PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID cra_locus_39137_iso_2
Organism
Catharanthus roseus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus
Family bHLH
Protein Properties Length: 408aa    MW: 45563.8 Da    PI: 6.2934
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
cra_locus_39137_iso_2genomeMPGR-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH38.12.8e-12200251155
                                           CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                                   HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                                           +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A+e++++L+
  cra_locus_39137_iso_2_len_1557_ver_3 200 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 251
                                           79****************************...9*****************9995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.101.4E-13198254IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000832.64E-13198255No hitNo description
SuperFamilySSF474592.36E-16199263IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.428199250IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.3E-9200251IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.4E-9205256IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd048730.00347334398No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 408 aa     Download sequence    Send to blast
MEKEGNNYSP SNFTSSSVLD HHHYMMMKPQ IGSGEISTSS SVAAAAAAAA FDHHRHNNNN  60
NQMMMNNLSF ADVMQFADFG PKLGLNQFVP KNSDHHHHHH QEEEDQENGI IDPVYFLKFP  120
VLNDKLQDEN DQENHHQWGS EESKEENNNG LVQLGFLGEN IAVEDDIKKK KVGGVGENNN  180
NKNKRKRARS VKTSEEVESQ RMTHIAVERN RRKQMNEHLR VLRSLMPGSY VQRGDQASII  240
GGAIEFVREL EQLLQCLESQ KRRRLYGDGG GGGSRQIAAA GDTSSSPLAI QQPPTFMPPL  300
PNELETGGGL HEETAESKSC LADIEVKVFG FDAMIKILSR RRPGQLIKTI AALEDLQLNI  360
LHTNITTIEQ TVLYSFNVKV GGEARYTAED IANSVQQIFS FIHANTTI
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1168186KKKVGGVGENNNNKNKRKR
2200211RMTHIAVERNRR
3260264KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027119013.11e-155transcription factor FAMA-like isoform X2
RefseqXP_027120772.11e-155transcription factor FAMA-like isoform X2
SwissprotQ56YJ81e-139FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A068TT281e-152A0A068TT28_COFCA; Uncharacterized protein
STRINGXP_009795997.11e-146(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA46572341
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]