PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID e_gw1.7.147.1
Common NameCOCSUDRAFT_15464
Organism
Coccomyxa subellipsoidea C-169
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Chlorophyta; Trebouxiophyceae; Trebouxiophyceae incertae sedis; Coccomyxaceae; Coccomyxa; Coccomyxa subellipsoidea
Family C3H
Protein Properties Length: 501aa    MW: 56106.4 Da    PI: 8.08
Description C3H family protein
Gene Model
Gene Model ID Type Source Coding Sequence
e_gw1.7.147.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-CCCH36.67.6e-12428453126
                    --S---SGGGGTS--TTTTT-SS-SS CS
        zf-CCCH   1 yktelCrffartGtCkyGdrCkFaHg 26 
                    ++++lC+f+ +tG+Ck+G+ CkF H+
  e_gw1.7.147.1 428 PGQPLCDFYTKTGHCKFGEACKFDHP 453
                    589**********************8 PP
2zf-CCCH30.94.5e-10470495227
                    -S---SGGGGTS--TTTTT-SS-SSS CS
        zf-CCCH   2 ktelCrffartGtCkyGdrCkFaHgp 27 
                    +++ C +f +t+tCk+G+ CkF+H++
  e_gw1.7.147.1 470 GESVCGHFEKTHTCKFGPACKFHHPE 495
                    6789********************96 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM002202.1E-3017260IPR000719Protein kinase domain
PROSITE profilePS5001127.84918260IPR000719Protein kinase domain
SuperFamilySSF561125.72E-4822268IPR011009Protein kinase-like domain
PfamPF000694.8E-2922259IPR000719Protein kinase domain
Gene3DG3DSA:3.30.200.207.7E-1224113No hitNo description
PROSITE patternPS001080112124IPR008271Serine/threonine-protein kinase, active site
Gene3DG3DSA:1.10.510.101.4E-33114284No hitNo description
PROSITE profilePS5139237.857263395IPR010513KEN domain
CDDcd104221.76E-56265393No hitNo description
PfamPF064792.0E-41266393IPR010513KEN domain
SMARTSM005806.1E-15326382IPR018997PUB domain
SMARTSM003569.8E-7427454IPR000571Zinc finger, CCCH-type
PROSITE profilePS5010315.929427455IPR000571Zinc finger, CCCH-type
PfamPF006422.6E-9429453IPR000571Zinc finger, CCCH-type
Gene3DG3DSA:4.10.1000.109.6E-5432454IPR000571Zinc finger, CCCH-type
SMARTSM003560.012468495IPR000571Zinc finger, CCCH-type
PROSITE profilePS5010312.981468496IPR000571Zinc finger, CCCH-type
PfamPF006426.8E-8470495IPR000571Zinc finger, CCCH-type
SuperFamilySSF902296.15E-5471495IPR000571Zinc finger, CCCH-type
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000394Biological ProcessRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397Biological ProcessmRNA processing
GO:0006468Biological Processprotein phosphorylation
GO:0009751Biological Processresponse to salicylic acid
GO:0009816Biological Processdefense response to bacterium, incompatible interaction
GO:0030968Biological Processendoplasmic reticulum unfolded protein response
GO:0034263Biological Processautophagy in response to ER overload
GO:0090501Biological ProcessRNA phosphodiester bond hydrolysis
GO:0005783Cellular Componentendoplasmic reticulum
GO:0004521Molecular Functionendoribonuclease activity
GO:0004672Molecular Functionprotein kinase activity
GO:0005524Molecular FunctionATP binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 501 aa     Download sequence    Send to blast
MQSREVARAG VSRVGRMEIG PEILGYGSSG TLVFEGTLHG RPIAVKRILS QFYELARKEI  60
GALILSDEHP NIVRCFAMEE DNEFVYLALE RCRQSLNDLA GHGVVALHQR GIVHRDIKPQ  120
NILLTESRHA KLSDMGLCKR LAIDQSSTCR NGLISIAPIA GGSTGWQAPE QLISRSGGDV  180
RQGKSVDIFS FGLVIFYCLT GGKHAFGESY ERDFNILQAR PTSLREVAHL KEAENLVRAM  240
LVPAPKRRPS IASVMAHPFW WPPQRRLSFL VDLSDRMENE DREEDQSLLA ALEACSEEAL  300
GGRNWMARLD PDFLENLGRY RKYRPDSLRD LLRVIRNKHN HFRELPEQLQ AKLGPMPDGF  360
LSYFSSRFPN LLMATYCFGL HRCSEEPMLA KYYPAGAREF PLELIDGMNS VASSMQPPPL  420
KPSFPCRPGQ PLCDFYTKTG HCKFGEACKF DHPAHFGVQL NSLGLPLRQG ESVCGHFEKT  480
HTCKFGPACK FHHPEPLHGA *
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3fbv_B6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_C6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_D6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_E6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_F6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_G6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_H6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_I6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_J6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_K6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_L6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_M6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_N6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_A6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_B6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_C6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_D6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_E6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_F6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_G6e-961939236445Serine/threonine-protein kinase/endoribonuclease IRE1
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtSenses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices bZIP60 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator which then induces transcription of UPR target genes. Involved in organ growth regulation. Plays a role in plant immunity and abiotic stress responses. Required for ER stress-induced autophagy. {ECO:0000269|PubMed:11706177, ECO:0000269|PubMed:21482766, ECO:0000269|PubMed:21914012, ECO:0000269|PubMed:22355548, ECO:0000269|PubMed:22359644, ECO:0000269|PubMed:22701744, ECO:0000269|PubMed:23175745}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By ER stress inducer tunicamycin, by salicylic acid (SA) and by bacterial pathogen infection. {ECO:0000269|PubMed:22359644}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_005648143.10.0hypothetical protein COCSUDRAFT_15464
SwissprotQ93VJ21e-105IRE1B_ARATH; Serine/threonine-protein kinase/endoribonuclease IRE1b
TrEMBLI0YYY00.0I0YYY0_COCSC; Uncharacterized protein
STRINGXP_005648143.10.0(Coccomyxa subellipsoidea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
ChlorophytaeOGCP28241112
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G16540.35e-20zinc finger nuclease 3
Publications ? help Back to Top
  1. Koizumi N, et al.
    Molecular characterization of two Arabidopsis Ire1 homologs, endoplasmic reticulum-located transmembrane protein kinases.
    Plant Physiol., 2001. 127(3): p. 949-62
    [PMID:11706177]
  2. Noh SJ,Kwon CS,Chung WI
    Characterization of two homologs of Ire1p, a kinase/endoribonuclease in yeast, in Arabidopsis thaliana.
    Biochim. Biophys. Acta, 2002. 1575(1-3): p. 130-4
    [PMID:12020828]
  3. Chen Y,Brandizzi F
    AtIRE1A/AtIRE1B and AGB1 independently control two essential unfolded protein response pathways in Arabidopsis.
    Plant J., 2012. 69(2): p. 266-77
    [PMID:21914012]
  4. Blanc G, et al.
    The genome of the polar eukaryotic microalga Coccomyxa subellipsoidea reveals traits of cold adaptation.
    Genome Biol., 2012. 13(5): p. R39
    [PMID:22630137]
  5. Chen Y, et al.
    Inter-regulation of the unfolded protein response and auxin signaling.
    Plant J., 2014. 77(1): p. 97-107
    [PMID:24180465]
  6. Gaguancela OA, et al.
    The IRE1/bZIP60 Pathway and Bax Inhibitor 1 Suppress Systemic Accumulation of Potyviruses and Potexviruses in Arabidopsis and Nicotiana benthamiana Plants.
    Mol. Plant Microbe Interact., 2016. 29(10): p. 750-766
    [PMID:27578623]