PlantRegMap/PlantTFDB v5.0
Plant Transcription
Factor Database
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Transcription Factor Information
Basic Information? help Back to Top | |||||||||
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TF ID | PK12630.1 | ||||||||
Organism | |||||||||
Taxonomic ID | |||||||||
Taxonomic Lineage |
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Cannabis
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Family | C2H2 | ||||||||
Protein Properties | Length: 1482aa MW: 165652 Da PI: 8.3787 | ||||||||
Description | C2H2 family protein | ||||||||
Gene Model |
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Signature Domain? help Back to Top | |||||||
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No. | Domain | Score | E-value | Start | End | HMM Start | HMM End |
1 | zf-C2H2 | 12.9 | 0.00033 | 1392 | 1414 | 3 | 23 |
ET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 3 Cp..dCgksFsrksnLkrHirtH 23 Cp Cgk F ++ +L++H r+H PK12630.1 1392 CPvkGCGKKFFSHKYLVQHRRVH 1414 9999*****************99 PP | |||||||
2 | zf-C2H2 | 11.8 | 0.00072 | 1450 | 1476 | 1 | 23 |
EEET..TTTEEESSHHHHHHHHHH..T CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirt..H 23 y+C Cg++F+ s++ rH r+ H PK12630.1 1450 YVCAepGCGQTFRFVSDFSRHKRKtgH 1476 899999****************99666 PP |
Protein Features ? help Back to Top | ||||||
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Database | Entry ID | E-value | Start | End | InterPro ID | Description |
SMART | SM00545 | 7.5E-18 | 23 | 64 | IPR003349 | JmjN domain |
PROSITE profile | PS51183 | 14.88 | 24 | 65 | IPR003349 | JmjN domain |
Pfam | PF02375 | 3.7E-14 | 25 | 58 | IPR003349 | JmjN domain |
SMART | SM00558 | 7.1E-50 | 196 | 365 | IPR003347 | JmjC domain |
PROSITE profile | PS51184 | 32.126 | 199 | 365 | IPR003347 | JmjC domain |
SuperFamily | SSF51197 | 2.06E-25 | 210 | 366 | No hit | No description |
Pfam | PF02373 | 5.5E-37 | 229 | 348 | IPR003347 | JmjC domain |
SMART | SM00355 | 28 | 1367 | 1389 | IPR015880 | Zinc finger, C2H2-like |
SMART | SM00355 | 0.0045 | 1390 | 1414 | IPR015880 | Zinc finger, C2H2-like |
PROSITE profile | PS50157 | 12.445 | 1390 | 1419 | IPR007087 | Zinc finger, C2H2 |
SuperFamily | SSF57667 | 9.34E-6 | 1391 | 1426 | No hit | No description |
Gene3D | G3DSA:3.30.160.60 | 1.2E-5 | 1392 | 1413 | IPR013087 | Zinc finger C2H2-type/integrase DNA-binding domain |
PROSITE pattern | PS00028 | 0 | 1392 | 1414 | IPR007087 | Zinc finger, C2H2 |
Gene3D | G3DSA:3.30.160.60 | 5.8E-9 | 1414 | 1442 | IPR013087 | Zinc finger C2H2-type/integrase DNA-binding domain |
PROSITE profile | PS50157 | 10.637 | 1420 | 1449 | IPR007087 | Zinc finger, C2H2 |
SMART | SM00355 | 0.0017 | 1420 | 1444 | IPR015880 | Zinc finger, C2H2-like |
PROSITE pattern | PS00028 | 0 | 1422 | 1444 | IPR007087 | Zinc finger, C2H2 |
SuperFamily | SSF57667 | 2.81E-9 | 1430 | 1474 | No hit | No description |
Gene3D | G3DSA:3.30.160.60 | 2.3E-9 | 1443 | 1473 | IPR013087 | Zinc finger C2H2-type/integrase DNA-binding domain |
SMART | SM00355 | 0.62 | 1450 | 1476 | IPR015880 | Zinc finger, C2H2-like |
PROSITE profile | PS50157 | 11.032 | 1450 | 1481 | IPR007087 | Zinc finger, C2H2 |
PROSITE pattern | PS00028 | 0 | 1452 | 1476 | IPR007087 | Zinc finger, C2H2 |
Gene Ontology ? help Back to Top | ||||||
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GO Term | GO Category | GO Description | ||||
GO:0009741 | Biological Process | response to brassinosteroid | ||||
GO:0009826 | Biological Process | unidimensional cell growth | ||||
GO:0010228 | Biological Process | vegetative to reproductive phase transition of meristem | ||||
GO:0033169 | Biological Process | histone H3-K9 demethylation | ||||
GO:0035067 | Biological Process | negative regulation of histone acetylation | ||||
GO:0040010 | Biological Process | positive regulation of growth rate | ||||
GO:0045815 | Biological Process | positive regulation of gene expression, epigenetic | ||||
GO:0048366 | Biological Process | leaf development | ||||
GO:0005634 | Cellular Component | nucleus | ||||
GO:0003676 | Molecular Function | nucleic acid binding | ||||
GO:0046872 | Molecular Function | metal ion binding | ||||
GO:0071558 | Molecular Function | histone demethylase activity (H3-K27 specific) |
Sequence ? help Back to Top |
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Protein Sequence Length: 1482 aa Download sequence Send to blast |
MAASTLGSDP SPEVFSWLKT LPLAPEYHPT LAEFQDPISY IFKIEKEASK YGICKIIPPV 60 SPSPKKTVIA NLNKSLAARA GYSEGSNPKT PPTFTTRQQQ IGFCPRKPRP VQRPVWQSGE 120 QYTFQEFETK AKGFEKGFLK KCGKKGGGLS PLEIETLYWK ATVDKPFSVE YANDMPGSAF 180 VPVNAKKSRE AGESVTLGET AWNMRAVSRS KGSLLRFMKE EIPGVTSPMV YVAMLFSWFA 240 WHVEDHDLHS LNYLHMGASK TWYGVPKEAA VAFEEVIRVH GYGAEINPLV TFSILGEKTT 300 VMSPEVFIKE GVPCCRLVQN AGEFVVTFPR AYHTGFSHGF NCAEAANIAT PEWLRVANDA 360 AIRRASINYP PMVSHFQLLY DLALALCSRI PLSIGSEPRS SRLKDKRKGE GETVVKELFV 420 QDVLKNNDLL HVLGKGSPIV LLPRTSSDIP LCSKLRVGSH LRSNTSLSIE EMKSSRSLIS 480 DDLMVDRKQE VDQVKEFYPV KGKLASLCEG SWVPSRGNKR TSGSNFKTPI KSVEVKNNVD 540 SDRLSEQRLF SCVTCGILSF ACVAIVQPKD PAARYLMAAD CSFFNDWVVN AGVASNVFPI 600 SNVDQTESKQ NNYTAWADNC APDSYDGPVP SISNQVQMED QNNEVLSNSE AHEATSALGL 660 LALHYGNSSD SEEDQVREDD SIYENETNME NCSPESKYRC ESSGLSFQNS LSDAAGDDGR 720 SPQELDLGEE RASQNADFHK ENGHNRDDVK YSNRQNVGCS VDASNNVAST ETNCLVGKIR 780 DPMIVSQTCS ADTYDAEATR FCKGIVPMKN EGVPLAPLSD EDSSRMHVFC LEHAVEVEQQ 840 LRQIGGVHIL LLCHPDYPKI ETEAKSIAEE LGINCALNDT TFRDATKDDQ EKIQSALDSE 900 DAMPKNGDWA VKLGINLFYS ANLSRSPLYS KQMPYNSVIY NAFGRTSPTS SSVRSDGFGR 960 RSVKKKVVAG KWCGKVWMSN QVHPLLVKRN PEDEEERGIL AWATPDENLD RNHDTPHRNS 1020 NTMVAKKYVR KRKMKVGNES IKKAKCIKGE DIVSENSMDD DSHEPHRRPF GNNQATRIGG 1080 GSTKKGKQHI QREDAVSDDS MYVSLKQCKR TLRTKVATSV ETDDIVSDDS LGVISNYRNR 1140 KNPRSEKAKH VRDAGIQDVV SDDSLDFESN QRGGRIPKSK QAKFMEEEDS ASDDLPSTNL 1200 YKQQTRIYKS KYAKSIERED DVSDEPVEDY ACDEDKRVLR SKPTKSPMQP KMKQGTGRNV 1260 RQPSSQPVKQ GTRQIMKKET QKTKLHTPRL RNSQCDQDTS HICDDEEEEG GPSTRLRKRT 1320 PKPQKTTGTK KKEQQQQTSN KKAKNVSAGK AQAGRSDTKL KDEEAEYVCD VEGCTMSFGV 1380 KHELVLHKRN ICPVKGCGKK FFSHKYLVQH RRVHMDDRPL RCPWKGCKMT FKWAWARTEH 1440 IRVHTGARPY VCAEPGCGQT FRFVSDFSRH KRKTGHSTKK GR |
3D Structure ? help Back to Top | ||||||
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PDB ID | Evalue | Query Start | Query End | Hit Start | Hit End | Description |
6ip0_A | 7e-76 | 17 | 386 | 8 | 353 | Transcription factor jumonji (Jmj) family protein |
6ip4_A | 7e-76 | 17 | 386 | 8 | 353 | Arabidopsis JMJ13 |
Search in ModeBase |
Nucleic Localization Signal ? help Back to Top | |||
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No. | Start | End | Sequence |
1 | 959 | 965 | RRSVKKK |
2 | 1026 | 1032 | KYVRKRK |
Functional Description ? help Back to Top | ||||||
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Source | Description | |||||
UniProt | Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3. Demethylates both tri- (H3K27me3) and di-methylated (H3K27me2) H3K27me (PubMed:21642989, PubMed:27111035). Demethylates also H3K4me3/2 and H3K36me3/2 in an in vitro assay (PubMed:20711170). Involved in the transcriptional regulation of hundreds of genes regulating developmental patterning and responses to various stimuli (PubMed:18467490). Binds DNA via its four zinc fingers in a sequence-specific manner, 5'-CTCTGYTY-3', to promote the demethylation of H3K27me3 and the regulation of organ boundary formation (PubMed:27111034, PubMed:27111035). Involved in the regulation of flowering time by repressing FLOWERING LOCUS C (FLC) expression (PubMed:15377760). Interacts with the NF-Y complexe to regulate SOC1 (PubMed:25105952). Mediates the recruitment of BRM to its target loci (PubMed:27111034). {ECO:0000269|PubMed:15377760, ECO:0000269|PubMed:18467490, ECO:0000269|PubMed:20711170, ECO:0000269|PubMed:21642989, ECO:0000269|PubMed:25105952, ECO:0000269|PubMed:27111034, ECO:0000269|PubMed:27111035}. |
Binding Motif ? help Back to Top | |||
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Motif ID | Method | Source | Motif file |
MP00608 | ChIP-seq | Transfer from AT3G48430 | Download |
Annotation -- Protein ? help Back to Top | |||||||
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Source | Hit ID | E-value | Description | ||||
Refseq | XP_010101942.1 | 0.0 | lysine-specific demethylase REF6 | ||||
Swissprot | Q9STM3 | 0.0 | REF6_ARATH; Lysine-specific demethylase REF6 | ||||
TrEMBL | A0A2P5EIB2 | 0.0 | A0A2P5EIB2_TREOI; TFIIH C1-like domain containing protein | ||||
STRING | XP_010101942.1 | 0.0 | (Morus notabilis) |
Orthologous Group ? help Back to Top | |||
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Lineage | Orthologous Group ID | Taxa Number | Gene Number |
Fabids | OGEF5648 | 32 | 50 |
Best hit in Arabidopsis thaliana ? help Back to Top | ||||||
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Hit ID | E-value | Description | ||||
AT3G48430.1 | 0.0 | relative of early flowering 6 |