PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

DCAR_013863

Organism

Daucus carota

Taxonomic ID

4039

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Apiales; Apiineae; Apiaceae; Apioideae; Scandiceae; Daucinae; Daucus

Family

E2F/DP

Protein Properties

Length: 393aa MW: 44492.7 Da PI: 6.9733

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
DCAR_013863	genome	ARS-USDA	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	82.1	4.7e-26	137	201	1	70
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 r+++sL+llt+kf++l++++++g+++ln+ a+ L +v ++RRiYDi+NVLe+++liek++kn+irwk DCAR_013863 137 RYDSSLGLLTKKFISLIHEAKDGTLDLNKTADVL---EV--RKRRIYDITNVLEGIGLIEKTAKNHIRWK 201 6899****************************...99..9*************************8 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.2E-26	134	202	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.3E-32	137	202	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	7.75E-17	137	200	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	5.3E-24	139	201	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	4.18E-24	216	317	No hit	No description
Pfam	PF16421	8.9E-23	217	315	IPR032198	E2F transcription factor, CC-MB domain
CDD	cd14660	1.71E-32	219	318	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 393 aa Download sequence Send to blast
MASSAAGGGG GEELSRHLSA IHLHHQQHPH FYNTNTITQT HDIHIKKKPG RKRNYQNPFI 60 SPSPPAPTFQ PANIVGEDKG KSDETTTIHE YSNKHSAGVE HSPNLKVIRK PKVSIVKSEQ 120 ESYAENAENL NLATSCRYDS SLGLLTKKFI SLIHEAKDGT LDLNKTADVL EVRKRRIYDI 180 TNVLEGIGLI EKTAKNHIRW KDFDTKLRES EFHAAQLMAE IKSLYAEDNR VENLIRKTKE 240 QLRDLKFGQT SQKYLFVTEK DIMSLPHFKN QTVMVIKAPH ASYVEVPDPD EGNFARKEYR 300 LLVRSTTGPI NLFLLSKHDG EGEDDAVNDI KLSDASFRNG GRYQDENNFH SEESNMYKLD 360 KIVPSDSHID DDYWLRSDDS VCASDLWGTK HT*

Sequence ? help Back to Top

Protein Sequence Length: 393 aa Download sequence Send to blast

MASSAAGGGG GEELSRHLSA IHLHHQQHPH FYNTNTITQT HDIHIKKKPG RKRNYQNPFI  60
SPSPPAPTFQ PANIVGEDKG KSDETTTIHE YSNKHSAGVE HSPNLKVIRK PKVSIVKSEQ  120
ESYAENAENL NLATSCRYDS SLGLLTKKFI SLIHEAKDGT LDLNKTADVL EVRKRRIYDI  180
TNVLEGIGLI EKTAKNHIRW KDFDTKLRES EFHAAQLMAE IKSLYAEDNR VENLIRKTKE  240
QLRDLKFGQT SQKYLFVTEK DIMSLPHFKN QTVMVIKAPH ASYVEVPDPD EGNFARKEYR  300
LLVRSTTGPI NLFLLSKHDG EGEDDAVNDI KLSDASFRNG GRYQDENNFH SEESNMYKLD  360
KIVPSDSHID DDYWLRSDDS VCASDLWGTK HT*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-24	133	201	3	72	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12468727, ECO:0000269\|PubMed:16920782, ECO:0000269\|PubMed:19662336}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Down-regulated by light. {ECO:0000269\|PubMed:12468727, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_017246087.1	0.0	PREDICTED: transcription factor E2FC-like isoform X1
Swissprot	Q9FV70	4e-78	E2FC_ARATH; Transcription factor E2FC
TrEMBL	A0A165Y2Q2	0.0	A0A165Y2Q2_DAUCS; Uncharacterized protein
STRING	VIT_18s0001g14110.t01	2e-98	(Vitis vinifera)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA12625	20	22

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G47870.2	2e-80	E2F/DP family protein

Link Out ? help Back to Top
Phytozome	DCAR_013863

Publications ? help Back to Top
Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470] Huntley R, et al. The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins. Plant Mol. Biol., 1998. 37(1): p. 155-69 [PMID:9620273]