PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Dca18460.1
Organism
Dianthus caryophyllus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Caryophyllales; Caryophyllaceae; Caryophylleae; Dianthus
Family E2F/DP
Protein Properties Length: 405aa    MW: 45188.8 Da    PI: 9.153
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Dca18460.1genomeDCAView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.45e-232085171
     E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                rk+ksL+ll+++fl+l+++   + + l+++a +L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Dca18460.1 20 RKQKSLGLLCSNFLRLYNRDGVDSIGLDDAACKL---GV--ERRRIYDIVNVLESVGVLARKAKNQYSWKG 85
                79*****************999************...**..****************************98 PP
2E2F_TDP78.65.8e-25150230171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                 r+eksL+lltq+f+kl+ +s+++ +tl+e+ak L+ +      +++k+RR+YDi+NVL++++liek     ++k+++rw g
  Dca18460.1 150 RREKSLGLLTQNFVKLFLCSDAELITLDEAAKCLLGDglnavVMRTKVRRLYDIANVLSSMQLIEKtnqkeSRKPAFRWLG 230
                 689**************************************999**********************999888999999987 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.105.2E-251687IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.76E-151983IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.8E-262085IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.3E-192185IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.6E-23146231IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.0E-29150230IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.76E-13152231IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.4E-19152230IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 405 aa     Download sequence    Send to blast
MASPVQSPSE TGSLHHGYSR KQKSLGLLCS NFLRLYNRDG VDSIGLDDAA CKLGVERRRI  60
YDIVNVLESV GVLARKAKNQ YSWKGFKAIP KALALLKEEG LKENFGSAEG RSRVKFQVLD  120
FDDDVASNPD TGSQSEVPNP NGAPKSDNNR REKSLGLLTQ NFVKLFLCSD AELITLDEAA  180
KCLLGDGLNA VVMRTKVRRL YDIANVLSSM QLIEKTNQKE SRKPAFRWLG LREKAEGAVS  240
GLPFSTEPRK RTFGTDLSNI NFKRTKVDHS VGEGSKQQIN LKVKIENIEN EFYTTSSEEP  300
KSSSRSYQYG PFAPVTVAKV GIAEPKTSRR VHDLESLATS YRPQYHNQAL RDLFDHYVEA  360
WSSWYSEVAA HSNITAPHWT HSLDALNHTD QERGTVIGNI AAPHY
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-39192223228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010678680.10.0PREDICTED: E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-126E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A0K9R2D51e-176A0A0K9R2D5_SPIOL; Uncharacterized protein
STRINGXP_010678681.10.0(Beta vulgaris)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-119DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]