PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

462934520

Organism

Eragrostis tef

Taxonomic ID

110835

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Chloridoideae; Eragrostideae; Eragrostidinae; Eragrostis

Family

E2F/DP

Protein Properties

Length: 395aa MW: 43475.5 Da PI: 5.2167

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
462934520	genome	Tef	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	84.9	6.4e-27	97	162	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++ll+++++gi++ln++a++L +v ++RRiYDi+NVLe+++liek+ kn+irwkg 462934520 97 RYDSSLGLLTKKFINLLKHAPDGILDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWKG 162 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	6.8E-29	94	164	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	4.08E-18	97	160	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.5E-35	97	162	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	2.9E-24	99	162	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.26E-49	172	278	No hit	No description
SuperFamily	SSF144074	1.15E-34	175	278	No hit	No description
Pfam	PF16421	7.0E-34	177	276	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 395 aa Download sequence Send to blast
RAAAAAPAAA TSGGVGAESI EEGLVIRTPL KRKAASEEND AAESSECMII SPMLTPVSGK 60 ASKTSKSKAK NNKAGPQTPT SNIGSPLNPS TPAGTCRYDS SLGLLTKKFI NLLKHAPDGI 120 LDLNNAAETL EVQKRRIYDI TNVLEGIGLI EKTLKNRIRW KGLDDSGSEL DNGVSALQAE 180 VENLSLQEQA LDERISDMRE KLRNLTEHEN NQRWLYVTED DIKGLPCFQN ETLIAIKAPH 240 GTTLEVPDPD EAGEYLQRRY RIVLRSTMGP IDVYLVSQFD EKIEDLGSAA TPAKHTNLPR 300 HQPAEDFNTI NAGQSSTSQD VVHNVQHIQK TPQDPSASQD FGGMTRIIPS DDRSQDRSSE 360 LQIDANFKFT FCCGYWWREP RYVKDSSNNS ENALR

Sequence ? help Back to Top

Protein Sequence Length: 395 aa Download sequence Send to blast

RAAAAAPAAA TSGGVGAESI EEGLVIRTPL KRKAASEEND AAESSECMII SPMLTPVSGK  60
ASKTSKSKAK NNKAGPQTPT SNIGSPLNPS TPAGTCRYDS SLGLLTKKFI NLLKHAPDGI  120
LDLNNAAETL EVQKRRIYDI TNVLEGIGLI EKTLKNRIRW KGLDDSGSEL DNGVSALQAE  180
VENLSLQEQA LDERISDMRE KLRNLTEHEN NQRWLYVTED DIKGLPCFQN ETLIAIKAPH  240
GTTLEVPDPD EAGEYLQRRY RIVLRSTMGP IDVYLVSQFD EKIEDLGSAA TPAKHTNLPR  300
HQPAEDFNTI NAGQSSTSQD VVHNVQHIQK TPQDPSASQD FGGMTRIIPS DDRSQDRSSE  360
LQIDANFKFT FCCGYWWREP RYVKDSSNNS ENALR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-24	89	163	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	462934520

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_004952668.1	0.0	transcription factor E2FA
Swissprot	Q9FNY0	1e-111	E2FA_ARATH; Transcription factor E2FA
TrEMBL	K3YS64	0.0	K3YS64_SETIT; Uncharacterized protein
STRING	Si017108m	0.0	(Setaria italica)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP625	37	148

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-107	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]