PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PK24181.1
Organism
Cannabis sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Cannabis
Family HD-ZIP
Protein Properties Length: 734aa    MW: 79965.6 Da    PI: 6.7758
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PK24181.1genomeCCBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox63.53e-202580156
               TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
   Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
               +++ +++t++q++ Le++F+++++p++++r +L+++lgL  rq+k+WFqNrR+++k
  PK24181.1 25 KKRYHRHTAHQIQKLESMFKECPHPDEKQRLQLSRELGLAPRQIKFWFQNRRTQMK 80
               678899***********************************************998 PP
2START184.36.7e-582344592206
                HHHHHHHHHHHHHHHC-TT-EEEE.....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEEEEEEC CS
      START   2 laeeaaqelvkkalaeepgWvkss.....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetla....kaetlevis 86 
                +a  a++el+++ + +ep+W++ s     + +n d + ++f+++++       ++ea++++gvv+m+   lv  ++d + +W e ++     a tlevis
  PK24181.1 234 IATNAMEELLRLLQPNEPFWMRPSsgdgrDVLNLDNYDRNFPRANThmknpnLRIEASKDTGVVIMNGLALVDMFMDPN-KWAELFPnivsMARTLEVIS 332
                56789*****************999999999************999*********************************.******9999999******* PP

                TT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--SSXX.H CS
      START  87 sg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwvehvdlkgrlp.h 178
                sg      ++lqlm+aelq+lsplvp R+f+f+Ry+ q ++g w++vdvS d +++++   +  R+++lpSg+li++++ng+skvtwveh++ ++++p h
  PK24181.1 333 SGglgshsSTLQLMYAELQVLSPLVPtREFYFLRYCHQIEQGLWAVVDVSYDFPRDNQ-FVNQCRCHRLPSGCLIQDMPNGYSKVTWVEHIEIEDKVPtH 431
                *********************************************************9.799************************************** PP

                HHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
      START 179 wllrslvksglaegaktwvatlqrqcek 206
                 l+r lv+sg+a+ga +w+ tlqr ce+
  PK24181.1 432 RLYRDLVHSGMAFGAERWLTTLQRMCER 459
                **************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466891.3E-20882IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.601.3E-221076IPR009057Homeodomain-like
PROSITE profilePS5007118.0742282IPR001356Homeobox domain
SMARTSM003892.3E-192386IPR001356Homeobox domain
CDDcd000861.28E-182483No hitNo description
PfamPF000467.7E-182580IPR001356Homeobox domain
PROSITE patternPS0002705780IPR017970Homeobox, conserved site
PROSITE profilePS5084852.684224462IPR002913START domain
SuperFamilySSF559612.0E-41225461No hitNo description
CDDcd088755.45E-114228458No hitNo description
SMARTSM002342.2E-48233459IPR002913START domain
PfamPF018521.2E-49234459IPR002913START domain
Gene3DG3DSA:3.30.530.209.6E-8294458IPR023393START-like domain
SuperFamilySSF559614.23E-24480660No hitNo description
SuperFamilySSF559614.23E-24687726No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 734 aa     Download sequence    Send to blast
MEYASGGGGG SGGGDNDASN AQRRKKRYHR HTAHQIQKLE SMFKECPHPD EKQRLQLSRE  60
LGLAPRQIKF WFQNRRTQMK AQHERADNCA LRAENDKIRC ENIAIREALK NVICPSCGGP  120
PPIEDPYFDD QKLRMENAQL KEELDRVSSI AAKYIGRPIS QLPPVQPIHI SSLDLSMASF  180
PQGMGIGLGC GGGGGGGCTS LDLDLLPGSS STMPTMPYQP PGISDMDKSL MSDIATNAME  240
ELLRLLQPNE PFWMRPSSGD GRDVLNLDNY DRNFPRANTH MKNPNLRIEA SKDTGVVIMN  300
GLALVDMFMD PNKWAELFPN IVSMARTLEV ISSGGLGSHS STLQLMYAEL QVLSPLVPTR  360
EFYFLRYCHQ IEQGLWAVVD VSYDFPRDNQ FVNQCRCHRL PSGCLIQDMP NGYSKVTWVE  420
HIEIEDKVPT HRLYRDLVHS GMAFGAERWL TTLQRMCERY ACLMVSGTST RELGGVIPSP  480
DGKRSLMKLA QRMVNHFCAS VSSSTSNGQR WTTLSGTGIN EVGVRVTVHK STDPGQPNGV  540
VLSAATTIWL PVSPQDVFNF FKDERTRAQW DVLSNGNAVQ EVAHIANGSH HGNCISVLRA  600
FNTSQNNMLI LQESCVDSSG SMVVYCPVDL PAINIAMSGE DPSYIPLLPS GFTISPDGRA  660
SQGGGGGGGG GDGASTSAGA GSSQSGGSLI TVAFQILVSS LPSAKLNMES VNTVNNLIGN  720
TVQQIKTALN CPTS
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010099679.10.0homeobox-leucine zipper protein HDG11
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A2P5B2950.0A0A2P5B295_TREOI; Octamer-binding transcription factor
STRINGXP_010099679.10.0(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF10263398
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]