PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cotton_A_09611_BGI-A2_v1.0
Organism
Gossypium arboreum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family E2F/DP
Protein Properties Length: 468aa    MW: 51887.8 Da    PI: 4.5774
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cotton_A_09611_BGI-A2_v1.0genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.91.4e-27145210171
                     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                                 r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Cotton_A_09611_BGI-A2_v1.0 145 RYDSSLGLLTKKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 210
                                 6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.6E-29143212IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.0E-35145210IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.72E-17145208IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.0E-24147210IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146609.31E-49221327No hitNo description
SuperFamilySSF1440742.09E-33223327No hitNo description
PfamPF164219.6E-34226325IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 468 aa     Download sequence    Send to blast
MSDSQTPEQL KQPMQQQQQQ NRQPLKRQLP FSTKPPFMAS GGDYHRFAST EPRRVADHEA  60
EAIVVKSPLK RKSDLADREV ESSEWALPPG CTELGSSPLQ TPVSGKGGKA QKTSRLTKNS  120
KSGPQTPASN LGSPGNNLTP AGPCRYDSSL GLLTKKFINL IKQAEDGILD LNKAADTLEV  180
QKRRIYDITN VLEGIGLIEK KLKNRIQWKG LDVSRPGEVD DNVATLQAEV ENLSIEEHRL  240
DEKIREMQER LRDLSEDENN QKWLFVTEDD IKSLPCFQNE TLIAIKAPHG TTLEVPDPDE  300
AVDYSQRRYR IVLRSSMGPI DVYLVSQFEE KFEEIQGGDP PPNFPSTSGL NENSATAMAT  360
EESRGKEIEM QGHDANRMCS DLSASQDFVS GIMKIVPSEV DSDADYWLLS DPGVSITDMW  420
RTEPGVDWNE FETLHEDFGM GTVSAPGPQT PPPSNATEVP SNSTGRLP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-27140211274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017609642.10.0PREDICTED: transcription factor E2FB-like
SwissprotQ9FV711e-174E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A0D2LXW80.0A0A0D2LXW8_GOSRA; Uncharacterized protein
STRINGGorai.001G123900.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-176E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]