PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID cra_locus_23047_iso_1
Organism
Catharanthus roseus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus
Family E2F/DP
Protein Properties Length: 349aa    MW: 39024 Da    PI: 6.9085
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
cra_locus_23047_iso_1genomeMPGR-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP83.41.8e-26102167171
                               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                                           r+++sL+llt+kfl+l+++++ g+++ln+ a+ L   +v  ++RRiYDi+NVLe+++liek+ kn+irw+g
  cra_locus_23047_iso_1_len_1142_ver_3 102 RYDSSLGLLTKKFLNLIQEAPGGTLDLNKTADVL---EV--QKRRIYDITNVLEGIGLIEKTTKNHIRWRG 167
                                           6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.8E-2899168IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.1E-35102167IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467857.71E-18102165IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023196.7E-25104167IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440748.63E-26180286No hitNo description
CDDcd146602.43E-36183285No hitNo description
PfamPF164211.7E-24183283IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000902Biological Processcell morphogenesis
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0042023Biological ProcessDNA endoreduplication
GO:0051782Biological Processnegative regulation of cell division
GO:0005667Cellular Componenttranscription factor complex
GO:0005730Cellular Componentnucleolus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
GO:0046982Molecular Functionprotein heterodimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 349 aa     Download sequence    Send to blast
MSNTHEINLN LTLGTLNTSF SNVSLESQQS RCSVPQLLAS CSSRRSPFLP SASSTTAAFP  60
DSKHALATAS PPKARGSKLA KSGTVEANAE ILENLGLSGS CRYDSSLGLL TKKFLNLIQE  120
APGGTLDLNK TADVLEVQKR RIYDITNVLE GIGLIEKTTK NHIRWRGSEL LGPRELDHQA  180
NFLKAEVEHL YAEECRLDNR IREKLEQLRA LEFDQTSQRN LFLTKEDIMN LPCFRDKTVI  240
AVKAPHASNI EVPDPEEEMD LSGKKHYRLI LRSNTGPIDL YLLSKNQKKH EDLAAKRRKS  300
SDLWVSSVSR HRIDNAEASG IHKIIPLDDA DGDDYWLRSD HEATATDLW
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-22102173776PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00190DAPTransfer from AT1G47870Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027092083.11e-122transcription factor E2FC-like
RefseqXP_027094734.11e-122transcription factor E2FC-like
SwissprotQ9FV704e-87E2FC_ARATH; Transcription factor E2FC
TrEMBLA0A2G9HCT71e-113A0A2G9HCT7_9LAMI; Uncharacterized protein
STRINGMigut.C00805.1.p1e-114(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA126252022
Publications ? help Back to Top
  1. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  2. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  3. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]