PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Cucsa.283900.1

Organism

Cucumis sativus

Taxonomic ID

3659

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis

Family

NAC

Protein Properties

Length: 591aa MW: 66506.7 Da PI: 5.4528

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cucsa.283900.1	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	104.1	1.9e-32	253	392	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkk.....lelee.....vikevdiykvePwdLpkkvkaeekewyfFskrdkkyatgkrknr.atk....s 80 lp+G++F+P+d+e++++ L+k g + + + v+++ +i++++P++Lp vk++ + +fF+++ k+y+tg+rk+r +t+ + Cucsa.283900.1 253 LPRGVKFDPSDQEIIWHLLAKVGIGGSrphpfI---DefiptVFEDDGICYTHPQKLP-GVKQDGSVSHFFHRAIKAYNTGTRKRRkITDddfgD 343 699**********888887744444476552...233333577778******.677888899**************555466557 PP NAM 81 gyWkatgkdkevlskkgelvglkktLvfykg..rapkgektdWvmheyrl 128 +W++tg++k+v+ +g ++g+kk++v+y + ++ekt+Wvmh+y+l Cucsa.283900.1 344 VRWHKTGRTKPVVI-DGVQKGCKKIMVLYMSfaKGGRAEKTNWVMHQYHL 392 88********.99********6522666778*******98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	3.27E-39	238	411	IPR003441	NAC domain
PROSITE profile	PS51005	31.137	253	411	IPR003441	NAC domain
Pfam	PF02365	2.2E-13	254	392	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000077	Biological Process	DNA damage checkpoint
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010332	Biological Process	response to gamma radiation
GO:0040020	Biological Process	regulation of meiotic nuclear division
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 591 aa Download sequence Send to blast
MGVHVHVCAS LKLVLHNQVE NPIIDHTTSG ITDDYPSQRQ VIGVNTYDGV PLNPNPSHCK 60 SERDCQPFLI QTFSTNPNSE LPSSFLYKFQ FVVLGKVERQ TLSSFHHFCC CKTRPTVTGS 120 QNFPQNRNSV SSKSLTRYTI KVDEAAVILE ITFAIVDLDL PIRCLSWLGI LFLNFPFLAT 180 CSHVFCLVPN SHDMFFSKPS WLVDSNRIAT KIKSASGTNN PRSVEWKSNP SKSCPNCQHT 240 IDNSDVVQEW PGLPRGVKFD PSDQEIIWHL LAKVGIGGSR PHPFIDEFIP TVFEDDGICY 300 THPQKLPGVK QDGSVSHFFH RAIKAYNTGT RKRRKITDDD FGDVRWHKTG RTKPVVIDGV 360 QKGCKKIMVL YMSFAKGGRA EKTNWVMHQY HLGTEEDERD GEYVISKIFH QQQNVKQGEV 420 IEQEAPEIID TIKVDPHTPK SATPEPPRVE IRCVNIDPEQ DSPDGYSDEV IDDNDNHIEE 480 EPKWWEGESQ NILDSQQLVE ALSLCDDLLQ SQSPPRDGNF NHGASGSKSC FSEYAKLGPE 540 DLKKDLEECQ NLVLDPANIE LDTPPEFRLS QLDFGSQESF LAWGGKTDIE *

Sequence ? help Back to Top

Protein Sequence Length: 591 aa Download sequence Send to blast

MGVHVHVCAS LKLVLHNQVE NPIIDHTTSG ITDDYPSQRQ VIGVNTYDGV PLNPNPSHCK  60
SERDCQPFLI QTFSTNPNSE LPSSFLYKFQ FVVLGKVERQ TLSSFHHFCC CKTRPTVTGS  120
QNFPQNRNSV SSKSLTRYTI KVDEAAVILE ITFAIVDLDL PIRCLSWLGI LFLNFPFLAT  180
CSHVFCLVPN SHDMFFSKPS WLVDSNRIAT KIKSASGTNN PRSVEWKSNP SKSCPNCQHT  240
IDNSDVVQEW PGLPRGVKFD PSDQEIIWHL LAKVGIGGSR PHPFIDEFIP TVFEDDGICY  300
THPQKLPGVK QDGSVSHFFH RAIKAYNTGT RKRRKITDDD FGDVRWHKTG RTKPVVIDGV  360
QKGCKKIMVL YMSFAKGGRA EKTNWVMHQY HLGTEEDERD GEYVISKIFH QQQNVKQGEV  420
IEQEAPEIID TIKVDPHTPK SATPEPPRVE IRCVNIDPEQ DSPDGYSDEV IDDNDNHIEE  480
EPKWWEGESQ NILDSQQLVE ALSLCDDLLQ SQSPPRDGNF NHGASGSKSC FSEYAKLGPE  540
DLKKDLEECQ NLVLDPANIE LDTPPEFRLS QLDFGSQESF LAWGGKTDIE *

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269\|PubMed:19549833, ECO:0000269\|PubMed:20634150, ECO:0000269\|PubMed:24399300, ECO:0000305\|PubMed:24736489}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269\|PubMed:23907539}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	KT215862	0.0	KT215862.1 Momordica charantia cultivar 24-K NAC domain-containing protein mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011655759.1	0.0	PREDICTED: NAC domain-containing protein 8
Swissprot	Q6NQK2	1e-179	NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBL	A0A0A0KUF3	0.0	A0A0A0KUF3_CUCSA; Uncharacterized protein
STRING	XP_004159303.1	0.0	(Cucumis sativus)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF5662	33	54

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G25580.1	1e-172	NAC family protein

Link Out ? help Back to Top
Phytozome	Cucsa.283900.1

Publications ? help Back to Top
Yi D, et al. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. Plant Cell, 2014. 26(1): p. 296-309 [PMID:24399300] Biever JJ,Brinkman D,Gardner G UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation. J. Exp. Bot., 2014. 65(11): p. 2949-61 [PMID:24591052] Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell, 2015. 27(1): p. 149-61 [PMID:25595823] Chen P,Umeda M DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana. Genes Cells, 2015. 20(8): p. 636-46 [PMID:26033196] Sjogren CA,Bolaris SC,Larsen PB Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response. Plant Cell, 2015. 27(9): p. 2501-15 [PMID:26320227] Yoshiyama KO SOG1: a master regulator of the DNA damage response in plants. Genes Genet. Syst., 2016. 90(4): p. 209-16 [PMID:26617076] Weimer AK, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J., 2016. 35(19): p. 2068-2086 [PMID:27497297] Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana. Genes Cells, 2016. 21(11): p. 1195-1208 [PMID:27658920] Pedroza-García JA, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol., 2017. 173(3): p. 1735-1749 [PMID:28153919] Horvath BM, et al. Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control. EMBO J., 2017. 36(9): p. 1261-1278 [PMID:28320736] Sjogren CA,Larsen PB SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Plant Cell Environ., 2017. 40(9): p. 1849-1860 [PMID:28556304] Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana. Plant Cell, 2017. 29(12): p. 3255-3268 [PMID:29208704] Johnson RA, et al. SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration. Plant Physiol., 2018. 176(2): p. 1665-1675 [PMID:29222192] Ogita N, et al. Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Plant J., 2018. 94(3): p. 439-453 [PMID:29430765] Cao X, et al. Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots. Chemosphere, 2018. 201: p. 586-594 [PMID:29533809]