PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PK15717.1
Organism
Cannabis sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Cannabis
Family MIKC_MADS
Protein Properties Length: 302aa    MW: 34279.1 Da    PI: 9.4198
Description MIKC_MADS family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PK15717.1genomeCCBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1SRF-TF98.82.1e-314493150
               S---SHHHHHHHHHHHHHHHHHHHHHHHHHHT-EEEEEEE-TTSEEEEEE CS
     SRF-TF  1 krienksnrqvtfskRrngilKKAeELSvLCdaevaviifsstgklyeys 50
               krien++nrqvtf+kRrng+lKKA+ELSvLCdaeva+i+fss+g+lyey+
  PK15717.1 44 KRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALIVFSSRGRLYEYA 93
               79***********************************************8 PP
2K-box106.33.6e-351112083100
      K-box   3 kssgksleeakaeslqqelakLkkeienLqreqRhllGedLesLslkeLqqLeqqLekslkkiRskKnellleqieelqkkekelqeenkaLrkklee 100
                +s++ s++e +a+ +qqe+akL+ +ie+Lq+ +R llGe+++s + ++L++Le++Le+++++iRskKnell+++ie++qk+e +l+++n+ Lr+k++e
  PK15717.1 111 TSNTGSVSEVNAQFYQQEAAKLRGQIESLQKGIRELLGECIDSAKPRDLKNLESKLERGISRIRSKKNELLFAEIEYMQKREIDLHNNNQLLRAKIAE 208
                4444559****************************************************************************************986 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5006634.1043696IPR002100Transcription factor, MADS-box
SMARTSM004321.5E-423695IPR002100Transcription factor, MADS-box
CDDcd002651.60E-4437110No hitNo description
SuperFamilySSF554553.14E-3337109IPR002100Transcription factor, MADS-box
PRINTSPR004047.4E-333858IPR002100Transcription factor, MADS-box
PROSITE patternPS0035003892IPR002100Transcription factor, MADS-box
PfamPF003191.3E-264592IPR002100Transcription factor, MADS-box
PRINTSPR004047.4E-335873IPR002100Transcription factor, MADS-box
PRINTSPR004047.4E-337394IPR002100Transcription factor, MADS-box
PfamPF014861.0E-25121206IPR002487Transcription factor, K-box
PROSITE profilePS5129714.572122212IPR002487Transcription factor, K-box
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0048366Biological Processleaf development
GO:0048440Biological Processcarpel development
GO:0048443Biological Processstamen development
GO:0048497Biological Processmaintenance of floral organ identity
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 302 aa     Download sequence    Send to blast
SSSEMAYNNN NNSNNNVNNS ISMSMSMSVS SPGRKMGRGK IEIKRIENTT NRQVTFCKRR  60
NGLLKKAYEL SVLCDAEVAL IVFSSRGRLY EYANQSVKST IDRYKKASSD TSNTGSVSEV  120
NAQFYQQEAA KLRGQIESLQ KGIRELLGEC IDSAKPRDLK NLESKLERGI SRIRSKKNEL  180
LFAEIEYMQK REIDLHNNNQ LLRAKIAENE RNQSMSMNMN MNINMNMNVG TSSYGHHHEL  240
IHQNHNNNND NNNNNNNNNN DDEGAASVVV HQQPGNYFQV NALQPNNNHY SRQDPTMALQ  300
LV
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1tqe_P4e-2136108173Myocyte-specific enhancer factor 2B
1tqe_Q4e-2136108173Myocyte-specific enhancer factor 2B
1tqe_R4e-2136108173Myocyte-specific enhancer factor 2B
1tqe_S4e-2136108173Myocyte-specific enhancer factor 2B
5f28_A5e-2136104169MEF2C
5f28_B5e-2136104169MEF2C
5f28_C5e-2136104169MEF2C
5f28_D5e-2136104169MEF2C
6c9l_A4e-2136108173Myocyte-specific enhancer factor 2B
6c9l_B4e-2136108173Myocyte-specific enhancer factor 2B
6c9l_C4e-2136108173Myocyte-specific enhancer factor 2B
6c9l_D4e-2136108173Myocyte-specific enhancer factor 2B
6c9l_E4e-2136108173Myocyte-specific enhancer factor 2B
6c9l_F4e-2136108173Myocyte-specific enhancer factor 2B
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor involved in the control of organ identity during the early development of flowers. Is required for normal development of stamens and carpels in the wild-type flower. Plays a role in maintaining the determinacy of the floral meristem. Acts as C class cadastral protein by repressing the A class floral homeotic genes like APETALA1. Forms a heterodimer via the K-box domain with either SEPALATTA1/AGL2, SEPALATTA2/AGL4, SEPALLATA3/AGL9 or AGL6 that could be involved in genes regulation during floral meristem development. Controls AHL21/GIK, a multifunctional chromatin modifier in reproductive organ patterning and differentiation (PubMed:19956801). Induces microsporogenesis through the activation of SPL/NZZ (PubMed:15254538). {ECO:0000269|PubMed:15254538, ECO:0000269|PubMed:19956801}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00609ChIP-seqTransfer from AT4G18960Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Negatively regulated by the A class floral homeotic protein APETALA2 and by other repressors like LEUNIG, SEUSS, SAP or CURLY LEAF. Positively regulated by both LEAFY and APETALA1. Repressed by silencing mediated by polycomb group (PcG) protein complex containing EMF1 and EMF2. Up-regulated by HUA2. {ECO:0000269|PubMed:10198637, ECO:0000269|PubMed:11058164, ECO:0000269|PubMed:1675158, ECO:0000269|PubMed:17794879, ECO:0000269|PubMed:18281509, ECO:0000269|PubMed:19783648, ECO:0000269|PubMed:9783581}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015876427.11e-121floral homeotic protein AGAMOUS isoform X3
RefseqXP_015876435.11e-121floral homeotic protein AGAMOUS isoform X4
SwissprotP178391e-110AG_ARATH; Floral homeotic protein AGAMOUS
TrEMBLA0A2P5C0X01e-129A0A2P5C0X0_PARAD; MADS-box transcription factor
STRINGXP_008225406.11e-114(Prunus mume)
STRINGEMJ131241e-115(Prunus persica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF68429102
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G18960.11e-109MIKC_MADS family protein
Publications ? help Back to Top
  1. Huang Z, et al.
    APETALA2 antagonizes the transcriptional activity of AGAMOUS in regulating floral stem cells in Arabidopsis thaliana.
    New Phytol., 2017. 215(3): p. 1197-1209
    [PMID:27604611]
  2. Rong XF, et al.
    Type-B ARRs Control Carpel Regeneration Through Mediating AGAMOUS Expression in Arabidopsis.
    Plant Cell Physiol., 2018. 59(4): p. 756-764
    [PMID:29186581]
  3. Uemura A, et al.
    Regulation of floral meristem activity through the interaction of AGAMOUS, SUPERMAN, and CLAVATA3 in Arabidopsis.
    Plant Reprod, 2018. 31(1): p. 89-105
    [PMID:29218596]