein Properties

Length: 447aa MW: 50242.6 Da PI: 6.6938

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cotton_A_20638_BGI-A2_v1.0	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	96.5	4e-30	82	224	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkk......lelee.vikev.diykvePwdLpkkvkaeekewyfFskrdkkyatgkrkn 75 lp G++F+P+d el+ e+L++k+ + ++++ +++e +i++++P++Lp vk++ ++++fF+++ ++ya g+rk+ Cotton_A_20638_BGI-A2_v1.0 82 LPIGVKFDPSDIELL-EHLAAKCGIGDlkphpfIDEFIpTLNEDqGICYTHPQNLP-GVKKDGSSIHFFHQTINAYAIGQRKR 162 699**********.99988886665442222222333337******.67788899*************9 PP NAM 76 ra........tksgyWkatgkdkevlskkgelvglkktLvfy..kgrapkgektdWvmheyrl 128 r ++ +W++tgk+k+v++ +g +g kk++v+y ++r++k+ek++Wvmh+y+l Cotton_A_20638_BGI-A2_v1.0 163 RRiqnrhstiEEHVRWHKTGKTKPVIE-NGVRKGWKKIMVLYkrSNRTHKPEKSNWVMHQYHL 224 975666666555899********.999*******5446899999*******98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	1.44E-33	67	243	IPR003441	NAC domain
PROSITE profile	PS51005	28.293	82	243	IPR003441	NAC domain
Pfam	PF02365	8.2E-13	83	224	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 447 aa Download sequence Send to blast
MSFPEAEVQL PNLLSRSEAT VSRSVSASSS LNRSWFIDSR SIAKKVKNAI QITDTDCGAI 60 RECPNCHHRI DNSDVSPQWP GLPIGVKFDP SDIELLEHLA AKCGIGDLKP HPFIDEFIPT 120 LNEDQGICYT HPQNLPGVKK DGSSIHFFHQ TINAYAIGQR KRRRIQNRHS TIEEHVRWHK 180 TGKTKPVIEN GVRKGWKKIM VLYKRSNRTH KPEKSNWVMH QYHLGAEEVE VGGKYVVSKI 240 SYQQRKQTDK NDGVTRMEDS DNSIIRASPR TPKTMTPSPP RPWKSIIYEG DIDEKVHQES 300 KFAAEGSNLP IHGVECEDHL EYPLWLAGES QAAVNSEMNC LDNSSLQVKN SVKDRVSYAV 360 HDPGTMEMSA GNKDACTCGI SELENLEFDT PPDVSLSTSY EEDVAEVKYP NDKVKVFELL 420 ESLSRLFEAL EVVHPTGTAG LLSVSFR

Sequence ? help Back to Top

Protein Sequence Length: 447 aa Download sequence Send to blast

MSFPEAEVQL PNLLSRSEAT VSRSVSASSS LNRSWFIDSR SIAKKVKNAI QITDTDCGAI  60
RECPNCHHRI DNSDVSPQWP GLPIGVKFDP SDIELLEHLA AKCGIGDLKP HPFIDEFIPT  120
LNEDQGICYT HPQNLPGVKK DGSSIHFFHQ TINAYAIGQR KRRRIQNRHS TIEEHVRWHK  180
TGKTKPVIEN GVRKGWKKIM VLYKRSNRTH KPEKSNWVMH QYHLGAEEVE VGGKYVVSKI  240
SYQQRKQTDK NDGVTRMEDS DNSIIRASPR TPKTMTPSPP RPWKSIIYEG DIDEKVHQES  300
KFAAEGSNLP IHGVECEDHL EYPLWLAGES QAAVNSEMNC LDNSSLQVKN SVKDRVSYAV  360
HDPGTMEMSA GNKDACTCGI SELENLEFDT PPDVSLSTSY EEDVAEVKYP NDKVKVFELL  420
ESLSRLFEAL EVVHPTGTAG LLSVSFR

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	159	163	RKRRR
2	160	164	KRRRI

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269\|PubMed:19549833, ECO:0000269\|PubMed:20634150, ECO:0000269\|PubMed:24399300, ECO:0000305\|PubMed:24736489}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269\|PubMed:23907539}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_017628733.1	0.0	PREDICTED: NAC domain-containing protein 8-like
Swissprot	Q6NQK2	1e-82	NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBL	A0A2P5XGT0	0.0	A0A2P5XGT0_GOSBA; Uncharacterized protein
STRING	Gorai.007G075300.1	0.0	(Gossypium raimondii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM5045	26	51

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G14490.1	2e-96	NAC domain containing protein 85

Publications ? help Back to Top
Yi D, et al. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. Plant Cell, 2014. 26(1): p. 296-309 [PMID:24399300] Biever JJ,Brinkman D,Gardner G UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation. J. Exp. Bot., 2014. 65(11): p. 2949-61 [PMID:24591052] Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell, 2015. 27(1): p. 149-61 [PMID:25595823] Chen P,Umeda M DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana. Genes Cells, 2015. 20(8): p. 636-46 [PMID:26033196] Sjogren CA,Bolaris SC,Larsen PB Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response. Plant Cell, 2015. 27(9): p. 2501-15 [PMID:26320227] Yoshiyama KO SOG1: a master regulator of the DNA damage response in plants. Genes Genet. Syst., 2016. 90(4): p. 209-16 [PMID:26617076] Weimer AK, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J., 2016. 35(19): p. 2068-2086 [PMID:27497297] Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana. Genes Cells, 2016. 21(11): p. 1195-1208 [PMID:27658920] Pedroza-García JA, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol., 2017. 173(3): p. 1735-1749 [PMID:28153919] Horvath BM, et al. Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control. EMBO J., 2017. 36(9): p. 1261-1278 [PMID:28320736] Sjogren CA,Larsen PB SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Plant Cell Environ., 2017. 40(9): p. 1849-1860 [PMID:28556304] Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana. Plant Cell, 2017. 29(12): p. 3255-3268 [PMID:29208704] Johnson RA, et al. SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration. Plant Physiol., 2018. 176(2): p. 1665-1675 [PMID:29222192] Ogita N, et al. Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Plant J., 2018. 94(3): p. 439-453 [PMID:29430765] Cao X, et al. Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots. Chemosphere, 2018. 201: p. 586-594 [PMID:29533809]