PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cucsa.192220.1
Common NameCsa_3G652380, LOC101205762
Organism
Cucumis sativus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family AP2
Protein Properties Length: 519aa    MW: 57347 Da    PI: 6.1664
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cucsa.192220.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP248.12.8e-15193252155
             AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng..kr.krfslgkfgtaeeAakaaiaarkkleg 55 
                     s+y+GV++++++gr++A+++d  +   g  ++ ++++lg ++ +e+Aa+a++ a++k++g
  Cucsa.192220.1 193 SQYRGVTRHRWTGRYEAHLWDnSCRkEGqtRKgRQVYLGGYDKEEKAARAYDLAALKYWG 252
                     78*******************655454478446*************************98 PP
2AP246.68.3e-15297346355
             AP2   3 ykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                     y+GV+++++ grW A+I  +     +k  +lg+f t eeAa+a++ a+ k++g
  Cucsa.192220.1 297 YRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFSTQEEAAEAYDIAAIKFRG 346
                     9***************988532...5************************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1014471.1E-5413No hitNo description
PfamPF008478.6E-12193252IPR001471AP2/ERF domain
CDDcd000181.07E-21193262No hitNo description
SuperFamilySSF541714.97E-17193262IPR016177DNA-binding domain
SMARTSM003806.7E-30194266IPR001471AP2/ERF domain
PROSITE profilePS5103219.111194260IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.104.7E-16194261IPR001471AP2/ERF domain
PRINTSPR003671.1E-6195206IPR001471AP2/ERF domain
SuperFamilySSF541718.5E-18295356IPR016177DNA-binding domain
CDDcd000181.58E-24295356No hitNo description
SMARTSM003802.1E-34296360IPR001471AP2/ERF domain
PROSITE profilePS5103219.137296354IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.101.5E-18296354IPR001471AP2/ERF domain
PfamPF008471.6E-9297346IPR001471AP2/ERF domain
PRINTSPR003671.1E-6336356IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 519 aa     Download sequence    Send to blast
MIPPPPPPPP PPPPPADEQP NTAAFPHLMP LRSDGTLCIS APHDWRSYEN EEESPKLEDF  60
LGNCYSNSLG NDQSHSNNAA GFIQPNNNSN NNEDDDNYNY QADQSLTPNN TNAIDKSWLG  120
PTSQNGCGSF QSLSLGMSPA NSQSDIASFT SPPSPSPPHM AADSRKRPMA VAKAFIKEPV  180
PRKSIDTFGQ RTSQYRGVTR HRWTGRYEAH LWDNSCRKEG QTRKGRQVYL GGYDKEEKAA  240
RAYDLAALKY WGSTTHINFP LSTYESELDE MKNMTRQEFV ANLRRKSSGF SRGASMYRGV  300
TRHHQHGRWQ ARIGRVAGNK DLYLGTFSTQ EEAAEAYDIA AIKFRGTSAV TNFDISRYDV  360
KRICSSSTLI AGDLAKRSPL KDGTPSTTED YTTCASPSSS SQPLLAITDG SAESHHELAN  420
MVWCDNAVAD DVNQHHENVA KMDNDLSLMG SSNRTIDPST KCSPVQNNEE FGIGVGGGEY  480
SQGYFSMQEE KYEEGDQNRQ MSVTLGHHHA PMFALWNQ*
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that recognizes and binds to the DNA consensus sequence 5'-CAC[AG]N[AT]TNCCNANG-3'. Required for the initiation and growth of ovules integumenta, and for the development of female gametophyte. Plays a critical role in the development of gynoecium marginal tissues (e.g. stigma, style and septa), and in the fusion of carpels and of medial ridges leading to ovule primordia. Also involved in organs initiation and development, including floral organs. Maintains the meristematic competence of cells and consequently sustains expression of cell cycle regulators during organogenesis, thus controlling the final size of each organ by controlling their cell number. Regulates INO autoinduction and expression pattern. As ANT promotes petal cell identity and mediates down-regulation of AG in flower whorl 2, it functions as a class A homeotic gene. {ECO:0000269|PubMed:10528263, ECO:0000269|PubMed:10639184, ECO:0000269|PubMed:10948255, ECO:0000269|PubMed:11041883, ECO:0000269|PubMed:12183381, ECO:0000269|PubMed:12271029, ECO:0000269|PubMed:12655002, ECO:0000269|PubMed:8742706, ECO:0000269|PubMed:8742707, ECO:0000269|PubMed:9001406, ECO:0000269|PubMed:9093862, ECO:0000269|PubMed:9118807}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818280.0LN681828.1 Cucumis melo genomic scaffold, anchoredscaffold00083.
GenBankLN7132580.0LN713258.1 Cucumis melo genomic chromosome, chr_4.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011651739.10.0PREDICTED: AP2-like ethylene-responsive transcription factor AIL1
SwissprotQ389141e-132ANT_ARATH; AP2-like ethylene-responsive transcription factor ANT
TrEMBLA0A0A0L9B40.0A0A0A0L9B4_CUCSA; Uncharacterized protein
STRINGXP_004148589.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF102743137
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G72570.11e-128AP2 family protein
Publications ? help Back to Top
  1. Ren Y, et al.
    An integrated genetic and cytogenetic map of the cucumber genome.
    PLoS ONE, 2009. 4(6): p. e5795
    [PMID:19495411]
  2. Guo S, et al.
    Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types.
    BMC Genomics, 2010. 11: p. 384
    [PMID:20565788]
  3. Li Z, et al.
    RNA-Seq improves annotation of protein-coding genes in the cucumber genome.
    BMC Genomics, 2011. 12: p. 540
    [PMID:22047402]
  4. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  5. Horstman A,Willemsen V,Boutilier K,Heidstra R
    AINTEGUMENTA-LIKE proteins: hubs in a plethora of networks.
    Trends Plant Sci., 2014. 19(3): p. 146-57
    [PMID:24280109]
  6. Li C, et al.
    Ectopic expression of a maize hybrid down-regulated gene ZmARF25 decreases organ size by affecting cellular proliferation in Arabidopsis.
    PLoS ONE, 2014. 9(4): p. e94830
    [PMID:24756087]
  7. Wynn AN,Seaman AA,Jones AL,Franks RG
    Novel functional roles for PERIANTHIA and SEUSS during floral organ identity specification, floral meristem termination, and gynoecial development.
    Front Plant Sci, 2014. 5: p. 130
    [PMID:24778638]
  8. Randall RS, et al.
    AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
    Biol Open, 2015. 4(10): p. 1229-36
    [PMID:26340943]
  9. Meng LS,Wang ZB,Yao SQ,Liu A
    The ARF2-ANT-COR15A gene cascade regulates ABA-signaling-mediated resistance of large seeds to drought in Arabidopsis.
    J. Cell. Sci., 2015. 128(21): p. 3922-32
    [PMID:26395398]
  10. Yamaguchi N,Jeong CW,Nole-Wilson S,Krizek BA,Wagner D
    AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
    Plant Physiol., 2016. 170(1): p. 283-93
    [PMID:26537561]
  11. Krizek BA, et al.
    RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways.
    Plant Physiol., 2016. 171(3): p. 2069-84
    [PMID:27208279]
  12. Han H,Krizek BA
    AINTEGUMENTA-LIKE6 can functionally replace AINTEGUMENTA but alters Arabidopsis flower development when misexpressed at high levels.
    Plant Mol. Biol., 2016. 92(4-5): p. 597-612
    [PMID:27605095]
  13. Karpinska B,Alomrani SO,Foyer CH
    Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling.
    Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2018.
    [PMID:28808105]
  14. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]