PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID orange1.1g046202m
Organism
Citrus sinensis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus
Family HD-ZIP
Protein Properties Length: 448aa    MW: 51449.6 Da    PI: 6.5527
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
orange1.1g046202mgenomeICGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox61.81.1e-192272656
                       S--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
           Homeobox  6 tftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                       ++t++q+++Le++F+ +++p++++r++L+k+lgL+ +q+k+WFqN+R++ k
  orange1.1g046202m 22 RHTTHQIQTLEAFFKDCPHPDENQRRQLSKELGLDLKQIKFWFQNKRTQTK 72
                       689********************************************9987 PP
2START132.83.9e-422114343206
                        HHHHHHHHHHHHHHC-TT-EEEE.EXCCTTEEEEEEESSS............SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....E CS
              START   3 aeeaaqelvkkalaeepgWvkss.esengdevlqkfeeskv...........dsgealrasgvvdmvlallveellddkeqWdetla....k 78 
                        a  a++el++++  +ep+W k + + +++ +v+  ++ +kv            ++e ++ sg+v+m+ ++lve lld+  +W   ++    k
  orange1.1g046202m 211 ATNAMDELIRLMRINEPLWIKPPsSTNIERYVIHPESYEKVfpranhfktssARVESSKYSGMVTMNGMQLVEMLLDSD-KWVDLFPtivsK 301
                        5689*******************54444444444444455599999*****99**************************.99999999999* PP

                        EEEEEEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEE CS
              START  79 aetlevissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghsk 163
                        a t++v+++g      g lqlm  ++  lsplv+ R+++f+R+++q + g wvivdvS + ++++ +ss++ R   lpSg++i+++ ng s+
  orange1.1g046202m 302 ARTIQVLEPGingnrnGCLQLMHEQMHILSPLVSpREYYFLRHCQQIELGLWVIVDVSYEWPKDNISSSHCWR---LPSGFMIQDMTNGCSN 390
                        *******************************9999*****************************986777776...**************** PP

                        EEEEE-EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
              START 164 vtwvehvdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                        vtw+ehv++++++  h l+r l+ +  a ga +wv tlqr ce+
  orange1.1g046202m 391 VTWLEHVEVDDKTQtHRLYRDLICNNCAYGAERWVVTLQRTCER 434
                        ***********9998***************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.601.7E-19468IPR009057Homeodomain-like
SuperFamilySSF466898.36E-181178IPR009057Homeodomain-like
PROSITE profilePS5007115.6771474IPR001356Homeobox domain
SMARTSM003899.9E-171478IPR001356Homeobox domain
CDDcd000864.34E-162175No hitNo description
PfamPF000464.0E-172272IPR001356Homeobox domain
PROSITE patternPS0002704972IPR017970Homeobox, conserved site
PROSITE profilePS5084840.482200437IPR002913START domain
SuperFamilySSF559611.04E-30202435No hitNo description
CDDcd088751.44E-103204433No hitNo description
SMARTSM002344.4E-29209434IPR002913START domain
PfamPF018521.2E-35211434IPR002913START domain
Gene3DG3DSA:3.30.530.205.6E-6256398IPR023393START-like domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008289Molecular Functionlipid binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 448 aa     Download sequence    Send to blast
GDLGDEQDAT NSQNKGKITC HRHTTHQIQT LEAFFKDCPH PDENQRRQLS KELGLDLKQI  60
KFWFQNKRTQ TKAQNERANN SVLRAENERV HCENLAIREA LKNVICPSCG GPPFGIEERQ  120
RSLQKLQLEN SQLKEEHEKV SNLLAKYIGK PICQMNSSLM PSLPGSAILE HQNVLPPPIL  180
PVHQEMDIGL DLNLQFKGIN DLEQSLMMET ATNAMDELIR LMRINEPLWI KPPSSTNIER  240
YVIHPESYEK VFPRANHFKT SSARVESSKY SGMVTMNGMQ LVEMLLDSDK WVDLFPTIVS  300
KARTIQVLEP GINGNRNGCL QLMHEQMHIL SPLVSPREYY FLRHCQQIEL GLWVIVDVSY  360
EWPKDNISSS HCWRLPSGFM IQDMTNGCSN VTWLEHVEVD DKTQTHRLYR DLICNNCAYG  420
AERWVVTLQR TCERLLAENS QSIHEVGG
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: During embryo development, expressed in all cells at the 4- and 16-cell embryo stages. Expression is restricted to the protoderm from the globular stage onward. {ECO:0000269|PubMed:25564655}.
UniprotTISSUE SPECIFICITY: Expressed in apical meristems and young epidermal tissue including trichomes and stipules. Expressed in lateral root tips, the L1 layer of apical inflorescence meristems and early flower primordia, carpel and petal epidermis, stigma papillae, ovule primordia, nucellus and embryo. {ECO:0000269|PubMed:16778018}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006421085.10.0homeobox-leucine zipper protein ROC8
SwissprotQ9FX311e-140HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A2H5PLL60.0A0A2H5PLL6_CITUN; Uncharacterized protein
TrEMBLV4S6730.0V4S673_9ROSI; Uncharacterized protein
STRINGXP_006421085.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM2405323
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.11e-143homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]