PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID DCAR_016509
Organism
Daucus carota
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Apiales; Apiineae; Apiaceae; Apioideae; Scandiceae; Daucinae; Daucus
Family E2F/DP
Protein Properties Length: 338aa    MW: 37930.2 Da    PI: 9.6773
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
DCAR_016509genomeARS-USDAView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP44.91.9e-146354271
      E2F_TDP 42 krRRiYDilNVLealnliekkekneirwkg 71
                 +rRRiYDi+NVLe+++l++kk+kn+++wkg
  DCAR_016509  6 ERRRIYDIVNVLESIGLLTKKAKNRYSWKG 35
                 8***************************98 PP
2E2F_TDP80.81.2e-25105185171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                  rkeksL+lltq+f+kl+ +se ++++l+e+ak L+ +      +++k+RR+YDi+NVL+++n iek     ++k+++rw g
  DCAR_016509 105 RKEKSLGLLTQNFVKLFLCSEVEMISLDEAAKILLGDahdmsMMRTKVRRLYDIANVLSSMNFIEKthhpeTRKPAFRWLG 185
                  79***************************************999***********************99999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM013720.0012135IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.5E-13436IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467859.52E-10436IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023194.3E-12535IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.1E-25101186IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.1E-34105185IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.9E-20106185IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.29E-13107186IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 338 aa     Download sequence    Send to blast
MFSGVERRRI YDIVNVLESI GLLTKKAKNR YSWKGFGVIP KTLQLLKQEG LKESYTSFED  60
PLPFKVLDDE VDEKFQSSNN SSQTDKSNAS SVPKIPGLGA SKSERKEKSL GLLTQNFVKL  120
FLCSEVEMIS LDEAAKILLG DAHDMSMMRT KVRRLYDIAN VLSSMNFIEK THHPETRKPA  180
FRWLGMKGKS QMASTNALIL ESKKRTFGTE LTNTSLKRCR GAPSLNTAAD QATITPSQIR  240
AECMTAKKAV DVSDSEKGSL QNVQNYHYGP FAPINVLKTQ PSSNDERKQP RDWESLAKAH  300
TPQYHNQALR DLFCHYMEAW GSWCSEVAGK NPIQLQS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-34417742228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017251416.10.0PREDICTED: E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ42e-98E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A164XJK50.0A0A164XJK5_DAUCS; Uncharacterized protein
STRINGXP_009607525.11e-125(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-100DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]