PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cotton_A_10233_BGI-A2_v1.0
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family LSD
Protein Properties Length: 246aa    MW: 26579 Da    PI: 9.8238
Description LSD family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cotton_A_10233_BGI-A2_v1.0genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-LSD138.22.4e-1289113125
                     zf-LSD1   1 CggCrtlLsYPrGApsVRCalCdtV 25 
                                 C+gCr  L YPrGA++V+CalC+t+
  Cotton_A_10233_BGI-A2_v1.0  89 CSGCRSNLLYPRGATNVCCALCNTI 113
                                 ***********************97 PP

2zf-LSD138.32.2e-12128151124
                     zf-LSD1   1 CggCrtlLsYPrGApsVRCalCdt 24 
                                 CggCrtlL+Y rG +sVRC++C+t
  Cotton_A_10233_BGI-A2_v1.0 128 CGGCRTLLMYARGGTSVRCSCCHT 151
                                 ***********************8 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
TIGRFAMsTIGR010531.9E-1286116IPR005735Zinc finger, LSD1-type
PfamPF069432.7E-1089113IPR005735Zinc finger, LSD1-type
TIGRFAMsTIGR010539.8E-15125154IPR005735Zinc finger, LSD1-type
PfamPF069434.1E-10128151IPR005735Zinc finger, LSD1-type
Sequence ? help Back to Top
Protein Sequence    Length: 246 aa     Download sequence    Send to blast
MLKIFKKKTS PKDALRTSKR EMAVATRGVE REIASLQLEE KKLVAEIKKT AKTGNEARAL  60
DLNSIASRRI RIISSLKEGK SDMQSQIVCS GCRSNLLYPR GATNVCCALC NTITQVPLPG  120
MDMGQLICGG CRTLLMYARG GTSVRCSCCH TLNLAPGCLG TASSLFYMLH VHFFFLSFSL  180
VVSRLFSDTG NARAPFCVNR PNQIASAGTM PSTSTSQTVV VENPMSVDES GKLVSNVVVG  240
ITTDKK
Functional Description ? help Back to Top
Source Description
UniProtNegative regulator of reactive oxygen-induced cell death, cold stress-induced cell death, pathogen-induced hypersensitive response (HR), basal disease resistance. May be involved in the induction of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death. Antagonizes the function of BZIP10, a positive regulator of cell death, by interacting in the cytoplasm and preventing its nuclear localization. Controls lysigenous aerenchyma in hypocotyls under root hypoxia. Required for leaf acclimation in response to excess excitation energy. {ECO:0000269|PubMed:10550898, ECO:0000269|PubMed:11595797, ECO:0000269|PubMed:11844114, ECO:0000269|PubMed:12732715, ECO:0000269|PubMed:15347794, ECO:0000269|PubMed:16957775, ECO:0000269|PubMed:18055613, ECO:0000269|PubMed:18790826, ECO:0000269|PubMed:20456049, ECO:0000269|PubMed:21097903}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By methyl viologen. {ECO:0000269|PubMed:20456049}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016717493.12e-88PREDICTED: protein LSD1-like
RefseqXP_016717494.12e-88PREDICTED: protein LSD1-like
RefseqXP_017648816.12e-88PREDICTED: protein LSD1-like
SwissprotP940778e-45LSD1_ARATH; Protein LSD1
TrEMBLA0A2P5XBB33e-90A0A2P5XBB3_GOSBA; Uncharacterized protein
STRINGGorai.011G005300.13e-87(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM72932643
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G20380.71e-45LSD family protein
Publications ? help Back to Top
  1. Spedaletti V, et al.
    Characterization of a lysine-specific histone demethylase from Arabidopsis thaliana.
    Biochemistry, 2008. 47(17): p. 4936-47
    [PMID:18393445]
  2. Szechyńska-Hebda M,Czarnocka W,Hebda M,Bernacki MJ,Karpiński S
    PAD4, LSD1 and EDS1 regulate drought tolerance, plant biomass production, and cell wall properties.
    Plant Cell Rep., 2016. 35(3): p. 527-39
    [PMID:26754794]
  3. Czarnocka W, et al.
    The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator.
    Plant Cell Environ., 2017. 40(11): p. 2644-2662
    [PMID:28555890]
  4. Bernacki MJ, et al.
    LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana.
    Physiol Plant, 2019. 165(2): p. 369-382
    [PMID:30461017]