PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Do021429.1

Organism

Dichanthelium oligosanthes

Taxonomic ID

888268

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Panicodae; Paniceae; Dichantheliinae; Dichanthelium

Family

bHLH

Protein Properties

Length: 389aa MW: 41365.2 Da PI: 5.6569

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Do021429.1	genome	Dichan	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	41.5	2.5e-13	159	210	1	55
CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +r++h ++Er+RR+++N+ + Lr+l+P + + ++ + a+i A+e+I++L+ Do021429.1 159 QRMTHIAVERNRRRQMNEYLRILRSLMPGS---YVQRGDQASIIGGAIEFIRELE 210 79**************************...9****************996 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
CDD	cd00083	1.77E-14	157	214	No hit	No description
Gene3D	G3DSA:4.10.280.10	2.2E-13	157	213	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	9.81E-17	158	223	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	15.847	158	209	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	9.7E-11	159	210	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	1.0E-9	164	215	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0010377	Biological Process	guard cell fate commitment
GO:0045597	Biological Process	positive regulation of cell differentiation
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051782	Biological Process	negative regulation of cell division
GO:0005634	Cellular Component	nucleus
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 389 aa Download sequence Send to blast
MVDYMLGQAP PPAQTTPQSQ VSFDKLSFSD VLQFADFGPK LALNQPAASA GARDGVDNGA 60 DDDDDGYFFR FQSLPSLLGA AAPPRGSAGQ QHHADHEGSK TTAEDGGAHD GCGAGVSEST 120 TLVQNADGGG RAEKGGDQGK SGRRKRPRSV KTSEEVESQR MTHIAVERNR RRQMNEYLRI 180 LRSLMPGSYV QRGDQASIIG GAIEFIRELE QLIQCLESQK RRRLYGGSGD APRPVVDAAG 240 AGAPTSTQQH HQPQVPPATP FFPPSLPFPV ASGGCGDGAA AKILDLEAGG ADAGGLREEV 300 AENKSCLADI EVRALGADAM IKILSRRRPG QLIKTIAALE DMQMSILHTN ITTIEQTVLY 360 SFNCFSSVSL TLLWVPTAIK LPSSQDDSI

Sequence ? help Back to Top

Protein Sequence Length: 389 aa Download sequence Send to blast

MVDYMLGQAP PPAQTTPQSQ VSFDKLSFSD VLQFADFGPK LALNQPAASA GARDGVDNGA  60
DDDDDGYFFR FQSLPSLLGA AAPPRGSAGQ QHHADHEGSK TTAEDGGAHD GCGAGVSEST  120
TLVQNADGGG RAEKGGDQGK SGRRKRPRSV KTSEEVESQR MTHIAVERNR RRQMNEYLRI  180
LRSLMPGSYV QRGDQASIIG GAIEFIRELE QLIQCLESQK RRRLYGGSGD APRPVVDAAG  240
AGAPTSTQQH HQPQVPPATP FFPPSLPFPV ASGGCGDGAA AKILDLEAGG ADAGGLREEV  300
AENKSCLADI EVRALGADAM IKILSRRRPG QLIKTIAALE DMQMSILHTN ITTIEQTVLY  360
SFNCFSSVSL TLLWVPTAIK LPSSQDDSI

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	159	170	RMTHIAVERNRR
2	219	223	KRRRL

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269\|PubMed:17088607, ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267, ECO:0000269\|PubMed:24571519, ECO:0000269\|PubMed:24654956}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Do021429.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269\|PubMed:22442411}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	KJ727750	1e-129	KJ727750.1 Zea mays clone pUT5691 bHLH transcription factor (bHLH22) mRNA, partial cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_025805324.1	0.0	transcription factor FAMA isoform X1
Swissprot	Q56YJ8	6e-98	FAMA_ARATH; Transcription factor FAMA
TrEMBL	A0A1E5UZM7	0.0	A0A1E5UZM7_9POAL; Transcription factor FAMA
STRING	Pavir.J03740.1.p	0.0	(Panicum virgatum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP9502	33	40

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G24140.1	9e-55	bHLH family protein

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Matos JL, et al. Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] Chen L, et al. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] Li X,Yang R,Chen H The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]