PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

DCAR_023688

Organism

Daucus carota

Taxonomic ID

4039

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Apiales; Apiineae; Apiaceae; Apioideae; Scandiceae; Daucinae; Daucus

Family

NAC

Protein Properties

Length: 521aa MW: 58273.1 Da PI: 4.8088

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
DCAR_023688	genome	ARS-USDA	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	102.4	6.1e-32	58	197	1	128
NAM 1 lppGfrFhPtdeelvveyLkkk.vegkk.....leleevikevd....iykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratk.....sgyW 83 lp+G++F+Ptd+e++ + L+k +e+ + +e+i++vd i++++P++Lp vk++ + +fF+++ k+y+tg+rk+r+++ + +W DCAR_023688 58 LPRGVKFDPTDQEILGHLLAKAgCEN-LkphpfI--DEFITTVDkddgICYTHPQNLP-GVKQDGSVSHFFHRAIKAYNTGTRKRRKIHgddlgDVRW 151 699**********88777663333.2465432..334555544556******.677888899***************86555655889 PP NAM 84 katgkdkevlskkgelvglkktLvfykg..rapkgektdWvmheyrl 128 ++tg++k+v+ +g ++g+kk++v+y + + k+ekt+Wvmh+y+l DCAR_023688 152 HKTGRTKPVIL-DGVQKGCKKIMVLYVNvlKGGKAEKTNWVMHQYHL 197 *********.99********4434777888*******98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	1.7E-37	43	216	IPR003441	NAC domain
PROSITE profile	PS51005	30.327	58	216	IPR003441	NAC domain
Pfam	PF02365	8.0E-14	59	197	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000077	Biological Process	DNA damage checkpoint
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010332	Biological Process	response to gamma radiation
GO:0040020	Biological Process	regulation of meiotic nuclear division
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 521 aa Download sequence Send to blast
MAGSSWLVDG HRIATKIKSA SGAYDLERVS WKSNPTKACP NCNHIVDNSD VTEQWPGLPR 60 GVKFDPTDQE ILGHLLAKAG CENLKPHPFI DEFITTVDKD DGICYTHPQN LPGVKQDGSV 120 SHFFHRAIKA YNTGTRKRRK IHGDDLGDVR WHKTGRTKPV ILDGVQKGCK KIMVLYVNVL 180 KGGKAEKTNW VMHQYHLGTG EDEMEGDYVI SKVFYQQQQV KQSEKGEAPL SDGIDDALVT 240 DIHQISPKSV TPETSRPERC FPDYDEEKDL APTSVVIPAK HIELECHEDV VITVSEKHND 300 QDHFVAESND HQMGVDDEKK DGDTMNGCDN GSQYLLDSEE LAEAMTLRDE LLQSQTSNKN 360 VNIKEEINGK SKSSHTDDEN HAGEDMIGWG DSESQYLLDS QQMVEAMTLC DELLQSQSPD 420 RNGSGIRKFD GKPSLSDYAY LGSETLKRDL EDCQALALDP ANIDVDSAPD FRLSQLVSYA 480 ISFRFCFLLA RLICCLYFQK LNIYCIKCLQ EFGSQDSFVL *

Sequence ? help Back to Top

Protein Sequence Length: 521 aa Download sequence Send to blast

MAGSSWLVDG HRIATKIKSA SGAYDLERVS WKSNPTKACP NCNHIVDNSD VTEQWPGLPR  60
GVKFDPTDQE ILGHLLAKAG CENLKPHPFI DEFITTVDKD DGICYTHPQN LPGVKQDGSV  120
SHFFHRAIKA YNTGTRKRRK IHGDDLGDVR WHKTGRTKPV ILDGVQKGCK KIMVLYVNVL  180
KGGKAEKTNW VMHQYHLGTG EDEMEGDYVI SKVFYQQQQV KQSEKGEAPL SDGIDDALVT  240
DIHQISPKSV TPETSRPERC FPDYDEEKDL APTSVVIPAK HIELECHEDV VITVSEKHND  300
QDHFVAESND HQMGVDDEKK DGDTMNGCDN GSQYLLDSEE LAEAMTLRDE LLQSQTSNKN  360
VNIKEEINGK SKSSHTDDEN HAGEDMIGWG DSESQYLLDS QQMVEAMTLC DELLQSQSPD  420
RNGSGIRKFD GKPSLSDYAY LGSETLKRDL EDCQALALDP ANIDVDSAPD FRLSQLVSYA  480
ISFRFCFLLA RLICCLYFQK LNIYCIKCLQ EFGSQDSFVL *

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269\|PubMed:19549833, ECO:0000269\|PubMed:20634150, ECO:0000269\|PubMed:24399300, ECO:0000305\|PubMed:24736489}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269\|PubMed:23907539}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_017215347.1	0.0	PREDICTED: NAC domain-containing protein 8
Swissprot	Q6NQK2	1e-161	NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBL	A0A164SS08	0.0	A0A164SS08_DAUCS; Uncharacterized protein
STRING	cassava4.1_008059m	1e-178	(Manihot esculenta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA8162	24	30

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G25580.1	1e-163	NAC family protein

Link Out ? help Back to Top
Phytozome	DCAR_023688

Publications ? help Back to Top
Yi D, et al. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. Plant Cell, 2014. 26(1): p. 296-309 [PMID:24399300] Biever JJ,Brinkman D,Gardner G UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation. J. Exp. Bot., 2014. 65(11): p. 2949-61 [PMID:24591052] Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell, 2015. 27(1): p. 149-61 [PMID:25595823] Chen P,Umeda M DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana. Genes Cells, 2015. 20(8): p. 636-46 [PMID:26033196] Sjogren CA,Bolaris SC,Larsen PB Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response. Plant Cell, 2015. 27(9): p. 2501-15 [PMID:26320227] Yoshiyama KO SOG1: a master regulator of the DNA damage response in plants. Genes Genet. Syst., 2016. 90(4): p. 209-16 [PMID:26617076] Weimer AK, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J., 2016. 35(19): p. 2068-2086 [PMID:27497297] Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana. Genes Cells, 2016. 21(11): p. 1195-1208 [PMID:27658920] Pedroza-García JA, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol., 2017. 173(3): p. 1735-1749 [PMID:28153919] Horvath BM, et al. Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control. EMBO J., 2017. 36(9): p. 1261-1278 [PMID:28320736] Sjogren CA,Larsen PB SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Plant Cell Environ., 2017. 40(9): p. 1849-1860 [PMID:28556304] Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana. Plant Cell, 2017. 29(12): p. 3255-3268 [PMID:29208704] Johnson RA, et al. SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration. Plant Physiol., 2018. 176(2): p. 1665-1675 [PMID:29222192] Ogita N, et al. Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Plant J., 2018. 94(3): p. 439-453 [PMID:29430765] Cao X, et al. Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots. Chemosphere, 2018. 201: p. 586-594 [PMID:29533809]