PlantRegMap/PlantTFDB v5.0
Plant Transcription
Factor Database
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Transcription Factor Information
Basic Information? help Back to Top | |||||||||
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TF ID | Cucsa.185850.2 | ||||||||
Organism | |||||||||
Taxonomic ID | |||||||||
Taxonomic Lineage |
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
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Family | E2F/DP | ||||||||
Protein Properties | Length: 424aa MW: 47205.9 Da PI: 4.7179 | ||||||||
Description | E2F/DP family protein | ||||||||
Gene Model |
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Signature Domain? help Back to Top | |||||||
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No. | Domain | Score | E-value | Start | End | HMM Start | HMM End |
1 | E2F_TDP | 87.2 | 1.2e-27 | 140 | 205 | 1 | 71 |
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Cucsa.185850.2 140 RYDSSLGLLTKKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 205 6899******************************...99..****************************98 PP |
Protein Features ? help Back to Top | ||||||
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Database | Entry ID | E-value | Start | End | InterPro ID | Description |
Gene3D | G3DSA:1.10.10.10 | 2.3E-29 | 138 | 207 | IPR011991 | Winged helix-turn-helix DNA-binding domain |
SMART | SM01372 | 8.0E-35 | 140 | 205 | IPR003316 | E2F/DP family, winged-helix DNA-binding domain |
SuperFamily | SSF46785 | 3.4E-17 | 140 | 203 | IPR011991 | Winged helix-turn-helix DNA-binding domain |
Pfam | PF02319 | 8.9E-25 | 142 | 205 | IPR003316 | E2F/DP family, winged-helix DNA-binding domain |
CDD | cd14660 | 6.19E-48 | 216 | 322 | No hit | No description |
SuperFamily | SSF144074 | 2.14E-34 | 217 | 322 | No hit | No description |
Pfam | PF16421 | 7.3E-34 | 221 | 320 | IPR032198 | E2F transcription factor, CC-MB domain |
Gene Ontology ? help Back to Top | ||||||
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GO Term | GO Category | GO Description | ||||
GO:0008284 | Biological Process | positive regulation of cell proliferation | ||||
GO:0009733 | Biological Process | response to auxin | ||||
GO:0010090 | Biological Process | trichome morphogenesis | ||||
GO:0045893 | Biological Process | positive regulation of transcription, DNA-templated | ||||
GO:0051302 | Biological Process | regulation of cell division | ||||
GO:0051446 | Biological Process | positive regulation of meiotic cell cycle | ||||
GO:0005634 | Cellular Component | nucleus | ||||
GO:0005667 | Cellular Component | transcription factor complex | ||||
GO:0005737 | Cellular Component | cytoplasm | ||||
GO:0003677 | Molecular Function | DNA binding | ||||
GO:0003700 | Molecular Function | transcription factor activity, sequence-specific DNA binding |
Sequence ? help Back to Top |
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Protein Sequence Length: 424 aa Download sequence Send to blast |
MSGSRPPNSS GHLPDQIMHS LKRQLPFSSM KPPFASSGDY HRFTPDSRLA DQEPDAILVK 60 SPQLKRKSEV ADYEAESTDR AIGPRFAEVV NSPHQTPASV KGGKGSKSRL TKCSRSGPQT 120 PMSNVGSPST NNLTPAGPCR YDSSLGLLTK KFINLIKQAE DGILDLNKAA DTLEVQKRRI 180 YDITNVLEGI GLIEKKLKNR IQWKGLDVSR SGDVDDNYAD LQAEVENLTM EERGLDEQIR 240 EMQERLRDLS EDENNQRWLF VTEEDIKGLP CFQNETLIAI KAPHGTTLEV PDPDEAVDYP 300 QRRYRIVLRS TMGPIDVYLV SQFEAKFEEI NAAEVPPSLP SSSGLNEAPT TTLVTEDTRG 360 KEIETREQDV HRMCSDLNAS QDFVGGIMKI VPSVVDSDAD YWLLSDADVS ITDMWRTERI 420 LTI* |
3D Structure ? help Back to Top | ||||||
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PDB ID | Evalue | Query Start | Query End | Hit Start | Hit End | Description |
1cf7_A | 2e-27 | 135 | 206 | 2 | 74 | PROTEIN (TRANSCRIPTION FACTOR E2F-4) |
Search in ModeBase |
Functional Description ? help Back to Top | ||||||
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Source | Description | |||||
UniProt | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}. |
Regulation -- Description ? help Back to Top | ||||||
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Source | Description | |||||
UniProt | INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}. |
Regulation -- PlantRegMap ? help Back to Top | ||||||
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Source | Upstream Regulator | Target Gene | ||||
PlantRegMap | Retrieve | - |
Annotation -- Nucleotide ? help Back to Top | ||||||
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Source | Hit ID | E-value | Description | |||
GenBank | LN681842 | 1e-109 | LN681842.1 Cucumis melo genomic scaffold, anchoredscaffold00022. | |||
GenBank | LN713259 | 1e-109 | LN713259.1 Cucumis melo genomic chromosome, chr_5. |
Annotation -- Protein ? help Back to Top | |||||||
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Source | Hit ID | E-value | Description | ||||
Refseq | XP_004140164.1 | 0.0 | PREDICTED: LOW QUALITY PROTEIN: transcription factor E2FB | ||||
Swissprot | Q9FV71 | 1e-150 | E2FB_ARATH; Transcription factor E2FB | ||||
TrEMBL | A0A1S3BLR6 | 0.0 | A0A1S3BLR6_CUCME; transcription factor E2FB isoform X2 | ||||
STRING | XP_004140164.1 | 0.0 | (Cucumis sativus) |
Best hit in Arabidopsis thaliana ? help Back to Top | ||||||
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Hit ID | E-value | Description | ||||
AT2G36010.1 | 1e-153 | E2F transcription factor 3 |
Link Out ? help Back to Top | |
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Phytozome | Cucsa.185850.2 |
Publications ? help Back to Top | |||
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