PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cotton_A_01469_BGI-A2_v1.0
Organism
Gossypium arboreum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family HD-ZIP
Protein Properties Length: 713aa    MW: 78202.6 Da    PI: 6.6691
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cotton_A_01469_BGI-A2_v1.0genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox65.66.5e-212883156
                                TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
                    Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                                +++ +++t++q+++Le++F+++++p++++r +L+++lgL  rq+k+WFqNrR+++k
  Cotton_A_01469_BGI-A2_v1.0 28 KKPYHRHTAHQIQRLESMFKECPHPDEKQRLQLSRELGLAPRQIKFWFQNRRTQMK 83
                                78999************************************************998 PP
2START178.53.8e-562274492206
                                 HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS........SCEEEEEEEECCSCHHHHHHHHHCCCGGCT- CS
                       START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv.......dsgealrasgvvdmvlallveellddkeqWd 73 
                                 +a  a++el+++ + +ep+W ks     + +n + + ++f++ ++        ++ea+r+sgvv+m+   lv  ++d++ +W 
  Cotton_A_01469_BGI-A2_v1.0 227 IAANAMEELLRLLQTNEPLWIKSTndgkDALNLESYERIFPKPNNthfkspnIRVEASRDSGVVIMNGLALVDMFMDSN-KWL 308
                                 67889********************99999999999999988777899***99**************************.*** PP

                                 TT-S....EEEEEEEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE- CS
                       START  74 etla....kaetlevissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRa 145
                                 e ++     a+t+evis+g      g lqlm+ elq+lsplvp R+f+++Ry++q ++g w+iv vS d +q+ ++     R+
  Cotton_A_01469_BGI-A2_v1.0 309 ELFPtivsIAKTIEVISPGmlgthsGSLQLMYEELQVLSPLVPtREFYTLRYCQQIEQGLWAIVNVSYDLPQFASQ----CRS 387
                                 ***999999****************************************************************987....*** PP

                                 EESSEEEEEEEECTCEEEEEEEE-EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
                       START 146 ellpSgiliepksnghskvtwvehvdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                                 ++lpSg+li++++ng+skvtw+ehv+ ++++p h l+r lv+sg a+ga +w+ tlqr ce+
  Cotton_A_01469_BGI-A2_v1.0 388 HRLPSGCLIQDMPNGYSKVTWLEHVEIEDKTPiHRLYRDLVHSGSAFGAERWLTTLQRMCER 449
                                 ************************************************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466897.52E-211185IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.607.3E-231379IPR009057Homeodomain-like
PROSITE profilePS5007117.9772585IPR001356Homeobox domain
SMARTSM003892.4E-192789IPR001356Homeobox domain
CDDcd000863.61E-192886No hitNo description
PfamPF000461.5E-182883IPR001356Homeobox domain
PROSITE patternPS0002706083IPR017970Homeobox, conserved site
PROSITE profilePS5084852.856217452IPR002913START domain
SuperFamilySSF559616.04E-39218450No hitNo description
CDDcd088751.30E-121221448No hitNo description
SMARTSM002345.2E-47226449IPR002913START domain
PfamPF018526.3E-49227449IPR002913START domain
Gene3DG3DSA:3.30.530.201.6E-7292431IPR023393START-like domain
SuperFamilySSF559611.65E-21470705No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 713 aa     Download sequence    Send to blast
MDCGSGGGGL GASGSGGDHD SSDLSRRKKP YHRHTAHQIQ RLESMFKECP HPDEKQRLQL  60
SRELGLAPRQ IKFWFQNRRT QMKAQHERAD NSALRAENDK IRCENIAIRE ALKNVICPSC  120
GGPPANEDSY FDDQKMRMEN AQLKEELDRV SSIAAKYIGR PISQLPPVQP VHISSLDFRM  180
ASFDGYGVGA GPSLDLDLLP GSSSSMPNLP FQPVVISDMD KSLMSDIAAN AMEELLRLLQ  240
TNEPLWIKST NDGKDALNLE SYERIFPKPN NTHFKSPNIR VEASRDSGVV IMNGLALVDM  300
FMDSNKWLEL FPTIVSIAKT IEVISPGMLG THSGSLQLMY EELQVLSPLV PTREFYTLRY  360
CQQIEQGLWA IVNVSYDLPQ FASQCRSHRL PSGCLIQDMP NGYSKVTWLE HVEIEDKTPI  420
HRLYRDLVHS GSAFGAERWL TTLQRMCERF ACLMVSSTST RDLGGVIPSP DGKRSIMKLA  480
QRMVNNFCTS VGTSNSHRST TLSGSNEIGV RVTVHKSSDP GQPNGIVLSA ATTFWLPVSP  540
QNVFSFFKDE RTRPQWDVLS NGNAVQEVAH IANGSHPGNC ISVLRAFNTS HNNMLILQES  600
CIDSSGSLVV YCPVDLPAIN VAMSGEDPSY IPLLPSGFTI TPDGHLEQGD GASTSSSTGH  660
GRSSGGSLIT VAFQILVSSL PSAKLNLDSV TTVNNLIGTT VQQIKAALNC PSS
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKJ5958470.0KJ595847.1 Gossypium hirsutum homeodomain protein HOX3-A (HOX3) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017635401.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A060AA380.0A0A060AA38_GOSHI; Homeodomain protein HOX3-A
STRINGGorai.008G293300.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM30042665
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]