PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Thhalv10004487m
Common NameEUTSA_v10004487mg
Organism
Eutrema salsugineum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema
Family MYB
Protein Properties Length: 356aa    MW: 39462 Da    PI: 5.6831
Description MYB family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Thhalv10004487mgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding56.47e-181461148
                     TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS
  Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48
                     +g+WT+eEd +lv +++++G+g+W++++   g++R+ k+c++rw +yl
  Thhalv10004487m 14 KGPWTPEEDIILVSYIQEHGPGNWRSVPTNTGLKRCSKSCRLRWTNYL 61
                     79********************************************97 PP
2Myb_DNA-binding49.69.3e-1667112148
                      TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS
  Myb_DNA-binding   1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 
                      rg++T+ E++ +v++ ++lG++ W++Ia++++  Rt++++k++w+++l
  Thhalv10004487m  67 RGNFTEHEEKMIVHLQALLGNR-WAAIASYLP-ERTDNDIKNYWNTHL 112
                      89********************.*********.************996 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.601.1E-24564IPR009057Homeodomain-like
PROSITE profilePS5129425.515965IPR017930Myb domain
SuperFamilySSF466891.52E-3011108IPR009057Homeodomain-like
SMARTSM007175.9E-151363IPR001005SANT/Myb domain
PfamPF002491.5E-161461IPR001005SANT/Myb domain
CDDcd001672.78E-111661No hitNo description
Gene3DG3DSA:1.10.10.602.2E-2465117IPR009057Homeodomain-like
SMARTSM007177.7E-1666114IPR001005SANT/Myb domain
PROSITE profilePS5129419.41266116IPR017930Myb domain
PfamPF002494.9E-1467112IPR001005SANT/Myb domain
CDDcd001674.39E-1169112No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009414Biological Processresponse to water deprivation
GO:0009651Biological Processresponse to salt stress
GO:0009737Biological Processresponse to abscisic acid
GO:0009751Biological Processresponse to salicylic acid
GO:0010468Biological Processregulation of gene expression
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 356 aa     Download sequence    Send to blast
MGRPPCCEKT GVKKGPWTPE EDIILVSYIQ EHGPGNWRSV PTNTGLKRCS KSCRLRWTNY  60
LRPGIKRGNF TEHEEKMIVH LQALLGNRWA AIASYLPERT DNDIKNYWNT HLKKKLKKIN  120
EFGEEDNDGF SSSNTSSQKQ HQSSNKGQWE RRLQTDINMA KQALCEALSL DKPSSSTLSP  180
SSSPLSPVIV PQNIPSFSSA LLDRCYDLSS SSSSTTTTTT TTITSNTTTN PYPSGVYASS  240
AENIARLLQD FMKDTPKALT LTSSSPVSET GPLSAAACEE GGEGFEQSFF SFNSMEETQN  300
LTQETRFFHD QESKPVISMD QDHGLISQGS LSLLEKWLFD ENMVGMALEG QEAMF*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1mse_C2e-26141164105C-Myb DNA-Binding Domain
1msf_C2e-26141164105C-Myb DNA-Binding Domain
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator involved in the activation of cuticular wax biosynthesis under drought stress. Binds directly to DNA consensus sequences found in the promoters of genes encoding very-long-chain fatty acid-condensing enzymes involved in cuticular wax biosynthesis (PubMed:21398568). Functions together with MYB94 in the activation of cuticular wax biosynthesis (PubMed:27577115). Involved in drought stress response through abscisic acid (ABA) signaling. Mediates ABA signals that enhance plant resistance to drought by reducing stomatal opening. Mediates ABA-auxin cross-talk to regulate lateral root growth under drought stress conditions (PubMed:19625633). Involved in the regulation of ABA biosynthesis and ABA-dependent seed dormancy state. Binds to the promoters of NCED2 and NCED6, which are enzymes catalyzing the first step of ABA biosynthesis (PubMed:25616734). Regulates seed germination by controlling the expression of ABI4, a repressor of lipid breakdown during seed germination (PubMed:25869652). Binds to the promoter of LTP3 and transactivates LTP3 gene in response to drought stress and freezing (PubMed:23404903). Involved in cold stress response. Binds directly to the promoters of heptahelical protein (HHP) genes in response to cold stress. HHPs modulate the expression of SCRM/ICE1, SCRM2/ICE2 and CAMTA3, which are upstream regulators of cold-responsive C-repeat-binding factors (CBFs) (PubMed:25912720). Involved in defense responses against the bacterial pathogen Pseudomonas syringae. May act as a molecular link that mediates cross-talks between ABA and salicylate (PubMed:20149112). Involved in a crosstalk between the circadian clock and ABA signaling. Binds directly to the promoter of APRR1/TOC1 to activate its expression (PubMed:26725725). {ECO:0000269|PubMed:19625633, ECO:0000269|PubMed:20149112, ECO:0000269|PubMed:21398568, ECO:0000269|PubMed:23404903, ECO:0000269|PubMed:25616734, ECO:0000269|PubMed:25869652, ECO:0000269|PubMed:25912720, ECO:0000269|PubMed:26725725, ECO:0000269|PubMed:27577115}.
Function -- GeneRIF ? help Back to Top
  1. Enhanced expression of EsWAX1 improves drought tolerance with increased accumulation of cuticular wax and ascorbic acid in transgenic Arabidopsis. [EsWAX1]
    [PMID: 24361507]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00579DAPTransfer from AT5G62470Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapThhalv10004487m
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by drought stress, salt stress and abscisic acid (ABA) (PubMed:19625633). Induced by infection with the cauliflower mosaic virus (CaMV) (PubMed:10226370). Induced by cold stress (PubMed:25912720). {ECO:0000269|PubMed:10226370, ECO:0000269|PubMed:19625633, ECO:0000269|PubMed:25912720}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK3531670.0AK353167.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-26-J10.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006394392.10.0transcription factor MYB96
SwissprotQ24JK10.0MYB96_ARATH; Transcription factor MYB96
TrEMBLE4MXC00.0E4MXC0_EUTHA; mRNA, clone: RTFL01-26-J10
TrEMBLV4KWE50.0V4KWE5_EUTSA; Uncharacterized protein
STRINGXP_006394392.10.0(Eutrema salsugineum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM4282646
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G62470.20.0myb domain protein 96
Publications ? help Back to Top
  1. Geri C,Cecchini E,Giannakou ME,Covey SN,Milner JJ
    Altered patterns of gene expression in Arabidopsis elicited by cauliflower mosaic virus (CaMV) infection and by a CaMV gene VI transgene.
    Mol. Plant Microbe Interact., 1999. 12(5): p. 377-84
    [PMID:10226370]
  2. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  3. Zhu L,Guo J,Zhu J,Zhou C
    Enhanced expression of EsWAX1 improves drought tolerance with increased accumulation of cuticular wax and ascorbic acid in transgenic Arabidopsis.
    Plant Physiol. Biochem., 2014. 75: p. 24-35
    [PMID:24361507]
  4. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  5. Lee HG,Seo PJ
    The MYB96-HHP module integrates cold and abscisic acid signaling to activate the CBF-COR pathway in Arabidopsis.
    Plant J., 2015. 82(6): p. 962-77
    [PMID:25912720]
  6. Lee HG,Mas P,Seo PJ
    MYB96 shapes the circadian gating of ABA signaling in Arabidopsis.
    Sci Rep, 2016. 6: p. 17754
    [PMID:26725725]
  7. Cui F, et al.
    Dissecting Abscisic Acid Signaling Pathways Involved in Cuticle Formation.
    Mol Plant, 2016. 9(6): p. 926-38
    [PMID:27060495]
  8. Lee HG,Choi YR,Seo PJ
    Increased STM expression is associated with drought tolerance in Arabidopsis.
    J. Plant Physiol., 2016. 201: p. 79-84
    [PMID:27448723]
  9. Lee SB,Kim HU,Suh MC
    MYB94 and MYB96 Additively Activate Cuticular Wax Biosynthesis in Arabidopsis.
    Plant Cell Physiol., 2016. 57(11): p. 2300-2311
    [PMID:27577115]
  10. Lee HG,Seo PJ
    The Arabidopsis MIEL1 E3 ligase negatively regulates ABA signalling by promoting protein turnover of MYB96.
    Nat Commun, 2016. 7: p. 12525
    [PMID:27615387]
  11. Li P, et al.
    The Arabidopsis UGT87A2, a stress-inducible family 1 glycosyltransferase, is involved in the plant adaptation to abiotic stresses.
    Physiol Plant, 2017. 159(4): p. 416-432
    [PMID:27747895]
  12. Lee HG,Kim J,Suh MC,Seo PJ
    The MIEL1 E3 Ubiquitin Ligase Negatively Regulates Cuticular Wax Biosynthesis in Arabidopsis Stems.
    Plant Cell Physiol., 2017. 58(7): p. 1249-1259
    [PMID:28838126]
  13. Lee HG,Kim H,Suh MC,Kim HU,Seo PJ
    The MYB96 Transcription Factor Regulates Triacylglycerol Accumulation by Activating DGAT1 and PDAT1 Expression in Arabidopsis Seeds.
    Plant Cell Physiol., 2018. 59(7): p. 1432-1442
    [PMID:29660088]
  14. Lee HG,Seo PJ
    MYB96 recruits the HDA15 protein to suppress negative regulators of ABA signaling in Arabidopsis.
    Nat Commun, 2019. 10(1): p. 1713
    [PMID:30979883]